Capecitabine-Induced Genital Hand-Foot Syndrome Treated With Topical Tacrolimus
We describe a rare case of capecitabine-induced palmar-plantar erythrodysesthesia (PPE), or hand-foot syndrome (HFS), involving the genitals, which resolved with tacrolimus therapy, in a patient with cT3dN3 stage IIIc moderately differentiated proximal rectal adenocarcinoma who was undergoing neoadj...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-04, Vol.16 (4), p.e57570 |
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| creator | Chan, Bryan L Wang, Tina |
| description | We describe a rare case of capecitabine-induced palmar-plantar erythrodysesthesia (PPE), or hand-foot syndrome (HFS), involving the genitals, which resolved with tacrolimus therapy, in a patient with cT3dN3 stage IIIc moderately differentiated proximal rectal adenocarcinoma who was undergoing neoadjuvant chemotherapy. Given its severe impact on the quality of life, HFS often requires independent local anti-inflammatory treatment and subsequent dose delay and/or modification of the patient's chemotherapy. We believe that our findings in this report can aid clinicians in the early recognition and management of capecitabine-associated HFS resulting in balanitis, as prompt treatment may reduce morbidity and avoid prolonged interruption of chemotherapy in these patients. |
| doi_str_mv | 10.7759/cureus.57570 |
| format | Article |
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Given its severe impact on the quality of life, HFS often requires independent local anti-inflammatory treatment and subsequent dose delay and/or modification of the patient's chemotherapy. 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| source | PubMed Central Open Access; PubMed Central |
| subjects | Abdomen Case reports Chemotherapy Dermatitis Drug dosages Erythema Hands Hospitals Magnetic resonance imaging Patients Penis Radiation therapy Sexually transmitted diseases STD Steroids Toxicity Urology |
| title | Capecitabine-Induced Genital Hand-Foot Syndrome Treated With Topical Tacrolimus |
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