Synthesis of silver nanocomposite semi-interpenetrating polymer network hydrogel based on sodium alginate-g-polyacrylamide for using in Epirubicin anticancer drug release
This study presents the synthesis and characterization of a silver nanocomposite semi-interpenetrating polymer network (semi-IPN) hydrogel using sodium alginate- g -polyacrylamide (Ag@Alg-g-PAAm). The silver nanoparticles were synthesized in the presence of sodium alginate and sunlight. The first ne...
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| Veröffentlicht in: | Journal of polymer research 2024-07, Vol.31 (7), Article 210 |
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| container_title | Journal of polymer research |
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| creator | Bardajee, Ghasem Rezanejade Dianatnejad, Nastaran Mahmoodi, Nosrat O. Ghasemzadeh, Hossein |
| description | This study presents the synthesis and characterization of a silver nanocomposite semi-interpenetrating polymer network (semi-IPN) hydrogel using sodium alginate-
g
-polyacrylamide (Ag@Alg-g-PAAm). The silver nanoparticles were synthesized in the presence of sodium alginate and sunlight. The first network was formed thermally with N, N´-Methylenebisacrylamide as a crosslinker, and the second network was created using calcium chloride for networking of sodium alginate. The resulting Ag@Alg-g-PAAm product was characterized using FT-IR, FE-SEM, EDX, TEM, and TG analysis. In addition, in vitro drug release studies were conducted for Epirubicin, an anticancer drug, at pHs 5.4 and 7.4 at 37 ˚C. The release of Epirubicin from Ag@Alg-g-PAAm was higher at pH 5.4 compared to pH 7.4. These findings align with the swelling behavior of Ag@Alg-g-PAAm, where greater swelling occurred at pH 5.4. |
| doi_str_mv | 10.1007/s10965-024-04020-5 |
| format | Article |
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g
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g
-polyacrylamide (Ag@Alg-g-PAAm). The silver nanoparticles were synthesized in the presence of sodium alginate and sunlight. The first network was formed thermally with N, N´-Methylenebisacrylamide as a crosslinker, and the second network was created using calcium chloride for networking of sodium alginate. The resulting Ag@Alg-g-PAAm product was characterized using FT-IR, FE-SEM, EDX, TEM, and TG analysis. In addition, in vitro drug release studies were conducted for Epirubicin, an anticancer drug, at pHs 5.4 and 7.4 at 37 ˚C. The release of Epirubicin from Ag@Alg-g-PAAm was higher at pH 5.4 compared to pH 7.4. These findings align with the swelling behavior of Ag@Alg-g-PAAm, where greater swelling occurred at pH 5.4.</description><subject>Calcium chloride</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Hydrogels</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Interpenetrating networks</subject><subject>Methylene bisacrylamide</subject><subject>Nanocomposites</subject><subject>Original Paper</subject><subject>Polyacrylamide</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Silver</subject><subject>Sodium alginate</subject><subject>Swelling</subject><issn>1022-9760</issn><issn>1572-8935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1jAQhSNEJUrLC3RlibVhMvmdyxJV5SJVYgGsrYkzSV0SO9gOKK_EU9bhR2LHakaac76RzimKmxLelADN21hCVysJeJJwAgSpnhWXpWpQtl2lnucdEGXX1PCieBnjI4BSTd1eFr-_7C49cLRR-FFEO__kIBw5b_yy-mgTi8iLldYlDis7ToGSdZNY_bwvh5bTLx--i4d9CH7iWfQUeRDeiegHuy2C5sk6SiwneXjIhH2mxQ4sRh_EFg-YdeJutWHrrckruWQNOZPpQ9gmEXjmDL0uLkaaI7_6O6-Kb-_vvt5-lPefP3y6fXcvDQIk2XU4Ap1aaqkBHMey7BXSoE7YjGOF-QhYt4xN36JRPRmqc0R1BwqBoCurq-L1mbsG_2PjmPSj34LLL3UF7REcYpdVeFaZ4GMMPOo12IXCrkvQRyf63InOneg_nWiVTdXZFLPYTRz-of_jegILD5Ox</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Bardajee, Ghasem Rezanejade</creator><creator>Dianatnejad, Nastaran</creator><creator>Mahmoodi, Nosrat O.</creator><creator>Ghasemzadeh, Hossein</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-7331-0059</orcidid></search><sort><creationdate>20240701</creationdate><title>Synthesis of silver nanocomposite semi-interpenetrating polymer network hydrogel based on sodium alginate-g-polyacrylamide for using in Epirubicin anticancer drug release</title><author>Bardajee, Ghasem Rezanejade ; Dianatnejad, Nastaran ; Mahmoodi, Nosrat O. ; Ghasemzadeh, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c200t-992f0a48a8a702ff11b52ad5427ff322f00268e27b82c5baca6935690520a0913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Calcium chloride</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Hydrogels</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Interpenetrating networks</topic><topic>Methylene bisacrylamide</topic><topic>Nanocomposites</topic><topic>Original Paper</topic><topic>Polyacrylamide</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Silver</topic><topic>Sodium alginate</topic><topic>Swelling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bardajee, Ghasem Rezanejade</creatorcontrib><creatorcontrib>Dianatnejad, Nastaran</creatorcontrib><creatorcontrib>Mahmoodi, Nosrat O.</creatorcontrib><creatorcontrib>Ghasemzadeh, Hossein</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of polymer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bardajee, Ghasem Rezanejade</au><au>Dianatnejad, Nastaran</au><au>Mahmoodi, Nosrat O.</au><au>Ghasemzadeh, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of silver nanocomposite semi-interpenetrating polymer network hydrogel based on sodium alginate-g-polyacrylamide for using in Epirubicin anticancer drug release</atitle><jtitle>Journal of polymer research</jtitle><stitle>J Polym Res</stitle><date>2024-07-01</date><risdate>2024</risdate><volume>31</volume><issue>7</issue><artnum>210</artnum><issn>1022-9760</issn><eissn>1572-8935</eissn><abstract>This study presents the synthesis and characterization of a silver nanocomposite semi-interpenetrating polymer network (semi-IPN) hydrogel using sodium alginate-
g
-polyacrylamide (Ag@Alg-g-PAAm). The silver nanoparticles were synthesized in the presence of sodium alginate and sunlight. The first network was formed thermally with N, N´-Methylenebisacrylamide as a crosslinker, and the second network was created using calcium chloride for networking of sodium alginate. The resulting Ag@Alg-g-PAAm product was characterized using FT-IR, FE-SEM, EDX, TEM, and TG analysis. In addition, in vitro drug release studies were conducted for Epirubicin, an anticancer drug, at pHs 5.4 and 7.4 at 37 ˚C. The release of Epirubicin from Ag@Alg-g-PAAm was higher at pH 5.4 compared to pH 7.4. These findings align with the swelling behavior of Ag@Alg-g-PAAm, where greater swelling occurred at pH 5.4.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10965-024-04020-5</doi><orcidid>https://orcid.org/0000-0001-7331-0059</orcidid></addata></record> |
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| subjects | Calcium chloride Characterization and Evaluation of Materials Chemical synthesis Chemistry Chemistry and Materials Science Hydrogels Industrial Chemistry/Chemical Engineering Interpenetrating networks Methylene bisacrylamide Nanocomposites Original Paper Polyacrylamide Polymer Sciences Polymers Silver Sodium alginate Swelling |
| title | Synthesis of silver nanocomposite semi-interpenetrating polymer network hydrogel based on sodium alginate-g-polyacrylamide for using in Epirubicin anticancer drug release |
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