Association of insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene (ACE) with Parkinson’s disease and factors risk in eastern Algeria: case–control study
Background This study aimed to explore the relationship between Parkinson’s disease and insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme gene ( ACE ) and to highlight the related risk factors within Eastern Algerian population. A total of 262 individuals were recruited, inc...
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| Veröffentlicht in: | Egyptian Journal of Medical Human Genetics 2024-06, Vol.25 (1), p.66-6, Article 66 |
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| container_title | Egyptian Journal of Medical Human Genetics |
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| creator | Meroua, Horchi-Mekkaoui Rayene, Achou Brahim, Djoudi Rania, Laouar Razika, Gharzouli Naima, Taghane Noureddine, Abadi Dalila, Satta |
| description | Background
This study aimed to explore the relationship between Parkinson’s disease and insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme gene (
ACE
) and to highlight the related risk factors within Eastern Algerian population. A total of 262 individuals were recruited, including 100 PD patients and 162 controls. Polymerase chain reaction technique was employed to determine the
ACE
polymorphism genotype of each participant. Logistic regression analysis was conducted to examine factors potentially contributing to Parkinson’s disease.
Results
The mean age of onset of Parkinson’s disease in the patient group was 56.18
±
12.99
. The results revealed that the D allele of the angiotensin-converting enzyme gene and the DD genotype were most prevalent in both patients and controls. However, there were no significant differences in the genotype and allele frequencies of the I/D polymorphism of the angiotensin-converting enzyme gene between patients and healthy subjects. Cardiovascular disease, diabetes and profession were identified as potential risk factors for Parkinson’s disease.
Conclusion
The obtained data indicated no correlation between the angiotensin-converting enzyme I/D gene polymorphism and Parkinson’s disease in our research cohort. Multiple logistic regression analysis revealed that cardiovascular disease, diabetes and profession were possible risk factors for Parkinson’s disease. |
| doi_str_mv | 10.1186/s43042-024-00536-z |
| format | Article |
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This study aimed to explore the relationship between Parkinson’s disease and insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme gene (
ACE
) and to highlight the related risk factors within Eastern Algerian population. A total of 262 individuals were recruited, including 100 PD patients and 162 controls. Polymerase chain reaction technique was employed to determine the
ACE
polymorphism genotype of each participant. Logistic regression analysis was conducted to examine factors potentially contributing to Parkinson’s disease.
Results
The mean age of onset of Parkinson’s disease in the patient group was 56.18
±
12.99
. The results revealed that the D allele of the angiotensin-converting enzyme gene and the DD genotype were most prevalent in both patients and controls. However, there were no significant differences in the genotype and allele frequencies of the I/D polymorphism of the angiotensin-converting enzyme gene between patients and healthy subjects. Cardiovascular disease, diabetes and profession were identified as potential risk factors for Parkinson’s disease.
Conclusion
The obtained data indicated no correlation between the angiotensin-converting enzyme I/D gene polymorphism and Parkinson’s disease in our research cohort. Multiple logistic regression analysis revealed that cardiovascular disease, diabetes and profession were possible risk factors for Parkinson’s disease.</description><identifier>ISSN: 2090-2441</identifier><identifier>ISSN: 1110-8630</identifier><identifier>EISSN: 2090-2441</identifier><identifier>DOI: 10.1186/s43042-024-00536-z</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age groups ; Alleles ; Angiotensin ; Angiotensin-converting enzyme gene ; Cardiovascular diseases ; Chi-square test ; Confidence intervals ; D gene ; Deoxyribonucleic acid ; Diabetes ; Diabetes mellitus ; DNA ; Enzymes ; Gene deletion ; Gene frequency ; Gene polymorphism ; Genes ; Genetic testing ; Genotype & phenotype ; Hypertension ; Insertion ; Insertion/deletion polymorphism ; Medicine ; Medicine & Public Health ; Movement disorders ; Neurodegenerative diseases ; Parkinson's disease ; Patients ; Peptidyl-dipeptidase A ; Polymorphism ; Regression analysis ; Risk factors</subject><ispartof>Egyptian Journal of Medical Human Genetics, 2024-06, Vol.25 (1), p.66-6, Article 66</ispartof><rights>The Author(s) 2024</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c310t-3a0f048e480917ba27fbcec46696a16ddeddb03adf9bac09bcd7ecb25138a9293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Meroua, Horchi-Mekkaoui</creatorcontrib><creatorcontrib>Rayene, Achou</creatorcontrib><creatorcontrib>Brahim, Djoudi</creatorcontrib><creatorcontrib>Rania, Laouar</creatorcontrib><creatorcontrib>Razika, Gharzouli</creatorcontrib><creatorcontrib>Naima, Taghane</creatorcontrib><creatorcontrib>Noureddine, Abadi</creatorcontrib><creatorcontrib>Dalila, Satta</creatorcontrib><title>Association of insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene (ACE) with Parkinson’s disease and factors risk in eastern Algeria: case–control study</title><title>Egyptian Journal of Medical Human Genetics</title><addtitle>Egypt J Med Hum Genet</addtitle><description>Background
This study aimed to explore the relationship between Parkinson’s disease and insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme gene (
ACE
) and to highlight the related risk factors within Eastern Algerian population. A total of 262 individuals were recruited, including 100 PD patients and 162 controls. Polymerase chain reaction technique was employed to determine the
ACE
polymorphism genotype of each participant. Logistic regression analysis was conducted to examine factors potentially contributing to Parkinson’s disease.
