Anacyclus pyrethrum extracts: examination of bioactive compounds and therapeutic implications through in vivo, in vitro, and in silico assays
Anacyclus pyrethrum, a native Algerian medicinal plant, demonstrates notable therapeutic efficacy. The bioactive profile of the Anacyclus pyrethrum extract was examined using HPLC-UV-VIS, which showed a high concentration of phenolic compounds (33.46 ± 0.57 mg EAG/g EP) and flavonoids (11.08 ± 0.24...
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| Veröffentlicht in: | Italian journal of food science 2024-07, Vol.36 (3), p.80-94 |
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| creator | Elhouda-Mekhadmi, Nour Mlik, Randa Abid, Asma Adaika, Aicha Bentahar, Assia Amour, Safia Ben Mouane, Aicha Boussebaa, Walid Ramdani, Messaoud Amara, Djilani Ghemam Atoki, Ayomide Victor Sawicka, Barbara Ahmad, Sheikh F Attia, Sabry M Messaoudi, Mohammed |
| description | Anacyclus pyrethrum, a native Algerian medicinal plant, demonstrates notable therapeutic efficacy. The bioactive profile of the Anacyclus pyrethrum extract was examined using HPLC-UV-VIS, which showed a high concentration of phenolic compounds (33.46 ± 0.57 mg EAG/g EP) and flavonoids (11.08 ± 0.24 mg E Qu/g EP). The Anacyclus pyrethrum extract exhibited significant antioxidant activity in iron chelation (IC50 = 0.019 ± 0.0006 mg/ml) DPPH (IC50 = 0.142± 0.001 mg/ml), ABTS+ (IC50 = 0.079 ± 0.0005 mg/ml) and OH (IC50 = 0.845 ± 0.052mg/ml) radicals. Anti-inflammatory investigations were conducted using both in vitro and in silico methods. The in vitro testing involved evaluating the denaturation of egg albumin and BSA, while the in silico tests focused on measuring the effect of caffeic acid on the COX-2 protein. The anti-inflammatory capacity of the substance was similar to that of Aspirin, with a value of 76.1 ± 1.04% compared to Aspirin’s 81.11 ± 1.6%. Our extract exhibited a fatal dose (LD50) of 45.847 ± 1.661 mg/ml and showed significant antibacterial activity with minimum inhibitory concentrations (MICs) ranging from 2.5 to 27.5 mg/ml. The findings emphasize the wide range of medicinal uses of Anacyclus pyrethrum, underscoring its significance in both traditional and modern pharmacology. |
| doi_str_mv | 10.15586/ijfs.v36i3.2627 |
| format | Article |
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The bioactive profile of the Anacyclus pyrethrum extract was examined using HPLC-UV-VIS, which showed a high concentration of phenolic compounds (33.46 ± 0.57 mg EAG/g EP) and flavonoids (11.08 ± 0.24 mg E Qu/g EP). The Anacyclus pyrethrum extract exhibited significant antioxidant activity in iron chelation (IC50 = 0.019 ± 0.0006 mg/ml) DPPH (IC50 = 0.142± 0.001 mg/ml), ABTS+ (IC50 = 0.079 ± 0.0005 mg/ml) and OH (IC50 = 0.845 ± 0.052mg/ml) radicals. Anti-inflammatory investigations were conducted using both in vitro and in silico methods. The in vitro testing involved evaluating the denaturation of egg albumin and BSA, while the in silico tests focused on measuring the effect of caffeic acid on the COX-2 protein. The anti-inflammatory capacity of the substance was similar to that of Aspirin, with a value of 76.1 ± 1.04% compared to Aspirin’s 81.11 ± 1.6%. Our extract exhibited a fatal dose (LD50) of 45.847 ± 1.661 mg/ml and showed significant antibacterial activity with minimum inhibitory concentrations (MICs) ranging from 2.5 to 27.5 mg/ml. The findings emphasize the wide range of medicinal uses of Anacyclus pyrethrum, underscoring its significance in both traditional and modern pharmacology.