Reduction in variability of dopamine transporter measures using SPECT and ultra-high-resolution fan beam collimators: comparison with parallel-hole collimators in healthy controls for a clinical reference database
Purpose The purpose of this study was to create 123 I-FP-CIT reference values for ultra-high-resolution fan beam collimators (UHR-FB) from a sample of subjects without dopaminergic degeneration and to compare them to a normal database -PPMI database- of a commercial software (DaTQUANT) obtained usin...
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| Veröffentlicht in: | Clinical and translational imaging : reviews in nuclear medicine and molecular imaging 2024, Vol.12 (3), p.347-357 |
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| creator | De Cristofaro, Maria Teresa R. Linguanti, Flavia Pepponi, Miriam Abenavoli, Elisabetta Ramat, Silvia Bessi, Valentina Passeri, Alessandro Alfarano, Vincenzo Sorbi, Sandro Sciagrà, Roberto Berti, Valentina |
| description | Purpose
The purpose of this study was to create
123
I-FP-CIT reference values for ultra-high-resolution fan beam collimators (UHR-FB) from a sample of subjects without dopaminergic degeneration and to compare them to a normal database -PPMI database- of a commercial software (DaTQUANT) obtained using high-resolution parallel-hole collimators (HR-PH).
Methods
A striatal phantom study was performed to compare UHR-FB with HR-PH and to obtain a correction factor between collimators. Normal
123
I-FP-CIT studies from 177 subjects acquired using UHR-FB were retrospectively selected on the basis of visual and semi-quantitative analysis as well as of the neurological follow-up (range of 2–9 years). SPECT images were reconstructed using the same parameters of DaTQUANT normal database and SBR values were obtained for striatal structures. Correction factor was applied to the UHR-FB database to test differences against DaTQUANT database.
Results
Correction factor obtained from the phantom study was 0.84. Uncorrected SBR values of the local database were significantly higher than PPMI database values, but no significant differences were found using corrected values. Coefficients of variations of SBR values were significantly lower in a local database than PPMI database (15% vs 20%). Significant effects of age on SBR were observed in both databases with a reduction rate for a decade of 6% in the PPMI database and 4.5% in the local database. In the latter, women had slightly higher SBR values and a steeper decline with advancing age compared to men, whereas no significant gender differences were found in the PPMI database.
Conclusion
The SBR values obtained using UHR-FB have an age-related distribution comparable to that of healthy subjects but with lower variability. The reduction rate per decade was similar between the two databases but the gender effect was found only in the local database, probably related to the better performance of UHR-FB. |
| doi_str_mv | 10.1007/s40336-023-00613-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3063599006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3063599006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c314t-a49e6b6301ae0709331ffca14ef216484c0804f086af798d87e39ca20fd9f9aa3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSMEElXpC7AaiXVgHOfmhx26Kj9SJRCUtTXXGd-4cuxgO6D7oLwPbi8SXbGxPfZ3zox1quqlwNcCsX-TWpSyq7GRNWInyvqkumiaQdT9rts9fXR-Xl2ldIeIAsVOCHFR_f7K06azDR6sh58ULR2ss_kEwcAUVlqsZ8iRfFpDzBxhYUpb5ARbsv4I375c72-B_ASbK1g92-Ncl-fgtgdXQx4OTAvo4JxdKIeY3pZiWUuvVIBfNs9QCnKOXT0Hx4_R-6lmJpfnU7n2OQaXwIQIBNpZbzU5iGw4stcME2U6UOIX1TNDLvHV3_2y-v7--nb_sb75_OHT_t1NraVoc03tyN2hkyiIscdRSmGMJtGyaUTXDq3GAVuDQ0emH4dp6FmOmho002hGInlZvTr7rjH82DhldRe26EtLJbGTu3EsgRSqOVM6hpTKtGqN5XvxpASq-wTVOUFVElQPCSosInkWpQL7I8d_1v9R_QEwC6Qu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3063599006</pqid></control><display><type>article</type><title>Reduction in variability of dopamine transporter measures using SPECT and ultra-high-resolution fan beam collimators: comparison with parallel-hole collimators in healthy controls for a clinical reference database</title><source>Springer Nature - Complete Springer Journals</source><creator>De Cristofaro, Maria Teresa R. ; Linguanti, Flavia ; Pepponi, Miriam ; Abenavoli, Elisabetta ; Ramat, Silvia ; Bessi, Valentina ; Passeri, Alessandro ; Alfarano, Vincenzo ; Sorbi, Sandro ; Sciagrà, Roberto ; Berti, Valentina</creator><creatorcontrib>De Cristofaro, Maria Teresa R. ; Linguanti, Flavia ; Pepponi, Miriam ; Abenavoli, Elisabetta ; Ramat, Silvia ; Bessi, Valentina ; Passeri, Alessandro ; Alfarano, Vincenzo ; Sorbi, Sandro ; Sciagrà, Roberto ; Berti, Valentina</creatorcontrib><description>Purpose
The purpose of this study was to create
123
I-FP-CIT reference values for ultra-high-resolution fan beam collimators (UHR-FB) from a sample of subjects without dopaminergic degeneration and to compare them to a normal database -PPMI database- of a commercial software (DaTQUANT) obtained using high-resolution parallel-hole collimators (HR-PH).
