Involvement of TAL1-microRNA Axis in the Progression of T-cell Acute Lymphoblastic Leukemia

The T-cell acute lymphoblastic leukemia 1 (TAL-1) transcription factor is crucial for T-cell differentiation, but the ectopic expression in 30% of cases can disrupt normal differentiation, and promote cancer progression. This can be due to microRNA (miRNA) dysregulation or other oncogenes. The prese...

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Veröffentlicht in:	Gene expression 2024-03, Vol.23 (1), p.24-30
Hauptverfasser:	Purrahman, Daryush, Yousefi, Homayon, Shojaeian, Ali, khedri, Reza, Fadaei, Mahsa, Mahmoudian-Sani, Mohammad-Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adults Binding sites Blood Cancer Cell differentiation Chemotherapy Cyclin-dependent kinases Differentiation (biology) Ectopic expression Epigenetics Gene expression Hypotheses Kinases Leukemia Lymphocytes T MicroRNAs miRNA Mutation Pathogenesis Pediatrics Physiology Prognosis Proteins Ribonucleic acid RNA Stem cells Transcription factors Tumors
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