Does interference with the renin-angiotensin system protect against diabetes? Evidence and mechanisms

Agents interfering with the renin–angiotensin system (RAS) were consistently shown to lower the incidence of type 2 diabetes mellitus (T2DM), as compared to other antihypertensive drugs, in hypertensive high‐risk populations. The mechanisms underlying this protective effect of RAS blockade using ang...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2012-07, Vol.14 (7), p.586-595
Hauptverfasser:	van der Zijl, N. J., Moors, C. C. M., Goossens, G. H., Blaak, E. E., Diamant, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiotensin Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - therapeutic use antihypertensive therapy Antihypertensives Beta cells Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - prevention & control Diabetic Angiopathies - blood Diabetic Angiopathies - metabolism Diabetic Angiopathies - prevention & control drug mechanism Enzyme inhibitors Evidence-Based Medicine Female Glucose metabolism Humans Hypertension - blood Hypertension - drug therapy Hypertension - physiopathology Incidence Insulin Resistance Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Male Middle Aged Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Randomized Controlled Trials as Topic Renin Renin-Angiotensin System - drug effects type 2 diabetes β cell
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