Methods
A striatal phantom study was performed to compare UHR-FB with HR-PH and to obtain a correction factor between collimators. Normal
123
I-FP-CIT studies from 177 subjects acquired using UHR-FB were retrospectively selected on the basis of visual and semi-quantitative analysis as well as of the neurological follow-up (range of 2–9 years). SPECT images were reconstructed using the same parameters of DaTQUANT normal database and SBR values were obtained for striatal structures. Correction factor was applied to the UHR-FB database to test differences against DaTQUANT database.
Results
Correction factor obtained from the phantom study was 0.84. Uncorrected SBR values of the local database were significantly higher than PPMI database values, but no significant differences were found using corrected values. Coefficients of variations of SBR values were significantly lower in a local database than PPMI database (15% vs 20%). Significant effects of age on SBR were observed in both databases with a reduction rate for a decade of 6% in the PPMI database and 4.5% in the local database. In the latter, women had slightly higher SBR values and a steeper decline with advancing age compared to men, whereas no significant gender differences were found in the PPMI database.
Conclusion
The SBR values obtained using UHR-FB have an age-related distribution comparable to that of healthy subjects but with lower variability. The reduction rate per decade was similar between the two databases but the gender effect was found only in the local database, probably related to the better performance of UHR-FB.</description><identifier>ISSN: 2281-7565</identifier><identifier>ISSN: 2281-5872</identifier><identifier>EISSN: 2281-7565</identifier><identifier>DOI: 10.1007/s40336-023-00613-0</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age factors ; Collimators ; Degeneration ; Diagnostic Radiology ; Dopamine ; Gender aspects ; High resolution ; Image reconstruction ; Imaging ; Interventional Radiology ; Medical and Radiation Physics ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Original Article ; Radiology ; Radiotherapy</subject><ispartof>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging, 2024, Vol.12 (3), p.347-357</ispartof><rights>The Author(s) 2024</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c314t-a49e6b6301ae0709331ffca14ef216484c0804f086af798d87e39ca20fd9f9aa3</cites><orcidid>0000-0002-9370-102X ; 0000-0001-9947-6559</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40336-023-00613-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40336-023-00613-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>De Cristofaro, Maria Teresa R.</creatorcontrib><creatorcontrib>Linguanti, Flavia</creatorcontrib><creatorcontrib>Pepponi, Miriam</creatorcontrib><creatorcontrib>Abenavoli, Elisabetta</creatorcontrib><creatorcontrib>Ramat, Silvia</creatorcontrib><creatorcontrib>Bessi, Valentina</creatorcontrib><creatorcontrib>Passeri, Alessandro</creatorcontrib><creatorcontrib>Alfarano, Vincenzo</creatorcontrib><creatorcontrib>Sorbi, Sandro</creatorcontrib><creatorcontrib>Sciagrà, Roberto</creatorcontrib><creatorcontrib>Berti, Valentina</creatorcontrib><title>Reduction in variability of dopamine transporter measures using SPECT and ultra-high-resolution fan beam collimators: comparison with parallel-hole collimators in healthy controls for a clinical reference database</title><title>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging</title><addtitle>Clin Transl Imaging</addtitle><description>Purpose
The purpose of this study was to create
123
I-FP-CIT reference values for ultra-high-resolution fan beam collimators (UHR-FB) from a sample of subjects without dopaminergic degeneration and to compare them to a normal database -PPMI database- of a commercial software (DaTQUANT) obtained using high-resolution parallel-hole collimators (HR-PH).
