The association between selenium status and cognitive decline in very old adults: The Newcastle 85+ Study
The trace element selenium is known to protect against oxidative damage which is known to contribute to cognitive impairment with ageing (1,2). The aim of this study was to explore the association between selenium status (serum selenium and selenoprotein P (SELENOP)) and global cognitive performance...
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| Veröffentlicht in: | Proceedings of the Nutrition Society 2024-06, Vol.83 (OCE2), Article E200 |
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| creator | Perri, G. Mathers, J. C Martin-Ruiz, C. Parker, C. Demircan, K. Chillon, T. S. Schomburg, L. Robinson, L. Stevenson, E. J Terrera, G. Sniehotta, F. F Ritchie, C. Adamson, A. Burns, A. Minihane, A.M Shannon, O. Hill, T.R |
| description | The trace element selenium is known to protect against oxidative damage which is known to contribute to cognitive impairment with ageing (1,2). The aim of this study was to explore the association between selenium status (serum selenium and selenoprotein P (SELENOP)) and global cognitive performance at baseline and after 5 years in 85-year-olds living in the Northeast of England. Serum selenium and SELENOP concentrations were measured at baseline by total reflection X-ray fluorescence (TXRF) and enzyme-linked immunosorbent assay (ELISA), respectively, in 757 participants from the Newcastle 85+ study. Global cognitive performance was assessed using the Standardized Mini-Mental State Examination (SMMSE) where scores ≤25 out of 30 indicated cognitive impairment. Logistic regressions explored the associations between selenium status and global cognition at baseline. Linear mixed models explored associations between selenium status and global cognition prospectively after 5 years. Covariates included sex, body mass index, physical activity, high sensitivity C-reactive protein, alcohol intake, self-rated health, medications and smoking status. At baseline, in fully adjusted models, there was no increase in odds of cognitive impairment with serum selenium (OR 1.004, 95% CI 0.993-1.015, p = 0.512) or between SELENOP (OR 1.006, 95% CI 0.881-1.149, p = 0.930). Likewise, over 5 years, in fully adjusted models there was no association between serum selenium and cognitive impairment (β 7.20E-4 ± 5.57E-4, p = 0.197), or between SELENOP and cognitive impairment (β 3.50E-3 ± 6.85E-3, p = 0.610). In this UK cohort of very old adults, serum selenium or SELENOP was not associated with cognitive impairment at baseline and 5 years. This was an unexpected finding despite SELENOP’s key role in the brain and the observed associations in other studies. Further research is needed to explore the effect of selenium on global cognition in very old adults. |
| doi_str_mv | 10.1017/S0029665124004245 |
| format | Article |
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C ; Martin-Ruiz, C. ; Parker, C. ; Demircan, K. ; Chillon, T. S. ; Schomburg, L. ; Robinson, L. ; Stevenson, E. J ; Terrera, G. ; Sniehotta, F. F ; Ritchie, C. ; Adamson, A. ; Burns, A. ; Minihane, A.M ; Shannon, O. ; Hill, T.R</creator><creatorcontrib>Perri, G. ; Mathers, J. C ; Martin-Ruiz, C. ; Parker, C. ; Demircan, K. ; Chillon, T. S. ; Schomburg, L. ; Robinson, L. ; Stevenson, E. J ; Terrera, G. ; Sniehotta, F. F ; Ritchie, C. ; Adamson, A. ; Burns, A. ; Minihane, A.M ; Shannon, O. ; Hill, T.R</creatorcontrib><description>The trace element selenium is known to protect against oxidative damage which is known to contribute to cognitive impairment with ageing (1,2). The aim of this study was to explore the association between selenium status (serum selenium and selenoprotein P (SELENOP)) and global cognitive performance at baseline and after 5 years in 85-year-olds living in the Northeast of England. Serum selenium and SELENOP concentrations were measured at baseline by total reflection X-ray fluorescence (TXRF) and enzyme-linked immunosorbent assay (ELISA), respectively, in 757 participants from the Newcastle 85+ study. Global cognitive performance was assessed using the Standardized Mini-Mental State Examination (SMMSE) where scores ≤25 out of 30 indicated cognitive impairment. Logistic regressions explored the associations between selenium status and global cognition at baseline. Linear mixed models explored associations between selenium status and global cognition prospectively after 5 years. Covariates included sex, body mass index, physical activity, high