IKZF2 Degradation: It′s Time to Take into Account it When Designing Cereblon‐Based PROTACs

Proteolysis‐targeting chimera (PROTAC) has become a very important means of protein degradation and a new way of disease treatment. In particular, PROTACs constructed with ligands for E3 ligase cereblon account for more than 90 % of the PROTACs currently in clinical research. Notably, CRBN ligands t...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2024-08, Vol.25 (16)
1. Verfasser:	Li, Minglei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradation Chimeras Degradation Ligands Medical treatment Proteins Proteolysis Substrates Ubiquitin-protein ligase
Online-Zugang:	Volltext
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