Synthesis and Evaluation of Chalcone Derivatives as Prospective Anti-Inflammatory Compounds
In order to discover novel anti-inflammatory agents, a series of compounds obtained by appending chalcone moieties on dehydroepiandrosterone were designed and synthesized. All compounds were screened for their anti-inflammatory activity by using an ear edema model. Most of the synthesized compounds...
Gespeichert in:
| Veröffentlicht in: | Chemistry of natural compounds 2024-05, Vol.60 (3), p.419-422 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 422 |
|---|---|
| container_issue | 3 |
| container_start_page | 419 |
| container_title | Chemistry of natural compounds |
| container_volume | 60 |
| creator | Bai, Xueqian Liu, Zhe Sheng, Yue Liu, Fuyun Zhang, Tianyi |
| description | In order to discover novel anti-inflammatory agents, a series of compounds obtained by appending chalcone moieties on dehydroepiandrosterone were designed and synthesized. All compounds were screened for their anti-inflammatory activity by using an ear edema model. Most of the synthesized compounds showed potent anti-inflammatory activity at 100 mg/kg with inhibition rates ranging from 27.94% to 56.83%. It is noteworthy that compound
4e
exhibited the most pronounced anti-inflammatory activity of all the compounds with an activity of 56.83%, which was higher than that of celecoxib (47.14%). |
| doi_str_mv | 10.1007/s10600-024-04341-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3065609452</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153660467</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-3a19a7bb94d6fd84ec380255f546e2adb5cbed9ce5ec974bbdd4e563753b3fa3</originalsourceid><addsrcrecordid>eNp9kEFr3DAQhUVpoNskf6AnQy-9KBl5JNk-hk3aBAItZG85CFkedx1saSvZC_vvo-0WCjnkNLzhe4-Zx9gXAVcCoLpOAjQAh1JykCgFxw9sJVSFvMa6_shWANBwFAif2OeUXrKsta5X7Pnp4OctpSEV1nfF3d6Oi52H4IvQF-utHV3wVNxSHPZ5vaeMpeJXDGlH7qiLGz8P_MH3o50mO4d4KNZh2oXFd-mCnfV2THT5b56zzfe7zfqeP_788bC-eeQOAWeOVjS2attGdrrvakkOayiV6pXUVNquVa6lrnGkyDWVbNuuk6Q0Vgpb7C2es2-n2F0MfxZKs5mG5GgcraewJINCodYgdZXRr2_Ql7BEn48zCFppaKQqM1WeKJf_TJF6s4vDZOPBCDDHus2pbpPrNn_rNphNeDKlDPvfFP9Hv-N6BUzXg-0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3065609452</pqid></control><display><type>article</type><title>Synthesis and Evaluation of Chalcone Derivatives as Prospective Anti-Inflammatory Compounds</title><source>SpringerLink Journals</source><creator>Bai, Xueqian ; Liu, Zhe ; Sheng, Yue ; Liu, Fuyun ; Zhang, Tianyi</creator><creatorcontrib>Bai, Xueqian ; Liu, Zhe ; Sheng, Yue ; Liu, Fuyun ; Zhang, Tianyi</creatorcontrib><description>In order to discover novel anti-inflammatory agents, a series of compounds obtained by appending chalcone moieties on dehydroepiandrosterone were designed and synthesized. All compounds were screened for their anti-inflammatory activity by using an ear edema model. Most of the synthesized compounds showed potent anti-inflammatory activity at 100 mg/kg with inhibition rates ranging from 27.94% to 56.83%. It is noteworthy that compound
4e
exhibited the most pronounced anti-inflammatory activity of all the compounds with an activity of 56.83%, which was higher than that of celecoxib (47.14%).</description><identifier>ISSN: 0009-3130</identifier><identifier>EISSN: 1573-8388</identifier><identifier>DOI: 10.1007/s10600-024-04341-3</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>anti-inflammatory activity ; chalcone ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; ears ; Edema ; Organic Chemistry ; Plant Sciences ; prasterone ; Synthesis</subject><ispartof>Chemistry of natural compounds, 2024-05, Vol.60 (3), p.419-422</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-3a19a7bb94d6fd84ec380255f546e2adb5cbed9ce5ec974bbdd4e563753b3fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10600-024-04341-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10600-024-04341-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Bai, Xueqian</creatorcontrib><creatorcontrib>Liu, Zhe</creatorcontrib><creatorcontrib>Sheng, Yue</creatorcontrib><creatorcontrib>Liu, Fuyun</creatorcontrib><creatorcontrib>Zhang, Tianyi</creatorcontrib><title>Synthesis and Evaluation of Chalcone Derivatives as Prospective Anti-Inflammatory Compounds</title><title>Chemistry of natural compounds</title><addtitle>Chem Nat Compd</addtitle><description>In order to discover novel anti-inflammatory agents, a series of compounds obtained by appending chalcone moieties on dehydroepiandrosterone were designed and synthesized. All compounds were screened for their anti-inflammatory activity by using an ear edema model. Most of the synthesized compounds showed potent anti-inflammatory activity at 100 mg/kg with inhibition rates ranging from 27.94% to 56.83%. It is noteworthy that compound