sensitivity C-reactive protein, alcohol intake, self-rated health, medications and smoking status. At baseline, in fully adjusted models, there was no increase in odds of cognitive impairment with serum selenium (OR 1.004, 95% CI 0.993-1.015, p = 0.512) or between SELENOP (OR 1.006, 95% CI 0.881-1.149, p = 0.930). Likewise, over 5 years, in fully adjusted models there was no association between serum selenium and cognitive impairment (β 7.20E-4 ± 5.57E-4, p = 0.197), or between SELENOP and cognitive impairment (β 3.50E-3 ± 6.85E-3, p = 0.610). In this UK cohort of very old adults, serum selenium or SELENOP was not associated with cognitive impairment at baseline and 5 years. This was an unexpected finding despite SELENOP’s key role in the brain and the observed associations in other studies. Further research is needed to explore the effect of selenium on global cognition in very old adults.</description><identifier>ISSN: 0029-6651</identifier><identifier>EISSN: 1475-2719</identifier><identifier>DOI: 10.1017/S0029665124004245</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adults ; Body mass index ; Body size ; C-reactive protein ; Cognition ; Cognition & reasoning ; Cognitive ability ; Enzyme-linked immunosorbent assay ; Impairment ; Physical activity ; Selenium ; Trace elements ; Trace elements (nutrients) ; X ray reflection ; X-ray fluorescence</subject><ispartof>Proceedings of the Nutrition Society, 2024-06, Vol.83 (OCE2), Article E200</ispartof><rights>The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0029665124004245/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids></links><search><creatorcontrib>Perri, G.</creatorcontrib><creatorcontrib>Mathers, J. C</creatorcontrib><creatorcontrib>Martin-Ruiz, C.</creatorcontrib><creatorcontrib>Parker, C.</creatorcontrib><creatorcontrib>Demircan, K.</creatorcontrib><creatorcontrib>Chillon, T. S.</creatorcontrib><creatorcontrib>Schomburg, L.</creatorcontrib><creatorcontrib>Robinson, L.</creatorcontrib><creatorcontrib>Stevenson, E. J</creatorcontrib><creatorcontrib>Terrera, G.</creatorcontrib><creatorcontrib>Sniehotta, F. F</creatorcontrib><creatorcontrib>Ritchie, C.</creatorcontrib><creatorcontrib>Adamson, A.</creatorcontrib><creatorcontrib>Burns, A.</creatorcontrib><creatorcontrib>Minihane, A.M</creatorcontrib><creatorcontrib>Shannon, O.</creatorcontrib><creatorcontrib>Hill, T.R</creatorcontrib><title>The association between selenium status and cognitive decline in very old adults: The Newcastle 85+ Study</title><title>Proceedings of the Nutrition Society</title><addtitle>Proc. Nutr. Soc</addtitle><description>The trace element selenium is known to protect against oxidative damage which is known to contribute to cognitive impairment with ageing (1,2). The aim of this study was to explore the association between selenium status (serum selenium and selenoprotein P (SELENOP)) and global cognitive performance at baseline and after 5 years in 85-year-olds living in the Northeast of England. Serum selenium and SELENOP concentrations were measured at baseline by total reflection X-ray fluorescence (TXRF) and enzyme-linked immunosorbent assay (ELISA), respectively, in 757 participants from the Newcastle 85+ study. Global cognitive performance was assessed using the Standardized Mini-Mental State Examination (SMMSE) where scores ≤25 out of 30 indicated cognitive impairment. Logistic regressions explored the associations between selenium status and global cognition at baseline. Linear mixed models explored associations between selenium status and global cognition prospectively after 5 years. Covariates included sex, body mass index, physical activity, high sensitivity C-reactive protein, alcohol intake, self-rated health, medications and smoking status. At baseline, in fully adjusted models, there was no increase in odds of cognitive impairment with serum selenium (OR 1.004, 95% CI 0.993-1.015, p = 0.512) or between SELENOP (OR 1.006, 95% CI 0.881-1.149, p = 0.930). Likewise, over 5 years, in fully adjusted models there was no association between serum selenium and cognitive impairment (β 7.20E-4 ± 5.57E-4, p = 0.197), or between SELENOP and cognitive impairment (β 3.50E-3 ± 6.85E-3, p = 0.610). In this UK cohort of very old adults, serum selenium or SELENOP was not associated with cognitive impairment at baseline and 5 years. This was an unexpected finding despite SELENOP’s key role in the brain and the observed associations in other studies. Further research is needed to explore the effect of selenium on global cognition in very old adults.