A Dose Escalation Trial of Biweekly Docetaxel and Gemcitabine with Filgrastim or Pegfilgrastim for the Treatment of Patients with Advanced Solid Tumors

Background/Aims: A single-institution phase I trial to determine the feasibility of using filgrastim or pegfilgrastim to increase the dose intensity of biweekly docetaxel and gemcitabine. Methods: Patients with metastatic solid tumors received gemcitabine 3,000 mg/m 2 and increasing doses of docetax...

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Veröffentlicht in:	Chemotherapy (Basel) 2010-01, Vol.56 (2), p.135-141
Hauptverfasser:	Dragnev, Konstantin H., Hardin, Steven B., Pipas, J. Marc, Davis, Thomas H., Rigas, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Chemotherapy Clinical outcomes Clinical Study Clinical trials Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Dose-Response Relationship, Drug Drug dosages Female Filgrastim Granulocyte Colony-Stimulating Factor - therapeutic use Humans Male Maximum Tolerated Dose Middle Aged Neoplasm Metastasis Neoplasms - drug therapy Pharmacology Polyethylene Glycols Prescription drugs Recombinant Proteins Taxoids - administration & dosage
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