Characterization and Pathogenicity of Novel Reassortment H6N6 Avian Influenza Viruses in Southern China
The H6N6 avian influenza virus (AIV) subtype is one of the most frequently isolated subtypes in poultry, and it has a broad host range. Some strains can overcome species barriers for transmission and infect humans. Increased affinity for human‐type receptors is a key factor in this process. In this...
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| creator | Zhu, Puduo He, Xudong Chen, Yiquan Yan, Zhuanqiang Li, Qunhui Zhou, Qi Lin, Wencheng Chen, Feng |
| description | The H6N6 avian influenza virus (AIV) subtype is one of the most frequently isolated subtypes in poultry, and it has a broad host range. Some strains can overcome species barriers for transmission and infect humans. Increased affinity for human‐type receptors is a key factor in this process. In this study, two H6N6 AIV strains originating from five different clades, in which amino acid 226 of hemagglutinin was mutated from glutamine to lysine, were isolated from ducks. The receptor‐binding preference and pathogenicity of the two strains in poultry and mice were evaluated. The results indicated that the DK/GD/W3 strain can bind to both α ‐2,6 and α ‐2,3 receptors, whereas the DK/GD/L31 strain maintained affinity toward avian‐origin α ‐2,3 receptors, highlighting differences in receptor tropism and pathogenicity to different hosts for two H6N6 strains with the same genetic background. These findings have revealed the complex recombination characteristics and molecular characteristics of H6N6 circulating strains in the environment and underscored the importance of continuous surveillance of this subtype for livestock and poultry health as well as human safety. |
| doi_str_mv | 10.1155/2024/4005909 |
| format | Article |
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Some strains can overcome species barriers for transmission and infect humans. Increased affinity for human‐type receptors is a key factor in this process. In this study, two H6N6 AIV strains originating from five different clades, in which amino acid 226 of hemagglutinin was mutated from glutamine to lysine, were isolated from ducks. The receptor‐binding preference and pathogenicity of the two strains in poultry and mice were evaluated. The results indicated that the DK/GD/W3 strain can bind to both α ‐2,6 and α ‐2,3 receptors, whereas the DK/GD/L31 strain maintained affinity toward avian‐origin α ‐2,3 receptors, highlighting differences in receptor tropism and pathogenicity to different hosts for two H6N6 strains with the same genetic background. These findings have revealed the complex recombination characteristics and molecular characteristics of H6N6 circulating strains in the environment and underscored the importance of continuous surveillance of this subtype for livestock and poultry health as well as human safety.</description><identifier>ISSN: 1865-1674</identifier><identifier>EISSN: 1865-1682</identifier><identifier>DOI: 10.1155/2024/4005909</identifier><language>eng</language><publisher>Berlin: Hindawi Limited</publisher><subject>Affinity ; Amino acids ; Antibodies ; Aquatic birds ; Avian flu ; Disease transmission ; Evolution & development ; Genomes ; Glutamine ; Hemagglutinins ; Host range ; Influenza ; Laboratory animals ; Livestock ; Lungs ; Lysine ; Pathogenicity ; Pathogens ; Phylogenetics ; Poultry ; Receptors ; Small intestine ; Spleen ; Strains (organisms) ; Throat ; Tropism ; Viruses</subject><ispartof>Transboundary and emerging diseases, 2024-01, Vol.2024 (1)</ispartof><rights>Copyright © 2024 Puduo Zhu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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Some strains can overcome species barriers for transmission and infect humans. Increased affinity for human‐type receptors is a key factor in this process. In this study, two H6N6 AIV strains originating from five different clades, in which amino acid 226 of hemagglutinin was mutated from glutamine to lysine, were isolated from ducks. The receptor‐binding preference and pathogenicity of the two strains in poultry and mice were evaluated. The results indicated that the DK/GD/W3 strain can bind to both α ‐2,6 and α ‐2,3 receptors, whereas the DK/GD/L31 strain maintained affinity toward avian‐origin α ‐2,3 receptors, highlighting differences in receptor tropism and pathogenicity to different hosts for two H6N6 strains with the same genetic background. These findings have revealed the complex recombination characteristics and molecular characteristics of H6N6 circulating strains in the environment and underscored the importance of continuous surveillance of this subtype for livestock and poultry health as well as human safety.