Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection
This review examines the latest developments in nanoscopic antibiotic formulations used to treat infections caused by bacteria. A wide range of nanocarrier platforms are discussed, including polymer-based nanoparticles (NPs), lipid-based vesicles, mesoporous silica, and other inorganic materials. Th...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2024-08, Vol.26 (8), p.190, Article 190 |
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| container_title | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology |
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| creator | Safaran, Negar Javadi, Shohreh Pourmadadi, Mehrab Ghaemi, Amirhossein Yazdian, Fatemeh Rashedi, Hamid Rahdar, Abbas Aboudzadeh, M. Ali |
| description | This review examines the latest developments in nanoscopic antibiotic formulations used to treat infections caused by bacteria. A wide range of nanocarrier platforms are discussed, including polymer-based nanoparticles (NPs), lipid-based vesicles, mesoporous silica, and other inorganic materials. The antibiotic levofloxacin (LVF) is predominantly used as a model drug given its broad-spectrum activity. Studies in this regard have evaluated drug loading and encapsulation efficiency (EE) using analytical techniques such as FTIR, DLS, and TEM. In vitro release kinetics was characterized through dialysis and fluorescence-based assays. Zone of inhibition and viability studies provided insights into antibacterial efficacy. Some approaches incorporated stimuli-responsive polymers or targeting ligands to facilitate controlled or targeted drug release. Overall, the nanocarriers demonstrated potential for sustained antibiotic levels, reduced dosing, and improved treatment of biofilms and intracellular infections compared to free drug administration. The review offers a comprehensive analysis of this promising field with implications for combating antibiotic resistance. |
| doi_str_mv | 10.1007/s11051-024-06087-z |
| format | Article |
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Ali</creator><creatorcontrib>Safaran, Negar ; Javadi, Shohreh ; Pourmadadi, Mehrab ; Ghaemi, Amirhossein ; Yazdian, Fatemeh ; Rashedi, Hamid ; Rahdar, Abbas ; Aboudzadeh, M. Ali</creatorcontrib><description>This review examines the latest developments in nanoscopic antibiotic formulations used to treat infections caused by bacteria. A wide range of nanocarrier platforms are discussed, including polymer-based nanoparticles (NPs), lipid-based vesicles, mesoporous silica, and other inorganic materials. The antibiotic levofloxacin (LVF) is predominantly used as a model drug given its broad-spectrum activity. Studies in this regard have evaluated drug loading and encapsulation efficiency (EE) using analytical techniques such as FTIR, DLS, and TEM. In vitro release kinetics was characterized through dialysis and fluorescence-based assays. Zone of inhibition and viability studies provided insights into antibacterial efficacy. Some approaches incorporated stimuli-responsive polymers or targeting ligands to facilitate controlled or targeted drug release. Overall, the nanocarriers demonstrated potential for sustained antibiotic levels, reduced dosing, and improved treatment of biofilms and intracellular infections compared to free drug administration. 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Ali</creatorcontrib><title>Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection</title><title>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</title><addtitle>J Nanopart Res</addtitle><description>This review examines the latest developments in nanoscopic antibiotic formulations used to treat infections caused by bacteria. A wide range of nanocarrier platforms are discussed, including polymer-based nanoparticles (NPs), lipid-based vesicles, mesoporous silica, and other inorganic materials. The antibiotic levofloxacin (LVF) is predominantly used as a model drug given its broad-spectrum activity. Studies in this regard have evaluated drug loading and encapsulation efficiency (EE) using analytical techniques such as FTIR, DLS, and TEM. In vitro release kinetics was characterized through dialysis and fluorescence-based assays. 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The review offers a comprehensive analysis of this promising field with implications for combating antibiotic resistance.</description><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial diseases</subject><subject>Bacterial infections</subject><subject>Bioavailability</subject><subject>Biofilms</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical engineering</subject><subject>Chemistry and Materials Science</subject><subject>Dialysis</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>FDA approval</subject><subject>Infections</subject><subject>Inorganic Chemistry</subject><subject>Inorganic materials</subject><subject>Lasers</subject><subject>Levofloxacin</subject><subject>Lipids</subject><subject>Materials Science</subject><subject>Molecular structure</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Polymers</subject><subject>Quantum dots</subject><subject>Review</subject><subject>Sexually transmitted diseases</subject><subject>Silica</subject><subject>STD</subject><issn>1388-0764</issn><issn>1572-896X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kMFqGzEQhpfSQFMnL9CToGc1kla7ko7BtE0g0EsDuYmxNHJk1pIrrU2dvHzUOJBbTzMM__8NfF33hbNvnDF1VTlnA6dMSMpGphV9-tCd80EJqs348LHtvdaUqVF-6j7XumGMj8KI8-752h8gOawkJrLL03GLJToCyZOUE32_JEjZQSkRSyUhFzI_ItnCOsUQ0ROPUzxgOZIcyISHHKb8F1xjwhpiqjNZgZsbCKb2KKCbY04X3VmAqeLl21x09z--_17e0LtfP2-X13fUCSlnKv0YdFgZY7gfmQEDAYUYpfRKaNmjUwijXmnpJGiuvPNSSgQxSKU0G6BfdF9P3F3Jf_ZYZ7vJ-5LaS9sz0yvGh960lDilXMm1Fgx2V-IWytFyZv9JtifJtkm2r5LtUyv1p1Jt4bTG8o7-T-sFAm-Cyw</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Safaran, Negar</creator><creator>Javadi, Shohreh</creator><creator>Pourmadadi, Mehrab</creator><creator>Ghaemi, Amirhossein</creator><creator>Yazdian, Fatemeh</creator><creator>Rashedi, Hamid</creator><creator>Rahdar, Abbas</creator><creator>Aboudzadeh, M. 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| subjects | Antibiotic resistance Antibiotics Bacteria Bacterial diseases Bacterial infections Bioavailability Biofilms Characterization and Evaluation of Materials Chemical engineering Chemistry and Materials Science Dialysis Drug delivery systems Drugs FDA approval Infections Inorganic Chemistry Inorganic materials Lasers Levofloxacin Lipids Materials Science Molecular structure Nanoparticles Nanotechnology Optical Devices Optics Photonics Physical Chemistry Polymers Quantum dots Review Sexually transmitted diseases Silica STD |
| title | Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection |
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