Synthesis, Antiradical and Anticholinesterase Аctivity of Kетоamides of N-Substituted α,β-Dehydroamino Acids and Corresponding Imidazol-4-ones

A series of N -substituted α,β-dehydroamino acids N -benzoylmethylamides was prepared starting from substituted 2-phenyl-4-benzylidene-5-oxazolones. The ketoamides were used to the synthesis of substituted 4-imidazolones in the presence of 1,1,1,3,3,3-hexamethyldisilazane as a dehydrating agent. The...

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Veröffentlicht in:	Russian journal of general chemistry 2024-05, Vol.94 (5), p.1055-1064
Hauptverfasser:	Agababyan, A. G., Hovhannisyan, N. A., Tosunyan, S. R., Makichyan, A. T., Hovhannisyan, A. A., Shahkhatuni, A. A., Topuzyan, V. O.
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Schlagworte:	Benzamide Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Dehydration Heterocyclic compounds Hydrazines Substitutes
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creator	Agababyan, A. G. Hovhannisyan, N. A. Tosunyan, S. R. Makichyan, A. T. Hovhannisyan, A. A. Shahkhatuni, A. A. Topuzyan, V. O.
description	A series of N -substituted α,β-dehydroamino acids N -benzoylmethylamides was prepared starting from substituted 2-phenyl-4-benzylidene-5-oxazolones. The ketoamides were used to the synthesis of substituted 4-imidazolones in the presence of 1,1,1,3,3,3-hexamethyldisilazane as a dehydrating agent. The corresponding amido alcohol was obtained by reduction of ( Z )- N -{3-oxo-3-[(2-oxo-2-phenylethyl)amino]-1-phenylprop-1-en-2-yl}benzamide by sodium borohydride, and diazine was obtained by its reaction with hydrazine. Antiradical and anticholinesterase properties of the synthesized compounds were studied.
doi_str_mv	10.1134/S1070363224050062
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subjects	Benzamide Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Dehydration Heterocyclic compounds Hydrazines Substitutes
title	Synthesis, Antiradical and Anticholinesterase Аctivity of Kетоamides of N-Substituted α,β-Dehydroamino Acids and Corresponding Imidazol-4-ones
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