</description><subject>Affinity</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Aquatic birds</subject><subject>Avian flu</subject><subject>Disease transmission</subject><subject>Evolution & development</subject><subject>Genomes</subject><subject>Glutamine</subject><subject>Hemagglutinins</subject><subject>Host range</subject><subject>Influenza</subject><subject>Laboratory animals</subject><subject>Livestock</subject><subject>Lungs</subject><subject>Lysine</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Phylogenetics</subject><subject>Poultry</subject><subject>Receptors</subject><subject>Small intestine</subject><subject>Spleen</subject><subject>Strains (organisms)</subject><subject>Throat</subject><subject>Tropism</subject><subject>Viruses</subject><issn>1865-1674</issn><issn>1865-1682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNo9kM9rwjAAhcPYYM7ttj8gsOs6k6ZJk6OUbQrixn5dQ5qmNqKJS1JB__opyk7vHT7egw-Ae4yeMKZ0lKO8GBUIUYHEBRhgzmiGGc8v_3tZXIObGJcIMSQYHYBF1amgdDLB7lWy3kHlGviuUucXxllt0w76Fs791qzgh1Ex-pDWxiU4YXMGx1urHJy6dtUbt1fwx4Y-mgitg5--T50JDladdeoWXLVqFc3dOYfg--X5q5pks7fXaTWeZRpznjJBhWJlTQivS01KwVrMa055jYqiELxsqG6IwFhpwrThghPeYIHKXGOqRdOSIXg47W6C_-1NTHLp--AOl5IggQnlgogD9XiidPAxBtPKTbBrFXYSI3lUKY8q5Vkl-QONzWVj</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Zhu, Puduo</creator><creator>He, Xudong</creator><creator>Chen, Yiquan</creator><creator>Yan, Zhuanqiang</creator><creator>Li, Qunhui</creator><creator>Zhou, Qi</creator><creator>Lin, Wencheng</creator><creator>Chen, Feng</creator><general>Hindawi Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X2</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0009-0006-5583-8195</orcidid><orcidid>https://orcid.org/0000-0001-8318-7971</orcidid><orcidid>https://orcid.org/0009-0004-2638-7343</orcidid></search><sort><creationdate>20240101</creationdate><title>Characterization and Pathogenicity of Novel Reassortment H6N6 Avian Influenza Viruses in Southern China</title><author>Zhu, Puduo ; He, Xudong ; Chen, Yiquan ; Yan, Zhuanqiang ; Li, Qunhui ; Zhou, Qi ; Lin, Wencheng ; Chen, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c188t-959a67b338b7c3796f18b858b0444987d5cd3911ac36ce89838d19072c15c9df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Affinity</topic><topic>Amino acids</topic><topic>Antibodies</topic><topic>Aquatic birds</topic><topic>Avian flu</topic><topic>Disease transmission</topic><topic>Evolution & development</topic><topic>Genomes</topic><topic>Glutamine</topic><topic>Hemagglutinins</topic><topic>Host range</topic><topic>Influenza</topic><topic>Laboratory animals</topic><topic>Livestock</topic><topic>Lungs</topic><topic>Lysine</topic><topic>Pathogenicity</topic><topic>Pathogens</topic><topic>Phylogenetics</topic><topic>Poultry</topic><topic>Receptors</topic><topic>Small intestine</topic><topic>Spleen</topic><topic>Strains (organisms)</topic><topic>Throat</topic><topic>Tropism</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Puduo</creatorcontrib><creatorcontrib>He, Xudong</creatorcontrib><creatorcontrib>Chen, Yiquan</creatorcontrib><creatorcontrib>Yan, Zhuanqiang</creatorcontrib><creatorcontrib>Li, Qunhui</creatorcontrib><creatorcontrib>Zhou, Qi</creatorcontrib><creatorcontrib>Lin, Wencheng</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Transboundary and emerging diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Puduo</au><au>He, Xudong</au><au>Chen, Yiquan</au><au>Yan, Zhuanqiang</au><au>Li, Qunhui</au><au>Zhou, Qi</au><au>Lin, Wencheng</au><au>Chen, Feng</au><au>Wu, Zongfu</au><au>Zongfu Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization and Pathogenicity of Novel Reassortment H6N6 Avian Influenza Viruses in Southern China</atitle><jtitle>Transboundary and emerging diseases</jtitle><date>2024-01-01</date><risdate>2024</risdate><volume>2024</volume><issue>1</issue><issn>1865-1674</issn><eissn>1865-1682</eissn><abstract>The H6N6 avian influenza virus (AIV) subtype is one of the most frequently isolated subtypes in poultry, and it has a broad host range. Some strains can overcome species barriers for transmission and infect humans. Increased affinity for human‐type receptors is a key factor in this process. In this study, two H6N6 AIV strains originating from five different clades, in which amino acid 226 of hemagglutinin was mutated from glutamine to lysine, were isolated from ducks. The receptor‐binding preference and pathogenicity of the two strains in poultry and mice were evaluated. The results indicated that the DK/GD/W3 strain can bind to both α ‐2,6 and α ‐2,3 receptors, whereas the DK/GD/L31 strain maintained affinity toward avian‐origin α ‐2,3 receptors, highlighting differences in receptor tropism and pathogenicity to different hosts for two H6N6 strains with the same genetic background. These findings have revealed the complex recombination characteristics and molecular characteristics of H6N6 circulating strains in the environment and underscored the importance of continuous surveillance of this subtype for livestock and poultry health as well as human safety.</abstract><cop>Berlin</cop><pub>Hindawi Limited</pub><doi>10.1155/2024/4005909</doi><orcidid>https://orcid.org/0009-0006-5583-8195</orcidid><orcidid>https://orcid.org/0000-0001-8318-7971</orcidid><orcidid>https://orcid.org/0009-0004-2638-7343</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Affinity Amino acids Antibodies Aquatic birds Avian flu Disease transmission Evolution & development Genomes Glutamine Hemagglutinins Host range Influenza Laboratory animals Livestock Lungs Lysine Pathogenicity Pathogens Phylogenetics Poultry Receptors Small intestine Spleen Strains (organisms) Throat Tropism Viruses |
| title | Characterization and Pathogenicity of Novel Reassortment H6N6 Avian Influenza Viruses in Southern China |
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