No safe haven: Loss of avirulence in the plant pathogen Leptosphaeria maculans by DNA duplication and repeat‐induced point mutation
Microbes can overcome the ability of plant resistance genes to confer protection against disease by mutating their corresponding avirulence genes. The fungus Leptosphaeria maculans causes blackleg disease on canola crops and subverts Brassica napus resistance genes through several DNA mutation mecha...
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| Veröffentlicht in: | Plant pathology 2024-06, Vol.73 (5), p.1127-1135 |
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| creator | Idnurm, Alexander McCallum, Alec J. Van de Wouw, Angela P. |
| description | Microbes can overcome the ability of plant resistance genes to confer protection against disease by mutating their corresponding avirulence genes. The fungus
Leptosphaeria maculans
causes blackleg disease on canola crops and subverts
Brassica napus
resistance genes through several DNA mutation mechanisms. One of these is repeat‐induced point (RIP) mutation, which can ‘leak’ into the avirulence genes from the adjacent repetitive sequences that the mutation process is targeting. Here, we identified populations of
L
.
maculans
in Australia that have extensive RIP mutations in the avirulence gene
AvrLm2
and show that this has been triggered by a duplication of the gene and surrounding DNA that includes the distant (>55 kb in total)
AvrLm6
gene. This finding provides another mechanism of mutation by which pathogens can overcome host resistance, and more broadly contributes to understanding the complex balance between gene duplication and genome defence. |
| doi_str_mv | 10.1111/ppa.13889 |
| format | Article |
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Leptosphaeria maculans
causes blackleg disease on canola crops and subverts
Brassica napus
resistance genes through several DNA mutation mechanisms. One of these is repeat‐induced point (RIP) mutation, which can ‘leak’ into the avirulence genes from the adjacent repetitive sequences that the mutation process is targeting. Here, we identified populations of
L
.
maculans
in Australia that have extensive RIP mutations in the avirulence gene
AvrLm2
and show that this has been triggered by a duplication of the gene and surrounding DNA that includes the distant (>55 kb in total)
AvrLm6
gene. This finding provides another mechanism of mutation by which pathogens can overcome host resistance, and more broadly contributes to understanding the complex balance between gene duplication and genome defence.</description><identifier>ISSN: 0032-0862</identifier><identifier>EISSN: 1365-3059</identifier><identifier>DOI: 10.1111/ppa.13889</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><subject>Blackleg ; Deoxyribonucleic acid ; DNA ; Gene duplication ; Genes ; Genomes ; Leptosphaeria maculans ; Mutation ; Pathogens ; Plant resistance ; Point mutation</subject><ispartof>Plant pathology, 2024-06, Vol.73 (5), p.1127-1135</ispartof><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c252t-9171b7338551b03d2b94c53647b2c81a517966f7de969537e34e96c54704601f3</cites><orcidid>0009-0008-4370-5875 ; 0000-0001-5995-7040 ; 0000-0001-5147-0393</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Idnurm, Alexander</creatorcontrib><creatorcontrib>McCallum, Alec J.</creatorcontrib><creatorcontrib>Van de Wouw, Angela P.</creatorcontrib><title>No safe haven: Loss of avirulence in the plant pathogen Leptosphaeria maculans by DNA duplication and repeat‐induced point mutation</title><title>Plant pathology</title><description>Microbes can overcome the ability of plant resistance genes to confer protection against disease by mutating their corresponding avirulence genes. The fungus
Leptosphaeria maculans
causes blackleg disease on canola crops and subverts
Brassica napus
resistance genes through several DNA mutation mechanisms. One of these is repeat‐induced point (RIP) mutation, which can ‘leak’ into the avirulence genes from the adjacent repetitive sequences that the mutation process is targeting. Here, we identified populations of
L
.
