SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids

Blood vessels show various COVID-19-related conditions including thrombosis and cytokine propagation. Existing in vitro blood vessel models cannot represent the consequent changes in the vascular structure or determine the initial infection site, making it difficult to evaluate how epithelial and en...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Lab on a chip 2024-08, Vol.24 (16), p.3863-3879
Hauptverfasser:	Fujimoto, Kazuya, Kameda, Yoshikazu, Nagano, Yuta, Deguchi, Sayaka, Yamamoto, Takuya, Krol, Rafal P, Gee, Peter, Matsumura, Yasufumi, Okamoto, Toru, Nagao, Miki, Takayama, Kazuo, Yokokawa, Ryuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood vessels Bronchi - cytology Coculture Techniques COVID-19 - metabolism COVID-19 - virology Cytokines Damage Epithelium Humans Interferon Interferon Type I - metabolism Lab-On-A-Chip Devices Microphysiological Systems Organoids - metabolism Organoids - pathology Organoids - virology Protective structures SARS-CoV-2 Thrombosis Viral diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!