4e
exhibited the most pronounced anti-inflammatory activity of all the compounds with an activity of 56.83%, which was higher than that of celecoxib (47.14%).</description><subject>anti-inflammatory activity</subject><subject>chalcone</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>ears</subject><subject>Edema</subject><subject>Organic Chemistry</subject><subject>Plant Sciences</subject><subject>prasterone</subject><subject>Synthesis</subject><issn>0009-3130</issn><issn>1573-8388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEFr3DAQhUVpoNskf6AnQy-9KBl5JNk-hk3aBAItZG85CFkedx1saSvZC_vvo-0WCjnkNLzhe4-Zx9gXAVcCoLpOAjQAh1JykCgFxw9sJVSFvMa6_shWANBwFAif2OeUXrKsta5X7Pnp4OctpSEV1nfF3d6Oi52H4IvQF-utHV3wVNxSHPZ5vaeMpeJXDGlH7qiLGz8P_MH3o50mO4d4KNZh2oXFd-mCnfV2THT5b56zzfe7zfqeP_788bC-eeQOAWeOVjS2attGdrrvakkOayiV6pXUVNquVa6lrnGkyDWVbNuuk6Q0Vgpb7C2es2-n2F0MfxZKs5mG5GgcraewJINCodYgdZXRr2_Ql7BEn48zCFppaKQqM1WeKJf_TJF6s4vDZOPBCDDHus2pbpPrNn_rNphNeDKlDPvfFP9Hv-N6BUzXg-0</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Bai, Xueqian</creator><creator>Liu, Zhe</creator><creator>Sheng, Yue</creator><creator>Liu, Fuyun</creator><creator>Zhang, Tianyi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20240501</creationdate><title>Synthesis and Evaluation of Chalcone Derivatives as Prospective Anti-Inflammatory Compounds</title><author>Bai, Xueqian ; Liu, Zhe ; Sheng, Yue ; Liu, Fuyun ; Zhang, Tianyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-3a19a7bb94d6fd84ec380255f546e2adb5cbed9ce5ec974bbdd4e563753b3fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>anti-inflammatory activity</topic><topic>chalcone</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>ears</topic><topic>Edema</topic><topic>Organic Chemistry</topic><topic>Plant Sciences</topic><topic>prasterone</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Xueqian</creatorcontrib><creatorcontrib>Liu, Zhe</creatorcontrib><creatorcontrib>Sheng, Yue</creatorcontrib><creatorcontrib>Liu, Fuyun</creatorcontrib><creatorcontrib>Zhang, Tianyi</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Chemistry of natural compounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Xueqian</au><au>Liu, Zhe</au><au>Sheng, Yue</au><au>Liu, Fuyun</au><au>Zhang, Tianyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Evaluation of Chalcone Derivatives as Prospective Anti-Inflammatory Compounds</atitle><jtitle>Chemistry of natural compounds</jtitle><stitle>Chem Nat Compd</stitle><date>2024-05-01</date><risdate>2024</risdate><volume>60</volume><issue>3</issue><spage>419</spage><epage>422</epage><pages>419-422</pages><issn>0009-3130</issn><eissn>1573-8388</eissn><abstract>In order to discover novel anti-inflammatory agents, a series of compounds obtained by appending chalcone moieties on dehydroepiandrosterone were designed and synthesized. All compounds were screened for their anti-inflammatory activity by using an ear edema model. Most of the synthesized compounds showed potent anti-inflammatory activity at 100 mg/kg with inhibition rates ranging from 27.94% to 56.83%. It is noteworthy that compound
4e
exhibited the most pronounced anti-inflammatory activity of all the compounds with an activity of 56.83%, which was higher than that of celecoxib (47.14%).</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10600-024-04341-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-3130 |
| ispartof | Chemistry of natural compounds, 2024-05, Vol.60 (3), p.419-422 |
| issn | 0009-3130 1573-8388 |
| language | eng |
| recordid | cdi_proquest_journals_3065609452 |
| source | SpringerLink Journals |
| subjects | anti-inflammatory activity chalcone Chemistry Chemistry and Materials Science Chemistry/Food Science ears Edema Organic Chemistry Plant Sciences prasterone Synthesis |
| title | Synthesis and Evaluation of Chalcone Derivatives as Prospective Anti-Inflammatory Compounds |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T05%3A00%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20Evaluation%20of%20Chalcone%20Derivatives%20as%20Prospective%20Anti-Inflammatory%20Compounds&rft.jtitle=Chemistry%20of%20natural%20compounds&rft.au=Bai,%20Xueqian&rft.date=2024-05-01&rft.volume=60&rft.issue=3&rft.spage=419&rft.epage=422&rft.pages=419-422&rft.issn=0009-3130&rft.eissn=1573-8388&rft_id=info:doi/10.1007/s10600-024-04341-3&rft_dat=%3Cproquest_cross%3E3153660467%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3065609452&rft_id=info:pmid/&rfr_iscdi=true |