Novel findings on the bioactivities of black ginger of Vietnam and optimization of its extraction using response surface methodology
The present study aimed to evaluate the antioxidant activity and antithrombotic effect of the n -hexane extract from rhizomes Distichochlamys citrea (DC-R), an endemic ginger species of Vietnam. Results showed that DC-R expressed a more potent antioxidative effect against ABTS than DPPH radical ( p...
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| Veröffentlicht in: | Chemical papers 2024-06, Vol.78 (9), p.5191-5207 |
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| creator | Nguyen, Thi Van Anh Nguyen, Thanh Hang Nguyen, Thi Kieu Oanh Nguyen, Phuong Nhung Le, Hong Luyen |
| description | The present study aimed to evaluate the antioxidant activity and antithrombotic effect of the
n
-hexane extract from rhizomes
Distichochlamys citrea
(DC-R), an endemic ginger species of Vietnam. Results showed that DC-R expressed a more potent antioxidative effect against ABTS than DPPH radical (
p
0.95,
p
|
| doi_str_mv | 10.1007/s11696-024-03458-7 |
| format | Article |
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n
-hexane extract from rhizomes
Distichochlamys citrea
(DC-R), an endemic ginger species of Vietnam. Results showed that DC-R expressed a more potent antioxidative effect against ABTS than DPPH radical (
p
< 0.05). DC-R contained a total phenolic content of 3.41 g GAE/100 g and a total flavonoid content of 18.33 g QE/100 g of the dried extract. At concentrations of 1, 2 and 4 mg/mL, DC-R reduced the percentage of platelet aggregation triggered by ADP, collagen and ristocetin in a dose-dependent manner (Pearson’s correlation,
r
> 0.95,
p
< 0.05). DC-R also exhibited anticoagulant activity by significantly prolonging the activated prothrombin time (APTT) at all concentrations tested (
p
< 0.05 compared to DMSO 0.1%). GC–MS revealed 41 volatile components in DC-R, in which several compounds were firmly bound to receptors COX-1 and P2Y12 of the platelet aggregation and factors X and II of the blood coagulation cascades. Using response surface methodology with central composition design, the extraction yield of DC-R reached the highest value (1.011 ± 0.008%) at optimized conditions: liquid/ solid ratio 13.5 mL/g, ultrasonic power level 80%, extraction time 30 min, and extraction temperature 34 °C.</description><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>EISSN: 2585-7290</identifier><identifier>DOI: 10.1007/s11696-024-03458-7</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biochemistry ; Biotechnology ; Blood coagulation ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Ginger ; Hexanes ; Industrial Chemistry/Chemical Engineering ; Materials Science ; Medicinal Chemistry ; Original Paper ; Platelets ; Prothrombin ; Response surface methodology</subject><ispartof>Chemical papers, 2024-06, Vol.78 (9), p.5191-5207</ispartof><rights>The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-cd62e5961f07a2af7538e78531a383163de4a17156727db8d2dfe3c851c95ef83</cites><orcidid>0000-0003-3417-5928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-024-03458-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-024-03458-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids></links><search><creatorcontrib>Nguyen, Thi Van Anh</creatorcontrib><creatorcontrib>Nguyen, Thanh Hang</creatorcontrib><creatorcontrib>Nguyen, Thi Kieu Oanh</creatorcontrib><creatorcontrib>Nguyen, Phuong Nhung</creatorcontrib><creatorcontrib>Le, Hong Luyen</creatorcontrib><title>Novel findings on the bioactivities of black ginger of Vietnam and optimization of its extraction using response surface methodology</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>The present study aimed to evaluate the antioxidant activity and antithrombotic effect of the
n
-hexane extract from rhizomes
Distichochlamys citrea
(DC-R), an endemic ginger species of Vietnam. Results showed that DC-R expressed a more potent antioxidative effect against ABTS than DPPH radical (
p
< 0.05). DC-R contained a total phenolic content of 3.41 g GAE/100 g and a total flavonoid content of 18.33 g QE/100 g of the dried extract. At concentrations of 1, 2 and 4 mg/mL, DC-R reduced the percentage of platelet aggregation triggered by ADP, collagen and ristocetin in a dose-dependent manner (Pearson’s correlation,
r
> 0.95,
p
< 0.05). DC-R also exhibited anticoagulant activity by significantly prolonging the activated prothrombin time (APTT) at all concentrations tested (
p
