Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation

The venerable Mannich reaction using p -anisidine, an aldehyde, and a nucleophile affords a linear α-secondary amine motif. Herein, we report that a slight yet rational modification of the reaction inputs diverts this three-component reaction, providing a cyclic α-tertiary amine. 2,2-Disubstituted i...

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Veröffentlicht in:	Organic Chemistry Frontiers 2024-05, Vol.11 (11), p.3186-3195
Hauptverfasser:	Xiang, Jia-Chen, Wang, Yu-Die, Yuan, Peng, Zhu, Hui-Min, Lei, Tong, Wu, An-Xin, Liao, Zhixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Anisidine Aromatic compounds Copper Nucleophiles Oxidation Substitution reactions
Online-Zugang:	Volltext
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