Relationship Between the Volume of Benzyl Substituent in Isatin-3-acylhydrazones and Their Antimicrobial Activity

Relationship Between the Volume of Benzyl Substituent in Isatin-3-acylhydrazones and Their Antimicrobial Activity

Water-soluble ammonium salts were prepared by the reaction of new sterically hindered isatin derivatives with analogues of Girard's reagents. The resulting isatin-3-hydrazones exhibit high antimicrobial and antiaggregation activity with low hemotoxicity. The dependence of physiological activity...

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Veröffentlicht in:Russian journal of general chemistry 2024-04, Vol.94 (4), p.878-883
Hauptverfasser: Bogdanov, A. V., Voloshina, A. D., Khamatgalimov, A. R., Rakhmatullin, R. R., Samorodov, A. V., Valiullina, Z. A., Mironov, V. F.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydrazones
Reagents
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Zusammenfassung:Water-soluble ammonium salts were prepared by the reaction of new sterically hindered isatin derivatives with analogues of Girard's reagents. The resulting isatin-3-hydrazones exhibit high antimicrobial and antiaggregation activity with low hemotoxicity. The dependence of physiological activity on the volume of the benzyl substituent was established.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363224040157