Understanding Cardiovascular Risk in Prostate Cancer: Role of Disparities, Diabetes, and Aging
Purpose of review The primary objective of this review article is to dissect the intricate relationship between disparities, aging, diabetes, and their collective influence on cardiovascular disease (CVD) risk in prostate cancer (PC) patients. We sought to answer how these determinants interact with...
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| Veröffentlicht in: | Current treatment options in cardiovascular medicine 2024-05, Vol.26 (5), p.93-109 |
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| creator | Nain, Priyanshu Seth, Lakshya Patel, Vraj Jiang, Stephanie Gopu, Gaurav Singh, Rishabh Stabellini, Nickolas Reddy, Ritu Weintraub, Neal L. Harris, Ryan A. Cullen, Jennifer Agarwal, Neeraj Moore, Justin Xavier Sayed, Nazish Guha, Avirup |
| description | Purpose of review
The primary objective of this review article is to dissect the intricate relationship between disparities, aging, diabetes, and their collective influence on cardiovascular disease (CVD) risk in prostate cancer (PC) patients. We sought to answer how these determinants interact with each other and contribute to the varying CVD outcomes observed in different subsets of PC patients.
Recent findings
It has become evident that social determinants of health (SDOH) significantly impact PC outcomes. Particularly, cardiovascular outcomes in non-Hispanic Black (NHB) patients, those from lower socioeconomic backgrounds, and residing in rural areas are notably worse. Diabetes, a growing concern worldwide, has been linked to increased PC-specific and all-cause mortality. Interestingly, recent studies highlight the potential of metformin therapy in enhancing survival rates, especially pivotal for those undergoing androgen deprivation therapy (ADT). Furthermore, the implications of age on PC are profound. The age-driven alterations in factors like allostatic load, responses to ADT, and vascular health play a crucial role in influencing CVD outcomes.
Summary
Our article highlights the multifaceted factors influencing cardiovascular risk in PC patients. Social disparities, aging, and diabetes mellitus significantly shape CVD outcomes. A holistic approach that targets both systemic and individual concerns, focusing on bridging healthcare access gaps and devising effective diabetes management strategies, is imperative. Metformin therapy emerges as a beacon of hope, especially for those patients on ADT. To improve cardiovascular outcomes in PC patients, there is an urgent need to target modifiable risk factors, emphasizing special attention to vulnerable populations. Further research is still needed to develop targeted interventions to mitigate the risk of disparities while improving cardiovascular outcomes, especially in vulnerable populations. |
| doi_str_mv | 10.1007/s11936-024-01035-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3054303276</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3054303276</sourcerecordid><originalsourceid>FETCH-LOGICAL-c270t-d1d6241709f51f049abaf2720f5fca8b3ab5dee266c064551b2b4f2800c2b1133</originalsourceid><addsrcrecordid>eNp9kEtLQzEQhYMoWKt_wFXArdHJ6z7clVofUFCK3RqS3KSk1ntrciv47029gjtXM8Oc8w1zEDqncEUByutEac0LAkwQoMAlkQdoRCUXhNOqPsw91IxUohDH6CSlNQCTvKpG6HXZNi6mXrdNaFd4qmMTuk-d7G6jI16E9IZDi59jlyW9y_vWuniDF93G4c7j25C2OoY-uHSZB21cv-8yDU9WGXiKjrzeJHf2W8doeTd7mT6Q-dP943QyJ5aV0JOGNgUTtITaS-pB1Npoz0oGXnqrK8O1kY1zrCgsFEJKapgRnlUAlhlKOR-ji4G7jd3HzqVerbtdbPNJxUEKDpyVRVaxQWXzPyk6r7YxvOv4pSiofY5qyFHlHNVPjkpmEx9MKYvblYt_6H9c348ydPE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3054303276</pqid></control><display><type>article</type><title>Understanding Cardiovascular Risk in Prostate Cancer: Role of Disparities, Diabetes, and Aging</title><source>SpringerLink Journals - AutoHoldings</source><creator>Nain, Priyanshu ; Seth, Lakshya ; Patel, Vraj ; Jiang, Stephanie ; Gopu, Gaurav ; Singh, Rishabh ; Stabellini, Nickolas ; Reddy, Ritu ; Weintraub, Neal L. ; Harris, Ryan A. ; Cullen, Jennifer ; Agarwal, Neeraj ; Moore, Justin Xavier ; Sayed, Nazish ; Guha, Avirup</creator><creatorcontrib>Nain, Priyanshu ; Seth, Lakshya ; Patel, Vraj ; Jiang, Stephanie ; Gopu, Gaurav ; Singh, Rishabh ; Stabellini, Nickolas ; Reddy, Ritu ; Weintraub, Neal L. ; Harris, Ryan A. ; Cullen, Jennifer ; Agarwal, Neeraj ; Moore, Justin Xavier ; Sayed, Nazish ; Guha, Avirup</creatorcontrib><description>Purpose of review
The primary objective of this review article is to dissect the intricate relationship between disparities, aging, diabetes, and their collective influence on cardiovascular disease (CVD) risk in prostate cancer (PC) patients. We sought to answer how these determinants interact with each other and contribute to the varying CVD outcomes observed in different subsets of PC patients.