</description><subject>Adults</subject><subject>Body mass index</subject><subject>Body size</subject><subject>C-reactive protein</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Impairment</subject><subject>Physical activity</subject><subject>Selenium</subject><subject>Trace elements</subject><subject>Trace elements (nutrients)</subject><subject>X ray reflection</subject><subject>X-ray fluorescence</subject><issn>0029-6651</issn><issn>1475-2719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLAzEUhYMoWKs_wF3ApYzmPTPupPiCoovW9ZBJ7tSUaaYmmZb-ezu04EJc3cU53zmXg9A1JXeU0Px-RggrlZKUCUIEE_IEjajIZcZyWp6i0SBng36OLmJcEkKVKNQIufkXYB1jZ5xOrvO4hrQF8DhCC971KxyTTn3E2ltsuoV3yW0AWzCt84CdxxsIO9y1Fmvbtyk-4CHxHbZGx9QCLuQtnqXe7i7RWaPbCFfHO0afz0_zyWs2_Xh5mzxOM0OpEJkSdUOVBM6ASQMFZ6Xc_82ZtpY0RoCStSJGScaAG1rmecNJU4tSElvWBeFjdHPIXYfuu4eYqmXXB7-vrDjJJaFcFmLvogeXCV2MAZpqHdxKh11FSTUsWv1ZdM_wI6NXdXB2Ab_R_1M_bZB28w</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Perri, G.</creator><creator>Mathers, J. 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S. ; Schomburg, L. ; Robinson, L. ; Stevenson, E. J ; Terrera, G. ; Sniehotta, F. 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C</au><au>Martin-Ruiz, C.</au><au>Parker, C.</au><au>Demircan, K.</au><au>Chillon, T. S.</au><au>Schomburg, L.</au><au>Robinson, L.</au><au>Stevenson, E. J</au><au>Terrera, G.</au><au>Sniehotta, F. F</au><au>Ritchie, C.</au><au>Adamson, A.</au><au>Burns, A.</au><au>Minihane, A.M</au><au>Shannon, O.</au><au>Hill, T.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between selenium status and cognitive decline in very old adults: The Newcastle 85+ Study</atitle><jtitle>Proceedings of the Nutrition Society</jtitle><addtitle>Proc. Nutr. Soc</addtitle><date>2024-06</date><risdate>2024</risdate><volume>83</volume><issue>OCE2</issue><artnum>E200</artnum><issn>0029-6651</issn><eissn>1475-2719</eissn><abstract>The trace element selenium is known to protect against oxidative damage which is known to contribute to cognitive impairment with ageing (1,2). The aim of this study was to explore the association between selenium status (serum selenium and selenoprotein P (SELENOP)) and global cognitive performance at baseline and after 5 years in 85-year-olds living in the Northeast of England. Serum selenium and SELENOP concentrations were measured at baseline by total reflection X-ray fluorescence (TXRF) and enzyme-linked immunosorbent assay (ELISA), respectively, in 757 participants from the Newcastle 85+ study. Global cognitive performance was assessed using the Standardized Mini-Mental State Examination (SMMSE) where scores ≤25 out of 30 indicated cognitive impairment. Logistic regressions explored the associations between selenium status and global cognition at baseline. Linear mixed models explored associations between selenium status and global cognition prospectively after 5 years. Covariates included sex, body mass index, physical activity, high sensitivity C-reactive protein, alcohol intake, self-rated health, medications and smoking status. At baseline, in fully adjusted models, there was no increase in odds of cognitive impairment with serum selenium (OR 1.004, 95% CI 0.993-1.015, p = 0.512) or between SELENOP (OR 1.006, 95% CI 0.881-1.149, p = 0.930). Likewise, over 5 years, in fully adjusted models there was no association between serum selenium and cognitive impairment (β 7.20E-4 ± 5.57E-4, p = 0.197), or between SELENOP and cognitive impairment (β 3.50E-3 ± 6.85E-3, p = 0.610). In this UK cohort of very old adults, serum selenium or SELENOP was not associated with cognitive impairment at baseline and 5 years. This was an unexpected finding despite SELENOP’s key role in the brain and the observed associations in other studies. Further research is needed to explore the effect of selenium on global cognition in very old adults.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><doi>10.1017/S0029665124004245</doi><tpages>1</tpages></addata></record> |
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| subjects | Adults Body mass index Body size C-reactive protein Cognition Cognition & reasoning Cognitive ability Enzyme-linked immunosorbent assay Impairment Physical activity Selenium Trace elements Trace elements (nutrients) X ray reflection X-ray fluorescence |
| title | The association between selenium status and cognitive decline in very old adults: The Newcastle 85+ Study |
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