< 0.05 compared to DMSO 0.1%). GC–MS revealed 41 volatile components in DC-R, in which several compounds were firmly bound to receptors COX-1 and P2Y12 of the platelet aggregation and factors X and II of the blood coagulation cascades. Using response surface methodology with central composition design, the extraction yield of DC-R reached the highest value (1.011 ± 0.008%) at optimized conditions: liquid/ solid ratio 13.5 mL/g, ultrasonic power level 80%, extraction time 30 min, and extraction temperature 34 °C.</description><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Blood coagulation</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Ginger</subject><subject>Hexanes</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Original Paper</subject><subject>Platelets</subject><subject>Prothrombin</subject><subject>Response surface methodology</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEURYMoWKt_wFXA9Wg-JsnMUopfUHSjbkM689KmTic1SYt17Q83YwV3rh7v5Z4bOAidU3JJCVFXkVJZy4KwsiC8FFWhDtCIci6LmihxiEaES1lILtgxOolxSUhZEkFG6OvRb6HD1vWt6-cR-x6nBeCZ86ZJbuuSg3y0eNaZ5g3PcwbCsL86SL1ZYdO32K-TW7lPk1ym85tLEcNHCkNDvmxipnCAuPZ9BBw3wZoG8ArSwre-8_PdKTqypotw9jvH6OX25nlyX0yf7h4m19OiYYqkomklA1FLaokyzFgleAWqEpwaXnEqeQuloYoKqZhqZ1XLWgu8qQRtagG24mN0se9dB_--gZj00m9Cn7_UnChaV4oRnlNsn2qCjzGA1evgVibsNCV6sK33tnW2rX9sa5UhvodiDg-S_qr_ob4BMwaE8g</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Nguyen, Thi Van Anh</creator><creator>Nguyen, Thanh Hang</creator><creator>Nguyen, Thi Kieu Oanh</creator><creator>Nguyen, Phuong Nhung</creator><creator>Le, Hong Luyen</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-3417-5928</orcidid></search><sort><creationdate>20240601</creationdate><title>Novel findings on the bioactivities of black ginger of Vietnam and optimization of its extraction using response surface methodology</title><author>Nguyen, Thi Van Anh ; Nguyen, Thanh Hang ; Nguyen, Thi Kieu Oanh ; Nguyen, Phuong Nhung ; Le, Hong Luyen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-cd62e5961f07a2af7538e78531a383163de4a17156727db8d2dfe3c851c95ef83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Blood coagulation</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Ginger</topic><topic>Hexanes</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Original Paper</topic><topic>Platelets</topic><topic>Prothrombin</topic><topic>Response surface methodology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Thi Van Anh</creatorcontrib><creatorcontrib>Nguyen, Thanh Hang</creatorcontrib><creatorcontrib>Nguyen, Thi Kieu Oanh</creatorcontrib><creatorcontrib>Nguyen, Phuong Nhung</creatorcontrib><creatorcontrib>Le, Hong Luyen</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Thi Van Anh</au><au>Nguyen, Thanh Hang</au><au>Nguyen, Thi Kieu Oanh</au><au>Nguyen, Phuong Nhung</au><au>Le, Hong Luyen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel findings on the bioactivities of black ginger of Vietnam and optimization of its extraction using response surface methodology</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2024-06-01</date><risdate>2024</risdate><volume>78</volume><issue>9</issue><spage>5191</spage><epage>5207</epage><pages>5191-5207</pages><issn>0366-6352</issn><eissn>1336-9075</eissn><eissn>2585-7290</eissn><abstract>The present study aimed to evaluate the antioxidant activity and antithrombotic effect of the
n
-hexane extract from rhizomes
Distichochlamys citrea
(DC-R), an endemic ginger species of Vietnam. Results showed that DC-R expressed a more potent antioxidative effect against ABTS than DPPH radical (
p
< 0.05). DC-R contained a total phenolic content of 3.41 g GAE/100 g and a total flavonoid content of 18.33 g QE/100 g of the dried extract. At concentrations of 1, 2 and 4 mg/mL, DC-R reduced the percentage of platelet aggregation triggered by ADP, collagen and ristocetin in a dose-dependent manner (Pearson’s correlation,
r
> 0.95,
p
< 0.05). DC-R also exhibited anticoagulant activity by significantly prolonging the activated prothrombin time (APTT) at all concentrations tested (
p
< 0.05 compared to DMSO 0.1%). GC–MS revealed 41 volatile components in DC-R, in which several compounds were firmly bound to receptors COX-1 and P2Y12 of the platelet aggregation and factors X and II of the blood coagulation cascades. Using response surface methodology with central composition design, the extraction yield of DC-R reached the highest value (1.011 ± 0.008%) at optimized conditions: liquid/ solid ratio 13.5 mL/g, ultrasonic power level 80%, extraction time 30 min, and extraction temperature 34 °C.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11696-024-03458-7</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-3417-5928</orcidid></addata></record> |
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| subjects | Biochemistry Biotechnology Blood coagulation Chemistry Chemistry and Materials Science Chemistry/Food Science Ginger Hexanes Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry Original Paper Platelets Prothrombin Response surface methodology |
| title | Novel findings on the bioactivities of black ginger of Vietnam and optimization of its extraction using response surface methodology |
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