Recent findings
It has become evident that social determinants of health (SDOH) significantly impact PC outcomes. Particularly, cardiovascular outcomes in non-Hispanic Black (NHB) patients, those from lower socioeconomic backgrounds, and residing in rural areas are notably worse. Diabetes, a growing concern worldwide, has been linked to increased PC-specific and all-cause mortality. Interestingly, recent studies highlight the potential of metformin therapy in enhancing survival rates, especially pivotal for those undergoing androgen deprivation therapy (ADT). Furthermore, the implications of age on PC are profound. The age-driven alterations in factors like allostatic load, responses to ADT, and vascular health play a crucial role in influencing CVD outcomes.
Summary
Our article highlights the multifaceted factors influencing cardiovascular risk in PC patients. Social disparities, aging, and diabetes mellitus significantly shape CVD outcomes. A holistic approach that targets both systemic and individual concerns, focusing on bridging healthcare access gaps and devising effective diabetes management strategies, is imperative. Metformin therapy emerges as a beacon of hope, especially for those patients on ADT. To improve cardiovascular outcomes in PC patients, there is an urgent need to target modifiable risk factors, emphasizing special attention to vulnerable populations. Further research is still needed to develop targeted interventions to mitigate the risk of disparities while improving cardiovascular outcomes, especially in vulnerable populations.</description><identifier>ISSN: 1092-8464</identifier><identifier>EISSN: 1534-3189</identifier><identifier>DOI: 10.1007/s11936-024-01035-5</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiology ; Health care access ; Medicine ; Medicine & Public Health ; Mortality ; Prostate cancer ; Review ; Socioeconomic factors ; Topical Collection on Cardio-oncology</subject><ispartof>Current treatment options in cardiovascular medicine, 2024-05, Vol.26 (5), p.93-109</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-d1d6241709f51f049abaf2720f5fca8b3ab5dee266c064551b2b4f2800c2b1133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11936-024-01035-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11936-024-01035-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Nain, Priyanshu</creatorcontrib><creatorcontrib>Seth, Lakshya</creatorcontrib><creatorcontrib>Patel, Vraj</creatorcontrib><creatorcontrib>Jiang, Stephanie</creatorcontrib><creatorcontrib>Gopu, Gaurav</creatorcontrib><creatorcontrib>Singh, Rishabh</creatorcontrib><creatorcontrib>Stabellini, Nickolas</creatorcontrib><creatorcontrib>Reddy, Ritu</creatorcontrib><creatorcontrib>Weintraub, Neal L.</creatorcontrib><creatorcontrib>Harris, Ryan A.</creatorcontrib><creatorcontrib>Cullen, Jennifer</creatorcontrib><creatorcontrib>Agarwal, Neeraj</creatorcontrib><creatorcontrib>Moore, Justin Xavier</creatorcontrib><creatorcontrib>Sayed, Nazish</creatorcontrib><creatorcontrib>Guha, Avirup</creatorcontrib><title>Understanding Cardiovascular Risk in Prostate Cancer: Role of Disparities, Diabetes, and Aging</title><title>Current treatment options in cardiovascular medicine</title><addtitle>Curr Treat Options Cardio Med</addtitle><description>Purpose of review
The primary objective of this review article is to dissect the intricate relationship between disparities, aging, diabetes, and their collective influence on cardiovascular disease (CVD) risk in prostate cancer (PC) patients. We sought to answer how these determinants interact with each other and contribute to the varying CVD outcomes observed in different subsets of PC patients.
