Microchannel-assisted crystallization of Febuxostat and its effect on crystal size: optimization by Box-Behnken design

The aim of this research work was to investigate the impact of various process parameters on the particle size of Febuxostat (FEB) nanocrystals using response surface methodology. The continuous microchannel nanoprecipitation technique was employed to produce FEB nanoparticles with poloxamer 407 as...

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Veröffentlicht in:	Bulletin of materials science 2024-05, Vol.47 (2), p.103, Article 103
Hauptverfasser:	Patel, Arunkumar M, Patel, Sanjaykumar R
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Chemistry and Materials Science Crystallization Dependent variables Design of experiments Design optimization Drugs Engineering Flow velocity Independent variables Materials Science Microchannels Microfluidics Nanocrystals Nanoparticles Particle size Pharmaceutical industry Poloxamers Polydispersity Polymers Process parameters Response surface methodology Solvents
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