Spectrofluorimetric determination of Alogliptin benzoate through condensation with ninhydrin and phenylacetaldehyde: application to dosage form and rat plasma

Alogliptin benzoate (ALG) is a dipeptidyl peptidase-4 inhibitor used to treat type 2 diabetes mellitus. In this study, a spectrofluorimetric method was developed for the derivatization of ALG to develop a fluorescent derivative. The derivatization reaction was carried out by reacting ALG with ninhyd...

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Veröffentlicht in:	Chemical papers 2024-06, Vol.78 (8), p.5049-5060
Hauptverfasser:	El-Gizawy, Samia M., Atia, Noha N., Rushdy, Doaa H., Ali, Marwa F. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoates Biochemistry Biotechnology Calibration Chemistry Chemistry and Materials Science Chemistry/Food Science Condensates Correlation coefficients Diabetes mellitus Dosage Fluorescence Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry Ninhydrin Original Paper Phenylacetaldehyde Reaction products Spectrofluorimetry
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