Recent findings
It has become evident that social determinants of health (SDOH) significantly impact PC outcomes. Particularly, cardiovascular outcomes in non-Hispanic Black (NHB) patients, those from lower socioeconomic backgrounds, and residing in rural areas are notably worse. Diabetes, a growing concern worldwide, has been linked to increased PC-specific and all-cause mortality. Interestingly, recent studies highlight the potential of metformin therapy in enhancing survival rates, especially pivotal for those undergoing androgen deprivation therapy (ADT). Furthermore, the implications of age on PC are profound. The age-driven alterations in factors like allostatic load, responses to ADT, and vascular health play a crucial role in influencing CVD outcomes.
Summary
Our article highlights the multifaceted factors influencing cardiovascular risk in PC patients. Social disparities, aging, and diabetes mellitus significantly shape CVD outcomes. A holistic approach that targets both systemic and individual concerns, focusing on bridging healthcare access gaps and devising effective diabetes management strategies, is imperative. Metformin therapy emerges as a beacon of hope, especially for those patients on ADT. To improve cardiovascular outcomes in PC patients, there is an urgent need to target modifiable risk factors, emphasizing special attention to vulnerable populations. Further research is still needed to develop targeted interventions to mitigate the risk of disparities while improving cardiovascular outcomes, especially in vulnerable populations.</description><subject>Cardiology</subject><subject>Health care access</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Prostate cancer</subject><subject>Review</subject><subject>Socioeconomic factors</subject><subject>Topical Collection on Cardio-oncology</subject><issn>1092-8464</issn><issn>1534-3189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLQzEQhYMoWKt_wFXArdHJ6z7clVofUFCK3RqS3KSk1ntrciv47029gjtXM8Oc8w1zEDqncEUByutEac0LAkwQoMAlkQdoRCUXhNOqPsw91IxUohDH6CSlNQCTvKpG6HXZNi6mXrdNaFd4qmMTuk-d7G6jI16E9IZDi59jlyW9y_vWuniDF93G4c7j25C2OoY-uHSZB21cv-8yDU9WGXiKjrzeJHf2W8doeTd7mT6Q-dP943QyJ5aV0JOGNgUTtITaS-pB1Npoz0oGXnqrK8O1kY1zrCgsFEJKapgRnlUAlhlKOR-ji4G7jd3HzqVerbtdbPNJxUEKDpyVRVaxQWXzPyk6r7YxvOv4pSiofY5qyFHlHNVPjkpmEx9MKYvblYt_6H9c348ydPE</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Nain, Priyanshu</creator><creator>Seth, Lakshya</creator><creator>Patel, Vraj</creator><creator>Jiang, Stephanie</creator><creator>Gopu, Gaurav</creator><creator>Singh, Rishabh</creator><creator>Stabellini, Nickolas</creator><creator>Reddy, Ritu</creator><creator>Weintraub, Neal L.</creator><creator>Harris, Ryan A.</creator><creator>Cullen, Jennifer</creator><creator>Agarwal, Neeraj</creator><creator>Moore, Justin Xavier</creator><creator>Sayed, Nazish</creator><creator>Guha, Avirup</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20240501</creationdate><title>Understanding Cardiovascular Risk in Prostate Cancer: Role of Disparities, Diabetes, and Aging</title><author>Nain, Priyanshu ; Seth, Lakshya ; Patel, Vraj ; Jiang, Stephanie ; Gopu, Gaurav ; Singh, Rishabh ; Stabellini, Nickolas ; Reddy, Ritu ; Weintraub, Neal L. ; Harris, Ryan A. ; Cullen, Jennifer ; Agarwal, Neeraj ; Moore, Justin Xavier ; Sayed, Nazish ; Guha, Avirup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-d1d6241709f51f049abaf2720f5fca8b3ab5dee266c064551b2b4f2800c2b1133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiology</topic><topic>Health care access</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Prostate cancer</topic><topic>Review</topic><topic>Socioeconomic factors</topic><topic>Topical Collection on Cardio-oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nain, Priyanshu</creatorcontrib><creatorcontrib>Seth, Lakshya</creatorcontrib><creatorcontrib>Patel, Vraj</creatorcontrib><creatorcontrib>Jiang, Stephanie</creatorcontrib><creatorcontrib>Gopu, Gaurav</creatorcontrib><creatorcontrib>Singh, Rishabh</creatorcontrib><creatorcontrib>Stabellini, Nickolas</creatorcontrib><creatorcontrib>Reddy, Ritu</creatorcontrib><creatorcontrib>Weintraub, Neal L.