Results
The mean age of onset of Parkinson’s disease in the patient group was 56.18
±
12.99
. The results revealed that the D allele of the angiotensin-converting enzyme gene and the DD genotype were most prevalent in both patients and controls. However, there were no significant differences in the genotype and allele frequencies of the I/D polymorphism of the angiotensin-converting enzyme gene between patients and healthy subjects. Cardiovascular disease, diabetes and profession were identified as potential risk factors for Parkinson’s disease.
Conclusion
The obtained data indicated no correlation between the angiotensin-converting enzyme I/D gene polymorphism and Parkinson’s disease in our research cohort. Multiple logistic regression analysis revealed that cardiovascular disease, diabetes and profession were possible risk factors for Parkinson’s disease.</description><subject>Age groups</subject><subject>Alleles</subject><subject>Angiotensin</subject><subject>Angiotensin-converting enzyme gene</subject><subject>Cardiovascular diseases</subject><subject>Chi-square test</subject><subject>Confidence intervals</subject><subject>D gene</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Gene deletion</subject><subject>Gene frequency</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic testing</subject><subject>Genotype & phenotype</subject><subject>Hypertension</subject><subject>Insertion</subject><subject>Insertion/deletion polymorphism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Peptidyl-dipeptidase A</subject><subject>Polymorphism</subject><subject>Regression analysis</subject><subject>Risk factors</subject><issn>2090-2441</issn><issn>1110-8630</issn><issn>2090-2441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kc1uEzEUhUcIJErhBVhZYtMuhvgvnjG7KBSIVAkWsLY89vXU6cQO9qQoWfUdWPEgvFCfBCeDgBUr29fnfPfap6peEvyakFbMMmeY0xpTXmM8Z6I-PKrOKJa4ppyTx__sn1bPcl5jLOas4WfVz0XO0Xg9-hhQdMiHDOl4mFkY4FS9WM3eXqJtHPabmLY3Pm-OQh16H0cI2YfaxHB3dIUeQTjsN4B6CIAuFsurS_TNjzfok063BR3Dw_2PjKzPoDMUhkVOmzGmjJLPt6U7KhcjpIAWQw_J6zfIFOXD_ffSY0xxQHnc2f3z6onTQ4YXv9fz6su7q8_LD_X1x_er5eK6NozgsWYaO8xb4C2WpOk0bVxnwHAhpNBEWAvWdphp62SnDZadsQ2Yjs4Ja7Wkkp1Xq4lro16rbfIbnfYqaq9OhZh6pcu7zQBKSMocB2qoYJwLrolmGAQB0biWm66wXk2sbYpfd5BHtY67FMr4imEhmZwT3hYVnVQmxZwTuD9dCVbHqNUUtSpRq1PU6lBMbDLlIg7l3_6i_-P6BS66sko</recordid><startdate>20240618</startdate><enddate>20240618</enddate><creator>Meroua, Horchi-Mekkaoui</creator><creator>Rayene, Achou</creator><creator>Brahim, Djoudi</creator><creator>Rania, Laouar</creator><creator>Razika, Gharzouli</creator><creator>Naima, Taghane</creator><creator>Noureddine, Abadi</creator><creator>Dalila, Satta</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20240618</creationdate><title>Association of insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene (ACE) with Parkinson’s disease and factors risk in eastern Algeria: case–control study</title><author>Meroua, Horchi-Mekkaoui ; Rayene, Achou ; Brahim, Djoudi ; Rania, Laouar ; Razika, Gharzouli ; Naima, Taghane ; Noureddine, Abadi ; Dalila, Satta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-3a0f048e480917ba27fbcec46696a16ddeddb03adf9bac09bcd7ecb25138a9293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age groups</topic><topic>Alleles</topic><topic>Angiotensin</topic><topic>Angiotensin-converting enzyme gene</topic><topic>Cardiovascular diseases</topic><topic>Chi-square test</topic><topic>Confidence intervals</topic><topic>D gene</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Gene deletion</topic><topic>Gene frequency</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic testing</topic><topic>Genotype & phenotype</topic><topic>Hypertension</topic><topic>Insertion</topic><topic>Insertion/deletion polymorphism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Peptidyl-dipeptidase A</topic><topic>Polymorphism</topic><topic>Regression analysis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meroua, Horchi-Mekkaoui</creatorcontrib><creatorcontrib>Rayene, Achou</creatorcontrib><creatorcontrib>Brahim, Djoudi</creatorcontrib><creatorcontrib>Rania, Laouar</creatorcontrib><creatorcontrib>Razika, Gharzouli</creatorcontrib><creatorcontrib>Naima, Taghane</creatorcontrib><creatorcontrib>Noureddine, Abadi</creatorcontrib><creatorcontrib>Dalila, Satta</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Medical Human Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meroua, Horchi-Mekkaoui</au><au>Rayene, Achou</au><au>Brahim, Djoudi</au><au>Rania, Laouar</au><au>Razika, Gharzouli</au><au>Naima, Taghane</au><au>Noureddine, Abadi</au><au>Dalila, Satta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene (ACE) with Parkinson’s disease and factors risk in eastern Algeria: case–control study</atitle><jtitle>Egyptian Journal of Medical Human Genetics</jtitle><stitle>Egypt J Med Hum Genet</stitle><date>2024-06-18</date><risdate>2024</risdate><volume>25</volume><issue>1</issue><spage>66</spage><epage>6</epage><pages>66-6</pages><artnum>66</artnum><issn>2090-2441</issn><issn>1110-8630</issn><eissn>2090-2441</eissn><abstract>Background
This study aimed to explore the relationship between Parkinson’s disease and insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme gene (
ACE
) and to highlight the related risk factors within Eastern Algerian population. A total of 262 individuals were recruited, including 100 PD patients and 162 controls. Polymerase chain reaction technique was employed to determine the
ACE
polymorphism genotype of each participant. Logistic regression analysis was conducted to examine factors potentially contributing to Parkinson’s disease.
Results
The mean age of onset of Parkinson’s disease in the patient group was 56.18
±
12.99
. The results revealed that the D allele of the angiotensin-converting enzyme gene and the DD genotype were most prevalent in both patients and controls. However, there were no significant differences in the genotype and allele frequencies of the I/D polymorphism of the angiotensin-converting enzyme gene between patients and healthy subjects. Cardiovascular disease, diabetes and profession were identified as potential risk factors for Parkinson’s disease.
Conclusion
The obtained data indicated no correlation between the angiotensin-converting enzyme I/D gene polymorphism and Parkinson’s disease in our research cohort. Multiple logistic regression analysis revealed that cardiovascular disease, diabetes and profession were possible risk factors for Parkinson’s disease.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43042-024-00536-z</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Alleles Angiotensin Angiotensin-converting enzyme gene Cardiovascular diseases Chi-square test Confidence intervals D gene Deoxyribonucleic acid Diabetes Diabetes mellitus DNA Enzymes Gene deletion Gene frequency Gene polymorphism Genes Genetic testing Genotype & phenotype Hypertension Insertion Insertion/deletion polymorphism Medicine Medicine & Public Health Movement disorders Neurodegenerative diseases Parkinson's disease Patients Peptidyl-dipeptidase A Polymorphism Regression analysis Risk factors |
| title | Association of insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene (ACE) with Parkinson’s disease and factors risk in eastern Algeria: case–control study |
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