Methods
A striatal phantom study was performed to compare UHR-FB with HR-PH and to obtain a correction factor between collimators. Normal
123
I-FP-CIT studies from 177 subjects acquired using UHR-FB were retrospectively selected on the basis of visual and semi-quantitative analysis as well as of the neurological follow-up (range of 2–9 years). SPECT images were reconstructed using the same parameters of DaTQUANT normal database and SBR values were obtained for striatal structures. Correction factor was applied to the UHR-FB database to test differences against DaTQUANT database.
Results
Correction factor obtained from the phantom study was 0.84. Uncorrected SBR values of the local database were significantly higher than PPMI database values, but no significant differences were found using corrected values. Coefficients of variations of SBR values were significantly lower in a local database than PPMI database (15% vs 20%). Significant effects of age on SBR were observed in both databases with a reduction rate for a decade of 6% in the PPMI database and 4.5% in the local database. In the latter, women had slightly higher SBR values and a steeper decline with advancing age compared to men, whereas no significant gender differences were found in the PPMI database.
Conclusion
The SBR values obtained using UHR-FB have an age-related distribution comparable to that of healthy subjects but with lower variability. The reduction rate per decade was similar between the two databases but the gender effect was found only in the local database, probably related to the better performance of UHR-FB.</description><subject>Age factors</subject><subject>Collimators</subject><subject>Degeneration</subject><subject>Diagnostic Radiology</subject><subject>Dopamine</subject><subject>Gender aspects</subject><subject>High resolution</subject><subject>Image reconstruction</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Medical and Radiation Physics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Radiology</subject><subject>Radiotherapy</subject><issn>2281-7565</issn><issn>2281-5872</issn><issn>2281-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kc1u1TAQhSMEElXpC7AaiXVgHOfmhx26Kj9SJRCUtTXXGd-4cuxgO6D7oLwPbi8SXbGxPfZ3zox1quqlwNcCsX-TWpSyq7GRNWInyvqkumiaQdT9rts9fXR-Xl2ldIeIAsVOCHFR_f7K06azDR6sh58ULR2ss_kEwcAUVlqsZ8iRfFpDzBxhYUpb5ARbsv4I375c72-B_ASbK1g92-Ncl-fgtgdXQx4OTAvo4JxdKIeY3pZiWUuvVIBfNs9QCnKOXT0Hx4_R-6lmJpfnU7n2OQaXwIQIBNpZbzU5iGw4stcME2U6UOIX1TNDLvHV3_2y-v7--nb_sb75_OHT_t1NraVoc03tyN2hkyiIscdRSmGMJtGyaUTXDq3GAVuDQ0emH4dp6FmOmho002hGInlZvTr7rjH82DhldRe26EtLJbGTu3EsgRSqOVM6hpTKtGqN5XvxpASq-wTVOUFVElQPCSosInkWpQL7I8d_1v9R_QEwC6Qu</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>De Cristofaro, Maria Teresa R.</creator><creator>Linguanti, Flavia</creator><creator>Pepponi, Miriam</creator><creator>Abenavoli, Elisabetta</creator><creator>Ramat, Silvia</creator><creator>Bessi, Valentina</creator><creator>Passeri, Alessandro</creator><creator>Alfarano, Vincenzo</creator><creator>Sorbi, Sandro</creator><creator>Sciagrà, Roberto</creator><creator>Berti, Valentina</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-9370-102X</orcidid><orcidid>https://orcid.org/0000-0001-9947-6559</orcidid></search><sort><creationdate>2024</creationdate><title>Reduction in variability of dopamine transporter measures using SPECT and ultra-high-resolution fan beam collimators: comparison with parallel-hole collimators in healthy controls for a clinical reference database</title><author>De Cristofaro, Maria Teresa R. ; Linguanti, Flavia ; Pepponi, Miriam ; Abenavoli, Elisabetta ; Ramat, Silvia ; Bessi, Valentina ; Passeri, Alessandro ; Alfarano, Vincenzo ; Sorbi, Sandro ; Sciagrà, Roberto ; Berti, Valentina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-a49e6b6301ae0709331ffca14ef216484c0804f086af798d87e39ca20fd9f9aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age factors</topic><topic>Collimators</topic><topic>Degeneration</topic><topic>Diagnostic Radiology</topic><topic>Dopamine</topic><topic>Gender aspects</topic><topic>High resolution</topic><topic>Image reconstruction</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Medical and Radiation Physics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Radiology</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Cristofaro, Maria Teresa R.