Antibody complementarity-determining region design using AlphaFold2 and DDG predictor

The constraints imposed by natural antibody affinity maturation often culminate in antibodies with suboptimal binding affinities, thereby limiting their therapeutic efficacy. As such, the augmentation of antibody binding affinity is pivotal for the advancement of efficacious antibody-based therapies...

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Veröffentlicht in:	The Journal of supercomputing 2024, Vol.80 (9), p.11989-12002
Hauptverfasser:	Ueki, Takafumi, Ohue, Masahito
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Antibodies Antigens Binding Combinatorial analysis Compilers Computer Science Design optimization Interpreters Processor Architectures Programming Languages
Online-Zugang:	Volltext
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