Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity

Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor‐specific conditions, especially glucose deprivation, activate a signaling pathway call...

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Veröffentlicht in:	Journal of cellular physiology 2010-07, Vol.224 (1), p.33-40
Hauptverfasser:	Kim, Ju-Young, Hwang, Ji-Hwan, Cha, Mi-Ran, Yoon, Mi-Young, Son, Eun-Soon, Tomida, Akihiro, Ko, Bosung, Song, Si-Whan, Shin-ya, Kazuo, Hwang, Yong-il, Park, Hae-Ryong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic drugs Antitumor activity Antitumor agents Apoptosis Apoptosis - drug effects Caspase Cell survival Cell Survival - drug effects Cell viability Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cytotoxicity Deprivation Dose-Response Relationship, Drug Furans - pharmacology Gene expression Gene Expression Regulation, Neoplastic - drug effects Glucose Glucose - deficiency Heat shock proteins HeLa Cells HT29 Cells Humans Hypoxia Lignans - pharmacology Mice Mice, Nude Microenvironments Phosphorylation Protein folding Proteins Signal transduction Solid tumors Stress proteins Time Factors Tumor Burden - drug effects Tumors Unfolded Protein Response - drug effects Unfolded Protein Response - genetics Xenograft Model Antitumor Assays Xenotransplantation
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