</creatorcontrib><creatorcontrib>Linguanti, Flavia</creatorcontrib><creatorcontrib>Pepponi, Miriam</creatorcontrib><creatorcontrib>Abenavoli, Elisabetta</creatorcontrib><creatorcontrib>Ramat, Silvia</creatorcontrib><creatorcontrib>Bessi, Valentina</creatorcontrib><creatorcontrib>Passeri, Alessandro</creatorcontrib><creatorcontrib>Alfarano, Vincenzo</creatorcontrib><creatorcontrib>Sorbi, Sandro</creatorcontrib><creatorcontrib>Sciagrà, Roberto</creatorcontrib><creatorcontrib>Berti, Valentina</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><jtitle>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Cristofaro, Maria Teresa R.</au><au>Linguanti, Flavia</au><au>Pepponi, Miriam</au><au>Abenavoli, Elisabetta</au><au>Ramat, Silvia</au><au>Bessi, Valentina</au><au>Passeri, Alessandro</au><au>Alfarano, Vincenzo</au><au>Sorbi, Sandro</au><au>Sciagrà, Roberto</au><au>Berti, Valentina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction in variability of dopamine transporter measures using SPECT and ultra-high-resolution fan beam collimators: comparison with parallel-hole collimators in healthy controls for a clinical reference database</atitle><jtitle>Clinical and translational imaging : reviews in nuclear medicine and molecular imaging</jtitle><stitle>Clin Transl Imaging</stitle><date>2024</date><risdate>2024</risdate><volume>12</volume><issue>3</issue><spage>347</spage><epage>357</epage><pages>347-357</pages><issn>2281-7565</issn><issn>2281-5872</issn><eissn>2281-7565</eissn><abstract>Purpose
The purpose of this study was to create
123
I-FP-CIT reference values for ultra-high-resolution fan beam collimators (UHR-FB) from a sample of subjects without dopaminergic degeneration and to compare them to a normal database -PPMI database- of a commercial software (DaTQUANT) obtained using high-resolution parallel-hole collimators (HR-PH).
Methods
A striatal phantom study was performed to compare UHR-FB with HR-PH and to obtain a correction factor between collimators. Normal
123
I-FP-CIT studies from 177 subjects acquired using UHR-FB were retrospectively selected on the basis of visual and semi-quantitative analysis as well as of the neurological follow-up (range of 2–9 years). SPECT images were reconstructed using the same parameters of DaTQUANT normal database and SBR values were obtained for striatal structures. Correction factor was applied to the UHR-FB database to test differences against DaTQUANT database.
Results
Correction factor obtained from the phantom study was 0.84. Uncorrected SBR values of the local database were significantly higher than PPMI database values, but no significant differences were found using corrected values. Coefficients of variations of SBR values were significantly lower in a local database than PPMI database (15% vs 20%). Significant effects of age on SBR were observed in both databases with a reduction rate for a decade of 6% in the PPMI database and 4.5% in the local database. In the latter, women had slightly higher SBR values and a steeper decline with advancing age compared to men, whereas no significant gender differences were found in the PPMI database.
Conclusion
The SBR values obtained using UHR-FB have an age-related distribution comparable to that of healthy subjects but with lower variability. The reduction rate per decade was similar between the two databases but the gender effect was found only in the local database, probably related to the better performance of UHR-FB.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40336-023-00613-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9370-102X</orcidid><orcidid>https://orcid.org/0000-0001-9947-6559</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and translational imaging : reviews in nuclear medicine and molecular imaging, 2024, Vol.12 (3), p.347-357 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Age factors Collimators Degeneration Diagnostic Radiology Dopamine Gender aspects High resolution Image reconstruction Imaging Interventional Radiology Medical and Radiation Physics Medicine Medicine & Public Health Nuclear Medicine Original Article Radiology Radiotherapy |
| title | Reduction in variability of dopamine transporter measures using SPECT and ultra-high-resolution fan beam collimators: comparison with parallel-hole collimators in healthy controls for a clinical reference database |
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