maculans
in Australia that have extensive RIP mutations in the avirulence gene
AvrLm2
and show that this has been triggered by a duplication of the gene and surrounding DNA that includes the distant (>55 kb in total)
AvrLm6
gene. This finding provides another mechanism of mutation by which pathogens can overcome host resistance, and more broadly contributes to understanding the complex balance between gene duplication and genome defence.</description><subject>Blackleg</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gene duplication</subject><subject>Genes</subject><subject>Genomes</subject><subject>Leptosphaeria maculans</subject><subject>Mutation</subject><subject>Pathogens</subject><subject>Plant resistance</subject><subject>Point mutation</subject><issn>0032-0862</issn><issn>1365-3059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNotkL1OwzAURi0EEqUw8AZXYmJIseM4idmq8itFZYE5chyHpGptYzuVurGw84w8CablLvdK39F3pYPQJcEzEufGWjEjtCz5EZoQmrOEYsaP0QRjmia4zNNTdOb9CmPCOC8n6GtpwItOQS-2St9CZbwH04HYDm5cKy0VDBpCr8CuhQ5gRejNu9JQKRuMt71QbhCwEXKMuYdmB3fLObSjXQ9ShMFoELoFp6wS4efze9DtKFUL1gyxbTOGPXOOTjqx9urif0_R28P96-IpqV4enxfzKpEpS0PCSUGagtKSMdJg2qYNzySjeVY0qSyJYKTged4VreI5Z7RQNIuXZFmBsxyTjk7R1aHXOvMxKh_qlRmdji_r6IlklBJSROr6QEkXbTjV1dYNG-F2NcH1n-U6Wq73lukvFutwrA</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Idnurm, Alexander</creator><creator>McCallum, Alec J.</creator><creator>Van de Wouw, Angela P.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0009-0008-4370-5875</orcidid><orcidid>https://orcid.org/0000-0001-5995-7040</orcidid><orcidid>https://orcid.org/0000-0001-5147-0393</orcidid></search><sort><creationdate>202406</creationdate><title>No safe haven: Loss of avirulence in the plant pathogen Leptosphaeria maculans by DNA duplication and repeat‐induced point mutation</title><author>Idnurm, Alexander ; McCallum, Alec J. ; Van de Wouw, Angela P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c252t-9171b7338551b03d2b94c53647b2c81a517966f7de969537e34e96c54704601f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Blackleg</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Gene duplication</topic><topic>Genes</topic><topic>Genomes</topic><topic>Leptosphaeria maculans</topic><topic>Mutation</topic><topic>Pathogens</topic><topic>Plant resistance</topic><topic>Point mutation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Idnurm, Alexander</creatorcontrib><creatorcontrib>McCallum, Alec J.</creatorcontrib><creatorcontrib>Van de Wouw, Angela P.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Plant pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Idnurm, Alexander</au><au>McCallum, Alec J.</au><au>Van de Wouw, Angela P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No safe haven: Loss of avirulence in the plant pathogen Leptosphaeria maculans by DNA duplication and repeat‐induced point mutation</atitle><jtitle>Plant pathology</jtitle><date>2024-06</date><risdate>2024</risdate><volume>73</volume><issue>5</issue><spage>1127</spage><epage>1135</epage><pages>1127-1135</pages><issn>0032-0862</issn><eissn>1365-3059</eissn><abstract>Microbes can overcome the ability of plant resistance genes to confer protection against disease by mutating their corresponding avirulence genes. The fungus
Leptosphaeria maculans
causes blackleg disease on canola crops and subverts
Brassica napus
resistance genes through several DNA mutation mechanisms. One of these is repeat‐induced point (RIP) mutation, which can ‘leak’ into the avirulence genes from the adjacent repetitive sequences that the mutation process is targeting. Here, we identified populations of
L
.
maculans
in Australia that have extensive RIP mutations in the avirulence gene
AvrLm2
and show that this has been triggered by a duplication of the gene and surrounding DNA that includes the distant (>55 kb in total)
AvrLm6
gene. This finding provides another mechanism of mutation by which pathogens can overcome host resistance, and more broadly contributes to understanding the complex balance between gene duplication and genome defence.</abstract><cop>Oxford</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/ppa.13889</doi><tpages>9</tpages><orcidid>https://orcid.org/0009-0008-4370-5875</orcidid><orcidid>https://orcid.org/0000-0001-5995-7040</orcidid><orcidid>https://orcid.org/0000-0001-5147-0393</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Plant pathology, 2024-06, Vol.73 (5), p.1127-1135 |
| issn | 0032-0862 1365-3059 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Blackleg Deoxyribonucleic acid DNA Gene duplication Genes Genomes Leptosphaeria maculans Mutation Pathogens Plant resistance Point mutation |
| title | No safe haven: Loss of avirulence in the plant pathogen Leptosphaeria maculans by DNA duplication and repeat‐induced point mutation |
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