Reactive Oxygen Species in Cancer Management: Understanding the Transformation of Antagonists Turning Allies

[...]of oxidative stress, which is powered by a high degree of mitochondrial ROS generation, this altered microenvironment is nourished by a hypoxic and acidic milieu. [...]Fe-S] clusters are the primary cellular target of (02·") mediated toxicity due to electrostatic attraction. The transition metal-catalyzed reduction in H2O2 produces a highly reactive hydroxyl radical (·0H) [15] via the Fenton reaction without an antioxidant protection system. [...]excessive 02·"/ H2O2 production causes a cascade of radical chain reactions that damage important biomolecules and promote oxidative stress. The second cytochrome b heme (bH), which is located closer to the matrix side of the membrane, accepts one electron from the first heme and reduces ubiquinone to form ubisemiquinone, which is then reduced by another electron to form ubiquinol [22]. Because the structure and functional mechanisms of complex I are still unknown, inhibiting it is a good way to study it.