</creatorcontrib><creatorcontrib>Harris, Ryan A.</creatorcontrib><creatorcontrib>Cullen, Jennifer</creatorcontrib><creatorcontrib>Agarwal, Neeraj</creatorcontrib><creatorcontrib>Moore, Justin Xavier</creatorcontrib><creatorcontrib>Sayed, Nazish</creatorcontrib><creatorcontrib>Guha, Avirup</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Current treatment options in cardiovascular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nain, Priyanshu</au><au>Seth, Lakshya</au><au>Patel, Vraj</au><au>Jiang, Stephanie</au><au>Gopu, Gaurav</au><au>Singh, Rishabh</au><au>Stabellini, Nickolas</au><au>Reddy, Ritu</au><au>Weintraub, Neal L.</au><au>Harris, Ryan A.</au><au>Cullen, Jennifer</au><au>Agarwal, Neeraj</au><au>Moore, Justin Xavier</au><au>Sayed, Nazish</au><au>Guha, Avirup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding Cardiovascular Risk in Prostate Cancer: Role of Disparities, Diabetes, and Aging</atitle><jtitle>Current treatment options in cardiovascular medicine</jtitle><stitle>Curr Treat Options Cardio Med</stitle><date>2024-05-01</date><risdate>2024</risdate><volume>26</volume><issue>5</issue><spage>93</spage><epage>109</epage><pages>93-109</pages><issn>1092-8464</issn><eissn>1534-3189</eissn><abstract>Purpose of review
The primary objective of this review article is to dissect the intricate relationship between disparities, aging, diabetes, and their collective influence on cardiovascular disease (CVD) risk in prostate cancer (PC) patients. We sought to answer how these determinants interact with each other and contribute to the varying CVD outcomes observed in different subsets of PC patients.
Recent findings
It has become evident that social determinants of health (SDOH) significantly impact PC outcomes. Particularly, cardiovascular outcomes in non-Hispanic Black (NHB) patients, those from lower socioeconomic backgrounds, and residing in rural areas are notably worse. Diabetes, a growing concern worldwide, has been linked to increased PC-specific and all-cause mortality. Interestingly, recent studies highlight the potential of metformin therapy in enhancing survival rates, especially pivotal for those undergoing androgen deprivation therapy (ADT). Furthermore, the implications of age on PC are profound. The age-driven alterations in factors like allostatic load, responses to ADT, and vascular health play a crucial role in influencing CVD outcomes.
Summary
Our article highlights the multifaceted factors influencing cardiovascular risk in PC patients. Social disparities, aging, and diabetes mellitus significantly shape CVD outcomes. A holistic approach that targets both systemic and individual concerns, focusing on bridging healthcare access gaps and devising effective diabetes management strategies, is imperative. Metformin therapy emerges as a beacon of hope, especially for those patients on ADT. To improve cardiovascular outcomes in PC patients, there is an urgent need to target modifiable risk factors, emphasizing special attention to vulnerable populations. Further research is still needed to develop targeted interventions to mitigate the risk of disparities while improving cardiovascular outcomes, especially in vulnerable populations.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11936-024-01035-5</doi><tpages>17</tpages></addata></record> |
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| subjects | Cardiology Health care access Medicine Medicine & Public Health Mortality Prostate cancer Review Socioeconomic factors Topical Collection on Cardio-oncology |
| title | Understanding Cardiovascular Risk in Prostate Cancer: Role of Disparities, Diabetes, and Aging |
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