Neuroprotection and axon regeneration in glaucoma models by gene therapy using modified tyrosine kinase receptors

Aims/Purpose: To determine whether gene therapy using the modified tyrosine kinase receptors (insulin receptor or TrkB) can protect retinal ganglion cells (RGCs) and stimulate axon regeneration in glaucoma model mice. Methods: To examine the effects on the signalling pathways, Cos7 cells were transf...

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Veröffentlicht in:	Acta ophthalmologica (Oxford, England) England), 2024-01, Vol.102 (S279), p.n/a
Hauptverfasser:	Harada, Takayuki, Namekata, Kazuhiko, Sotozono, Akiko, Shinozaki, Youichi, Guo, Xiaoli, Harada, Chikako
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Cholera toxin Dendrites Extracellular signal-regulated kinase Gene therapy Glaucoma Image processing Insulin Insulin receptors Intracellular signalling Kinases Neuroprotection Optic nerve Phosphorylation Regeneration Retina Retinal ganglion cells Signal transduction Transfection Trk receptors TrkB receptors
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