The Clinical Significance of Lipids/Lipoproteins Impairment in the Context of Cirrhosis: An Updated Review
The liver contributes substantially to the metabolic transformation and transport of lipids and lipoproteins. These bioactive substances represent a heterogeneous group of molecules with pivotal roles in diverse pathological processes as well as disease progression, the advent of complications, and...
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| Veröffentlicht in: | Gene expression 2022-09, Vol.21 (1), p.2-8 |
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| container_title | Gene expression |
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| creator | Cui, Binxin Yang, Wanting Guo, Gaoyue Fan, Xiaofei Wang, Xiaoyu Hui, Yangyang Wang, Sipu Jiang, Kui Liu, Wentian Liu, Junling Sun, Chao |
| description | The liver contributes substantially to the metabolic transformation and transport of lipids and lipoproteins. These bioactive substances represent a heterogeneous group of molecules with pivotal roles in diverse pathological processes as well as disease progression, the advent of complications, and the response to specific treatments in the context of cirrhosis. The present mini-review aims to summarize the underlying mechanisms regarding lipid changes across divergent circumstances. Recent evidence suggests the prognostic value of lipids/lipoproteins and their close relationship to an increased risk mortality among cirrhotic patients. However, more research regarding the development of risk stratification and therapeutic strategies based on altered lipid profiles in patients with cirrhosis is warranted. |
| doi_str_mv | 10.14218/GEJLR.2022.00003 |
| format | Article |
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These bioactive substances represent a heterogeneous group of molecules with pivotal roles in diverse pathological processes as well as disease progression, the advent of complications, and the response to specific treatments in the context of cirrhosis. The present mini-review aims to summarize the underlying mechanisms regarding lipid changes across divergent circumstances. Recent evidence suggests the prognostic value of lipids/lipoproteins and their close relationship to an increased risk mortality among cirrhotic patients. However, more research regarding the development of risk stratification and therapeutic strategies based on altered lipid profiles in patients with cirrhosis is warranted.</description><identifier>ISSN: 1052-2166</identifier><identifier>EISSN: 1555-3884</identifier><identifier>DOI: 10.14218/GEJLR.2022.00003</identifier><language>eng</language><publisher>Sugar Land: Xia & He Publishing</publisher><subject>Alcohol ; Apolipoproteins ; Cholesterol ; Cirrhosis ; Context ; Dehydrogenases ; Genotype & phenotype ; Hepatitis B ; High density lipoprotein ; Lipid metabolism ; Lipids ; Lipoproteins ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Metabolic disorders ; Polymorphism ; Proteins ; Thyroid gland</subject><ispartof>Gene expression, 2022-09, Vol.21 (1), p.2-8</ispartof><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). 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However, more research regarding the development of risk stratification and therapeutic strategies based on altered lipid profiles in patients with cirrhosis is warranted.</description><subject>Alcohol</subject><subject>Apolipoproteins</subject><subject>Cholesterol</subject><subject>Cirrhosis</subject><subject>Context</subject><subject>Dehydrogenases</subject><subject>Genotype & phenotype</subject><subject>Hepatitis B</subject><subject>High density lipoprotein</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Metabolic disorders</subject><subject>Polymorphism</subject><subject>Proteins</subject><subject>Thyroid gland</subject><issn>1052-2166</issn><issn>1555-3884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNotkE9PwzAMxSMEEmPwAbhF4tzNSZqu4zZVYwxVQhrbOeoSh2Xa0pKUf9-edsOXZ8nv2daPkHsGI5Zylo8X85dyNeLA-Qi6EhdkwKSUicjz9LLrQfKEsyy7Jjcx7gE4THM-IPv1DmlxcN7p6kDf3Lt3tmu9RlpbWrrGmTjupG5C3aLzkS6PTeXCEX1LnadtH699iz9tHyhcCLs6uvhIZ55uGlO1aOgKvxx-35IrWx0i3v3rkGye5uviOSlfF8tiViaa5UIkmYDtVFo2sel0m0stDUsRkFujq61FzWXeTyGT0oKRIjPItQbDBGfCghVD8nDe27388YmxVfv6M_jupBIgUy6YnEDnYmeXDnWMAa1qgjtW4VcxUCek6oRU9UjVCan4A9EpacA</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Cui, Binxin</creator><creator>Yang, Wanting</creator><creator>Guo, Gaoyue</creator><creator>Fan, Xiaofei</creator><creator>Wang, Xiaoyu</creator><creator>Hui, Yangyang</creator><creator>Wang, Sipu</creator><creator>Jiang, Kui</creator><creator>Liu, Wentian</creator><creator>Liu, Junling</creator><creator>Sun, Chao</creator><general>Xia & He Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0001-5885-5931</orcidid><orcidid>https://orcid.org/0000-0002-0380-7999</orcidid></search><sort><creationdate>20220901</creationdate><title>The Clinical Significance of Lipids/Lipoproteins Impairment in the Context of Cirrhosis: An Updated Review</title><author>Cui, Binxin ; 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| subjects | Alcohol Apolipoproteins Cholesterol Cirrhosis Context Dehydrogenases Genotype & phenotype Hepatitis B High density lipoprotein Lipid metabolism Lipids Lipoproteins Liver cancer Liver cirrhosis Liver diseases Metabolic disorders Polymorphism Proteins Thyroid gland |
| title | The Clinical Significance of Lipids/Lipoproteins Impairment in the Context of Cirrhosis: An Updated Review |
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