Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications
In this article, the synthesis of four novel bioelastomers known as poly (xylitol sebacate) (PXS), poly (xylitol adipate) (PXA), poly (sorbitol sebacate) (PSS), and poly (sorbitol adipate) (PSA) was carried out through bulk polymerization, followed by their blending using the solution method. Six bl...
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| Veröffentlicht in: | Journal of applied polymer science 2024-06, Vol.141 (22), p.n/a |
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| creator | Norouznezhad, Afshin Mir Mohamad Sadeghi, Gity |
| description | In this article, the synthesis of four novel bioelastomers known as poly (xylitol sebacate) (PXS), poly (xylitol adipate) (PXA), poly (sorbitol sebacate) (PSS), and poly (sorbitol adipate) (PSA) was carried out through bulk polymerization, followed by their blending using the solution method. Six blends were prepared namely PXS25/PSS75, PXS50/PSS50, PXS75/PSS25, PXS50/PXA50, PSA50/PXA50, and PSS50/PSA50. After blending, a thermal curing process was applied to the samples. The intrinsic viscosity, density, Tg, hydrophilicity, degradation, wound healing, and mechanical properties of polymers and blends were measured to investigate the effects of blending. Analyzing hardness, modulus, stress at breakpoint, degradation, and hydrophilicity data showed that the mechanical properties of bioelastomers are adjustable by blending for tissue engineering. Furthermore, the scratch assay proved the biocompatibility of pure polymers and indicated that blending does not have a negative impact on this matter.
Synthesis, blending, and curing of poly (polyol sebacate) and poly (polyol adipate) bioelastomers. |
| doi_str_mv | 10.1002/app.55453 |
| format | Article |
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Synthesis, blending, and curing of poly (polyol sebacate) and poly (polyol adipate) bioelastomers.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.55453</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Biocompatibility ; biodegradable ; Biomedical engineering ; Biomedical materials ; Blending effects ; blends ; Bulk polymerization ; Degradation ; Hydrophilicity ; Mechanical properties ; Polymer blends ; Polymers ; Soft tissues ; Sorbitol ; Tissue engineering ; Wound healing ; Xylitol</subject><ispartof>Journal of applied polymer science, 2024-06, Vol.141 (22), p.n/a</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2573-3422dc34698b8685b796b7f9218efcfa5577fa1b69ff5e1b4d3e60bfa6900fe53</cites><orcidid>0000-0003-2209-4792 ; 0009-0000-2271-3915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.55453$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.55453$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids></links><search><creatorcontrib>Norouznezhad, Afshin</creatorcontrib><creatorcontrib>Mir Mohamad Sadeghi, Gity</creatorcontrib><title>Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications</title><title>Journal of applied polymer science</title><description>In this article, the synthesis of four novel bioelastomers known as poly (xylitol sebacate) (PXS), poly (xylitol adipate) (PXA), poly (sorbitol sebacate) (PSS), and poly (sorbitol adipate) (PSA) was carried out through bulk polymerization, followed by their blending using the solution method. Six blends were prepared namely PXS25/PSS75, PXS50/PSS50, PXS75/PSS25, PXS50/PXA50, PSA50/PXA50, and PSS50/PSA50. After blending, a thermal curing process was applied to the samples. The intrinsic viscosity, density, Tg, hydrophilicity, degradation, wound healing, and mechanical properties of polymers and blends were measured to investigate the effects of blending. Analyzing hardness, modulus, stress at breakpoint, degradation, and hydrophilicity data showed that the mechanical properties of bioelastomers are adjustable by blending for tissue engineering. Furthermore, the scratch assay proved the biocompatibility of pure polymers and indicated that blending does not have a negative impact on this matter.
