Mitochondrial-targeted fluorophore: synthesis, property and cells imaging
PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol ( BQ-mPEG ) was synthesized, which exhibited strong fluorescence at 610 nm ( f = 0.11) and a large Stoke's shift (Δ λ = 202 nm) in the aqueous solution. The fluorophore displayed a two-photon absorption characteristic and a s...
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| Veröffentlicht in: | New journal of chemistry 2024-05, Vol.48 (2), p.9136-9141 |
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| container_title | New journal of chemistry |
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| creator | Liu, Jindao Kong, Lin Chen, Yi |
| description | PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol (
BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution. The fluorophore displayed a two-photon absorption characteristic and a strong red emission (
λ
em
= 625 nm) was observed with NIR (950 nm) irradiation. The feasibility of using
BQ-mPEG
as a fluorescent imaging reagent suggested that the fluorophore targets mitochondria, and with 950 nm excitation, bright fluorescence images in HeLa live cells were observed. Furthermore, the fluorophore exhibited some advantages of high photostability and pH stability, as well as low cytotoxicity.
PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol (
BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution. |
| doi_str_mv | 10.1039/d4nj00609g |
| format | Article |
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BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution. The fluorophore displayed a two-photon absorption characteristic and a strong red emission (
λ
em
= 625 nm) was observed with NIR (950 nm) irradiation. The feasibility of using
BQ-mPEG
as a fluorescent imaging reagent suggested that the fluorophore targets mitochondria, and with 950 nm excitation, bright fluorescence images in HeLa live cells were observed. Furthermore, the fluorophore exhibited some advantages of high photostability and pH stability, as well as low cytotoxicity.
PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol (
BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/d4nj00609g</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Aqueous solutions ; Fluorescence ; Fluoroscopic imaging ; MPEG encoders ; Photon absorption ; Reagents</subject><ispartof>New journal of chemistry, 2024-05, Vol.48 (2), p.9136-9141</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c240t-2102c59e313de0d37cc4b2b287a892d80d2199dbcf17d3b58c1ea4fecf1f19ff3</cites><orcidid>0000-0002-6310-9762</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Liu, Jindao</creatorcontrib><creatorcontrib>Kong, Lin</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><title>Mitochondrial-targeted fluorophore: synthesis, property and cells imaging</title><title>New journal of chemistry</title><description>PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol (
BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution. The fluorophore displayed a two-photon absorption characteristic and a strong red emission (
λ
em
= 625 nm) was observed with NIR (950 nm) irradiation. The feasibility of using
BQ-mPEG
as a fluorescent imaging reagent suggested that the fluorophore targets mitochondria, and with 950 nm excitation, bright fluorescence images in HeLa live cells were observed. Furthermore, the fluorophore exhibited some advantages of high photostability and pH stability, as well as low cytotoxicity.
PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol (
BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution.</description><subject>Aqueous solutions</subject><subject>Fluorescence</subject><subject>Fluoroscopic imaging</subject><subject>MPEG encoders</subject><subject>Photon absorption</subject><subject>Reagents</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFkDtPwzAURi0EEqWwsCNFYkMEfG3HidlQgVJUYIE5cvxIU4U42O7Qf4-hCKb70NG9nw5Cp4CvAFNxrdmwxphj0e6hCVAuckE47KceGMtxwfghOgohMQAlhwlaPHfRqZUbtO9kn0fpWxONzmy_cd6NK-fNTRa2Q1yZ0IXLbExL4-M2k4POlOn7kHUfsu2G9hgdWNkHc_Jbp-j94f5t9pgvX-eL2e0yV4ThmBPARBXCUKDaYE1LpVhDGlKVshJEV1gTEEI3ykKpaVNUCoxk1qTZgrCWTtH57m6K8rkxIdZrt_FDellTXPCSYcFZoi52lPIuBG9sPfoU1G9rwPW3qvqOvTz9qJon-GwH-6D-uH-V9AurEGbB</recordid><startdate>20240520</startdate><enddate>20240520</enddate><creator>Liu, Jindao</creator><creator>Kong, Lin</creator><creator>Chen, Yi</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0002-6310-9762</orcidid></search><sort><creationdate>20240520</creationdate><title>Mitochondrial-targeted fluorophore: synthesis, property and cells imaging</title><author>Liu, Jindao ; Kong, Lin ; Chen, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c240t-2102c59e313de0d37cc4b2b287a892d80d2199dbcf17d3b58c1ea4fecf1f19ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aqueous solutions</topic><topic>Fluorescence</topic><topic>Fluoroscopic imaging</topic><topic>MPEG encoders</topic><topic>Photon absorption</topic><topic>Reagents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jindao</creatorcontrib><creatorcontrib>Kong, Lin</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jindao</au><au>Kong, Lin</au><au>Chen, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial-targeted fluorophore: synthesis, property and cells imaging</atitle><jtitle>New journal of chemistry</jtitle><date>2024-05-20</date><risdate>2024</risdate><volume>48</volume><issue>2</issue><spage>9136</spage><epage>9141</epage><pages>9136-9141</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol (
BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution. The fluorophore displayed a two-photon absorption characteristic and a strong red emission (
λ
em
= 625 nm) was observed with NIR (950 nm) irradiation. The feasibility of using
BQ-mPEG
as a fluorescent imaging reagent suggested that the fluorophore targets mitochondria, and with 950 nm excitation, bright fluorescence images in HeLa live cells were observed. Furthermore, the fluorophore exhibited some advantages of high photostability and pH stability, as well as low cytotoxicity.
PEGylated 2-(2-(6-(dimethylamino)benzooxazol-2-yl)vinyl)quinolin-8-ol (
BQ-mPEG
) was synthesized, which exhibited strong fluorescence at 610 nm (
f
= 0.11) and a large Stoke's shift (Δ
λ
= 202 nm) in the aqueous solution.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d4nj00609g</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6310-9762</orcidid></addata></record> |
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| ispartof | New journal of chemistry, 2024-05, Vol.48 (2), p.9136-9141 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_proquest_journals_3056740964 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Aqueous solutions Fluorescence Fluoroscopic imaging MPEG encoders Photon absorption Reagents |
| title | Mitochondrial-targeted fluorophore: synthesis, property and cells imaging |
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