</description><identifier>ISSN: 1120-1770</identifier><identifier>EISSN: 1120-1770</identifier><identifier>EISSN: 2239-5687</identifier><identifier>DOI: 10.15586/ijfs.v36i3.2627</identifier><language>eng</language><publisher>Pinerolo: Chiriotti Editori S.r.l</publisher><subject>Acids ; Albumin ; Anacyclus ; Analysis ; Antibacterial activity ; Antioxidants ; Aspirin ; Barley ; Bioactive compounds ; Biodiversity ; Biological activity ; Caffeic acid ; Chelation ; Denaturation ; Drug dosages ; Ethylenediaminetetraacetic acid ; Flavonoids ; Flowers & plants ; Health aspects ; Herbal medicine ; High performance liquid chromatography ; In vitro methods and tests ; In vivo methods and tests ; Inflammation ; Insecticides ; Isoflavones ; Liquid chromatography ; Medical research ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Mortality ; Pharmacology ; Phenolic compounds ; Phenols ; Plant extracts ; Protein denaturation ; Proteins ; Solvents</subject><ispartof>Italian journal of food science, 2024-07, Vol.36 (3), p.80-94</ispartof><rights>COPYRIGHT 2024 Chiriotti Editori S.r.l.</rights><rights>2024. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-3536-6358</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Elhouda-Mekhadmi, Nour</creatorcontrib><creatorcontrib>Mlik, Randa</creatorcontrib><creatorcontrib>Abid, Asma</creatorcontrib><creatorcontrib>Adaika, Aicha</creatorcontrib><creatorcontrib>Bentahar, Assia</creatorcontrib><creatorcontrib>Amour, Safia Ben</creatorcontrib><creatorcontrib>Mouane, Aicha</creatorcontrib><creatorcontrib>Boussebaa, Walid</creatorcontrib><creatorcontrib>Ramdani, Messaoud</creatorcontrib><creatorcontrib>Amara, Djilani Ghemam</creatorcontrib><creatorcontrib>Atoki, Ayomide Victor</creatorcontrib><creatorcontrib>Sawicka, Barbara</creatorcontrib><creatorcontrib>Ahmad, Sheikh F</creatorcontrib><creatorcontrib>Attia, Sabry M</creatorcontrib><creatorcontrib>Messaoudi, Mohammed</creatorcontrib><title>Anacyclus pyrethrum extracts: examination of bioactive compounds and therapeutic implications through in vivo, in vitro, and in silico assays</title><title>Italian journal of food science</title><description>Anacyclus pyrethrum, a native Algerian medicinal plant, demonstrates notable therapeutic efficacy. The bioactive profile of the Anacyclus pyrethrum extract was examined using HPLC-UV-VIS, which showed a high concentration of phenolic compounds (33.46 ± 0.57 mg EAG/g EP) and flavonoids (11.08 ± 0.24 mg E Qu/g EP). The Anacyclus pyrethrum extract exhibited significant antioxidant activity in iron chelation (IC50 = 0.019 ± 0.0006 mg/ml) DPPH (IC50 = 0.142± 0.001 mg/ml), ABTS+ (IC50 = 0.079 ± 0.0005 mg/ml) and OH (IC50 = 0.845 ± 0.052mg/ml) radicals. Anti-inflammatory investigations were conducted using both in vitro and in silico methods. The in vitro testing involved evaluating the denaturation of egg albumin and BSA, while the in silico tests focused on measuring the effect of caffeic acid on the COX-2 protein. The anti-inflammatory capacity of the substance was similar to that of Aspirin, with a value of 76.1 ± 1.04% compared to Aspirin’s 81.11 ± 1.6%. Our extract exhibited a fatal dose (LD50) of 45.847 ± 1.661 mg/ml and showed significant antibacterial activity with minimum inhibitory concentrations (MICs) ranging from 2.5 to 27.5 mg/ml. The findings emphasize the wide range of medicinal uses of Anacyclus pyrethrum, underscoring its significance in both traditional and modern pharmacology.</description><subject>Acids</subject><subject>Albumin</subject><subject>Anacyclus</subject><subject>Analysis</subject><subject>Antibacterial activity</subject><subject>Antioxidants</subject><subject>Aspirin</subject><subject>Barley</subject><subject>Bioactive compounds</subject><subject>Biodiversity</subject><subject>Biological activity</subject><subject>Caffeic acid</subject><subject>Chelation</subject><subject>Denaturation</subject><subject>Drug dosages</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Flavonoids</subject><subject>Flowers & plants</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>High performance liquid chromatography</subject><subject>In vitro methods and tests</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Insecticides</subject><subject>Isoflavones</subject><subject>Liquid chromatography</subject><subject>Medical research</subject><subject>Medicinal plants</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Mortality</subject><subject>Pharmacology</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Plant extracts</subject><subject>Protein 