Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor
Essential tremor (ET) is a common movement disorder characterized by kinetic and postural tremor in the upper extremities and frequently in the midline. Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in pers...
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| Veröffentlicht in: | Tremor and other hyperkinetic movements (New York, N.Y.) N.Y.), 2019, Vol.9 |
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| container_title | Tremor and other hyperkinetic movements (New York, N.Y.) |
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| creator | Higuchi, Masa-Aki Roemmich, Ryan T Martinez-Ramirez, Daniel Roper, Jaimie A Zukowski, Lisa A Foote, Kelly D Okun, Michael S Hass, Chris J |
| description | Essential tremor (ET) is a common movement disorder characterized by kinetic and postural tremor in the upper extremities and frequently in the midline. Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in persons with ET, suggesting a common pathophysiology distinct from that of upper extremity tremor. However, a causal link between midline tremor and gait impairment has not been established.
We investigated tremor and gait in 24 persons with ET before and after implantation of unilateral deep brain stimulation into the ventralis intermedius nucleus of the thalamus.
Stimulation significantly improved tremor in the targeted upper extremity and midline. However, gait was unaffected at the cohort level. Furthermore, improvement in midline tremor was not significantly associated with gait improvement.
These findings revealed that midline tremor and gait impairment may be dissociable in persons with ET. |
| doi_str_mv | 10.5334/tohm.469 |
| format | Article |
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We investigated tremor and gait in 24 persons with ET before and after implantation of unilateral deep brain stimulation into the ventralis intermedius nucleus of the thalamus.
Stimulation significantly improved tremor in the targeted upper extremity and midline. However, gait was unaffected at the cohort level. Furthermore, improvement in midline tremor was not significantly associated with gait improvement.
These findings revealed that midline tremor and gait impairment may be dissociable in persons with ET.</description><identifier>ISSN: 2160-8288</identifier><identifier>EISSN: 2160-8288</identifier><identifier>DOI: 10.5334/tohm.469</identifier><identifier>PMID: 31565538</identifier><language>eng</language><publisher>United States: Ubiquity Press</publisher><subject>Aged ; Ataxia ; Cohort Studies ; Deep Brain Stimulation ; Essential Tremor - complications ; Essential Tremor - therapy ; Female ; Gait ; Gait Disorders, Neurologic - etiology ; Gait Disorders, Neurologic - therapy ; Humans ; Hypotheses ; Male ; Middle Aged ; Movement disorders ; Pathophysiology ; Surgery ; Treatment Outcome ; Tremor (Muscular contraction) ; Ventral Thalamic Nuclei - surgery</subject><ispartof>Tremor and other hyperkinetic movements (New York, N.Y.), 2019, Vol.9</ispartof><rights>2019 Higuchi et al.</rights><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31565538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higuchi, Masa-Aki</creatorcontrib><creatorcontrib>Roemmich, Ryan T</creatorcontrib><creatorcontrib>Martinez-Ramirez, Daniel</creatorcontrib><creatorcontrib>Roper, Jaimie A</creatorcontrib><creatorcontrib>Zukowski, Lisa A</creatorcontrib><creatorcontrib>Foote, Kelly D</creatorcontrib><creatorcontrib>Okun, Michael S</creatorcontrib><creatorcontrib>Hass, Chris J</creatorcontrib><title>Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor</title><title>Tremor and other hyperkinetic movements (New York, N.Y.)</title><addtitle>Tremor Other Hyperkinet Mov (N Y)</addtitle><description>Essential tremor (ET) is a common movement disorder characterized by kinetic and postural tremor in the upper extremities and frequently in the midline. Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in persons with ET, suggesting a common pathophysiology distinct from that of upper extremity tremor. However, a causal link between midline tremor and gait impairment has not been established.
We investigated tremor and gait in 24 persons with ET before and after implantation of unilateral deep brain stimulation into the ventralis intermedius nucleus of the thalamus.
Stimulation significantly improved tremor in the targeted upper extremity and midline. However, gait was unaffected at the cohort level. Furthermore, improvement in midline tremor was not significantly associated with gait improvement.
These findings revealed that midline tremor and gait impairment may be dissociable in persons with ET.</description><subject>Aged</subject><subject>Ataxia</subject><subject>Cohort Studies</subject><subject>Deep Brain Stimulation</subject><subject>Essential Tremor - complications</subject><subject>Essential Tremor - therapy</subject><subject>Female</subject><subject>Gait</subject><subject>Gait Disorders, Neurologic - etiology</subject><subject>Gait Disorders, Neurologic - therapy</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Pathophysiology</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tremor (Muscular contraction)</subject><subject>Ventral Thalamic Nuclei - surgery</subject><issn>2160-8288</issn><issn>2160-8288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpNkF1LwzAUhoMobsyBv0AC3njTmTRJm1zqvhQmXjjBu5I26ZbRJjNpEf-9GZviuTnn4nnfAw8A1xhNGCH0vnPbdkIzcQaGKc5QwlPOz__dAzAOYYfisFyklF2CAcEsY4zwIfiYbqXd6ACNhS9GNcZquPa6dR5Kq-BSmg4uXNO4L2M3cKb1Hj56GeG3zrR9IzvjLKwjPQ9B287I5hS_Ahe1bIIen_YIvC_m6-lTsnpdPk8fVkmFMRcJRhJpJipdSVVTjFGqdIYEF6Uiqs6RKlOlRJUSjnLKBck4yTUnpMportKyJiNwe-zde_fZ69AVO9d7G18WBAmGMeWERuruSFXeheB1Xey9aaX_LjAqDhaLg8UiWozozamwL1ut_sBfZ-QHgaJsQQ</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Higuchi, Masa-Aki</creator><creator>Roemmich, Ryan T</creator><creator>Martinez-Ramirez, Daniel</creator><creator>Roper, Jaimie A</creator><creator>Zukowski, Lisa A</creator><creator>Foote, Kelly D</creator><creator>Okun, Michael S</creator><creator>Hass, Chris J</creator><general>Ubiquity Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>2019</creationdate><title>Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor</title><author>Higuchi, Masa-Aki ; 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Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in persons with ET, suggesting a common pathophysiology distinct from that of upper extremity tremor. However, a causal link between midline tremor and gait impairment has not been established.
We investigated tremor and gait in 24 persons with ET before and after implantation of unilateral deep brain stimulation into the ventralis intermedius nucleus of the thalamus.
Stimulation significantly improved tremor in the targeted upper extremity and midline. However, gait was unaffected at the cohort level. Furthermore, improvement in midline tremor was not significantly associated with gait improvement.
These findings revealed that midline tremor and gait impairment may be dissociable in persons with ET.</abstract><cop>United States</cop><pub>Ubiquity Press</pub><pmid>31565538</pmid><doi>10.5334/tohm.469</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Ataxia Cohort Studies Deep Brain Stimulation Essential Tremor - complications Essential Tremor - therapy Female Gait Gait Disorders, Neurologic - etiology Gait Disorders, Neurologic - therapy Humans Hypotheses Male Middle Aged Movement disorders Pathophysiology Surgery Treatment Outcome Tremor (Muscular contraction) Ventral Thalamic Nuclei - surgery |
| title | Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor |
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