Synthesis, blending, and curing of poly (polyol sebacate) and poly (polyol adipate) bioelastomers.</description><subject>Biocompatibility</subject><subject>biodegradable</subject><subject>Biomedical engineering</subject><subject>Biomedical materials</subject><subject>Blending effects</subject><subject>blends</subject><subject>Bulk polymerization</subject><subject>Degradation</subject><subject>Hydrophilicity</subject><subject>Mechanical properties</subject><subject>Polymer blends</subject><subject>Polymers</subject><subject>Soft tissues</subject><subject>Sorbitol</subject><subject>Tissue engineering</subject><subject>Wound healing</subject><subject>Xylitol</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kL9OwzAQxi0EEqUw8AaWWOiQ1k5iJx6rqvyRKtEBZstOzpWrNDZ2KtRH4K1JGhYGlruTvt99d_oQuqdkTglJF8r7OWM5yy7QhBJRJDlPy0s06TWalEKwa3QT454QShnhE_S9NgaqLmJnsG6grW27w941J_w4VNfgCFpVqoMZVm39V1K19WdFWweNip07QIjYuICjMx3ubIxHwNDubAsQBmvbDvABalup3sD7ph8669p4i66MaiLc_fYp-nhav69eks3b8-tquUmqlBVZkuVpWldZzkWpS14yXQiuCyNSWoKpjGKsKIyimgtjGFCd1xlwoo3ighADLJuih9HXB_d5hNjJvTuGtj8pM5KLtKSc0Z6ajVQVXIwBjPTBHlQ4SUrkkLTsf5fnpHt2MbJftoHT_6Bcbrfjxg-JQIIc</recordid><startdate>20240610</startdate><enddate>20240610</enddate><creator>Norouznezhad, Afshin</creator><creator>Mir Mohamad Sadeghi, Gity</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-2209-4792</orcidid><orcidid>https://orcid.org/0009-0000-2271-3915</orcidid></search><sort><creationdate>20240610</creationdate><title>Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications</title><author>Norouznezhad, Afshin ; Mir Mohamad Sadeghi, Gity</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2573-3422dc34698b8685b796b7f9218efcfa5577fa1b69ff5e1b4d3e60bfa6900fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biocompatibility</topic><topic>biodegradable</topic><topic>Biomedical engineering</topic><topic>Biomedical materials</topic><topic>Blending effects</topic><topic>blends</topic><topic>Bulk polymerization</topic><topic>Degradation</topic><topic>Hydrophilicity</topic><topic>Mechanical properties</topic><topic>Polymer blends</topic><topic>Polymers</topic><topic>Soft tissues</topic><topic>Sorbitol</topic><topic>Tissue engineering</topic><topic>Wound healing</topic><topic>Xylitol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norouznezhad, Afshin</creatorcontrib><creatorcontrib>Mir Mohamad Sadeghi, Gity</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norouznezhad, Afshin</au><au>Mir Mohamad Sadeghi, Gity</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications</atitle><jtitle>Journal of applied polymer science</jtitle><date>2024-06-10</date><risdate>2024</risdate><volume>141</volume><issue>22</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>In this article, the synthesis of four novel bioelastomers known as poly (xylitol sebacate) (PXS), poly (xylitol adipate) (PXA), poly (sorbitol sebacate) (PSS), and poly (sorbitol adipate) (PSA) was carried out through bulk polymerization, followed by their blending using the solution method. Six blends were prepared namely PXS25/PSS75, PXS50/PSS50, PXS75/PSS25, PXS50/PXA50, PSA50/PXA50, and PSS50/PSA50. After blending, a thermal curing process was applied to the samples. The intrinsic viscosity, density, Tg, hydrophilicity, degradation, wound healing, and mechanical properties of polymers and blends were measured to investigate the effects of blending. Analyzing hardness, modulus, stress at breakpoint, degradation, and hydrophilicity data showed that the mechanical properties of bioelastomers are adjustable by blending for tissue engineering. Furthermore, the scratch assay proved the biocompatibility of pure polymers and indicated that blending does not have a negative impact on this matter.
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| subjects | Biocompatibility biodegradable Biomedical engineering Biomedical materials Blending effects blends Bulk polymerization Degradation Hydrophilicity Mechanical properties Polymer blends Polymers Soft tissues Sorbitol Tissue engineering Wound healing Xylitol |
| title | Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications |
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