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Nour</creator><creator>Mlik, Randa</creator><creator>Abid, Asma</creator><creator>Adaika, Aicha</creator><creator>Bentahar, Assia</creator><creator>Amour, Safia Ben</creator><creator>Mouane, Aicha</creator><creator>Boussebaa, Walid</creator><creator>Ramdani, Messaoud</creator><creator>Amara, Djilani Ghemam</creator><creator>Atoki, Ayomide Victor</creator><creator>Sawicka, Barbara</creator><creator>Ahmad, Sheikh F</creator><creator>Attia, Sabry M</creator><creator>Messaoudi, Mohammed</creator><general>Chiriotti Editori S.r.l</general><general>Codon 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Amour, Safia Ben ; Mouane, Aicha ; Boussebaa, Walid ; Ramdani, Messaoud ; Amara, Djilani Ghemam ; Atoki, Ayomide Victor ; Sawicka, Barbara ; Ahmad, Sheikh F ; Attia, Sabry M ; Messaoudi, Mohammed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c263t-1c995384d7e6bb5f971bd56401b705a9dc22dbdd1d506eb866300a7edc55e6943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acids</topic><topic>Albumin</topic><topic>Anacyclus</topic><topic>Analysis</topic><topic>Antibacterial activity</topic><topic>Antioxidants</topic><topic>Aspirin</topic><topic>Barley</topic><topic>Bioactive compounds</topic><topic>Biodiversity</topic><topic>Biological activity</topic><topic>Caffeic acid</topic><topic>Chelation</topic><topic>Denaturation</topic><topic>Drug dosages</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Flavonoids</topic><topic>Flowers & plants</topic><topic>Health 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science</jtitle><date>2024-07-01</date><risdate>2024</risdate><volume>36</volume><issue>3</issue><spage>80</spage><epage>94</epage><pages>80-94</pages><issn>1120-1770</issn><eissn>1120-1770</eissn><eissn>2239-5687</eissn><abstract>Anacyclus pyrethrum, a native Algerian medicinal plant, demonstrates notable therapeutic efficacy. The bioactive profile of the Anacyclus pyrethrum extract was examined using HPLC-UV-VIS, which showed a high concentration of phenolic compounds (33.46 ± 0.57 mg EAG/g EP) and flavonoids (11.08 ± 0.24 mg E Qu/g EP). The Anacyclus pyrethrum extract exhibited significant antioxidant activity in iron chelation (IC50 = 0.019 ± 0.0006 mg/ml) DPPH (IC50 = 0.142± 0.001 mg/ml), ABTS+ (IC50 = 0.079 ± 0.0005 mg/ml) and OH (IC50 = 0.845 ± 0.052mg/ml) radicals. Anti-inflammatory investigations were conducted using both in vitro and in silico methods. The in vitro testing involved evaluating the denaturation of egg albumin and BSA, while the in silico tests focused on measuring the effect of caffeic acid on the COX-2 protein. The anti-inflammatory capacity of the substance was similar to that of Aspirin, with a value of 76.1 ± 1.04% compared to Aspirin’s 81.11 ± 1.6%. Our extract exhibited a fatal dose (LD50) of 45.847 ± 1.661 mg/ml and showed significant antibacterial activity with minimum inhibitory concentrations (MICs) ranging from 2.5 to 27.5 mg/ml. The findings emphasize the wide range of medicinal uses of Anacyclus pyrethrum, underscoring its significance in both traditional and modern pharmacology.</abstract><cop>Pinerolo</cop><pub>Chiriotti Editori S.r.l</pub><doi>10.15586/ijfs.v36i3.2627</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-3536-6358</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Albumin Anacyclus Analysis Antibacterial activity Antioxidants Aspirin Barley Bioactive compounds Biodiversity Biological activity Caffeic acid Chelation Denaturation Drug dosages Ethylenediaminetetraacetic acid Flavonoids Flowers & plants Health aspects Herbal medicine High performance liquid chromatography In vitro methods and tests In vivo methods and tests Inflammation Insecticides Isoflavones Liquid chromatography Medical research Medicinal plants Medicine, Botanic Medicine, Herbal Mortality Pharmacology Phenolic compounds Phenols Plant extracts Protein denaturation Proteins Solvents |
| title | Anacyclus pyrethrum extracts: examination of bioactive compounds and therapeutic implications through in vivo, in vitro, and in silico assays |
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