PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain function. Synaptic abnormalities, such as defects in the density and morphology of postsynaptic dendritic spines, underlie the pathology of various neuropsychiatric diso...

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Veröffentlicht in:	Dōngwùxué yánjiū 2024-05, Vol.45 (3), p.535-550
Hauptverfasser:	Yu, Laidong, Zeng, Fangfang, Fan, Mengshu, Zhang, Kexuan, Duan, Jingjing, Tan, Yalu, Liao, Panlin, Wen, Jin, Wang, Chenyu, Wang, Meilin, Yuan, Jialong, Pang, Xinxin, Huang, Yan, Zhang, Yangzhou, Li, Jia-Da, Zhang, Zhuohua, Hu, Zhonghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Actin Actin Cytoskeleton - metabolism Animals Behavior Bipolar disorder Brain Cadherins - genetics Cadherins - metabolism Cofilin Cytoskeleton Dendritic spines Dendritic Spines - metabolism Dendritic Spines - physiology Dendritic structure Disorders Emotional behavior Emotional disorders Gene Expression Regulation Hippocampus Kinases Laboratory animals LIM kinase Mental depression Mental disorders Mice Molecular modelling Mood Mood disorders Morphogenesis Morphology Neurons Pathology Phosphorylation Plasmids Postsynaptic density Proteins Protocadherin Protocadherins - genetics Protocadherins - metabolism Reagents rho-Associated Kinases - genetics rho-Associated Kinases - metabolism Serine Spine Synapses Synaptic density Synaptic depression Synaptogenesis Thermal cycling
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