Spectrophotometric estimation of dapsone in Schiff base in its pharmaceutical preparation using charge transfer complex method

The research included the development of a new and sensitive spectroscopic method for the estimation of dapsone in aqueous media, the method depends on the interaction of the Schiff base of the drug dapsone with the reagent 8-hydroxyquinoline in a basic medium and the additions were supplemented wit...

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Hauptverfasser:	Mahmood, Sabreen Shakir, Ahmed, Eman Diab, Alwan, Liqaa Hussein
Format:	Tagungsbericht
Sprache:	eng
Schlagworte:	Absorbance Aqueous solutions Charge transfer Diaminodiphenylsulfone Distilled water Hydroxyquinoline Imines Luminous intensity Pharmaceuticals Reagents Spectrophotometry
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creator	Mahmood, Sabreen Shakir Ahmed, Eman Diab Alwan, Liqaa Hussein
description	The research included the development of a new and sensitive spectroscopic method for the estimation of dapsone in aqueous media, the method depends on the interaction of the Schiff base of the drug dapsone with the reagent 8-hydroxyquinoline in a basic medium and the additions were supplemented with distilled water to give a light yellow complex whose absorption intensity depends on the concentration of dapsone in the Schiff base and gives higher Absorbance at wavelength 350 nm, law limits were between 0.5-4.5 µg. ml−1 of dapsone, and molar absorbance was 6.257×103 L. mol−1. cm−1, the recovery rate is 100.1620%, and the relative standard deviation does not exceed 0.1430%, and the method was applied in the estimation of dapsone in its pharmaceutical formulation in the form of tablets.
doi_str_mv	10.1063/5.0209926
format	Conference Proceeding
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subjects	Absorbance Aqueous solutions Charge transfer Diaminodiphenylsulfone Distilled water Hydroxyquinoline Imines Luminous intensity Pharmaceuticals Reagents Spectrophotometry
title	Spectrophotometric estimation of dapsone in Schiff base in its pharmaceutical preparation using charge transfer complex method
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