Synthesis of 2‐Quinolones based on Visible Light‐Catalyzed Annulation of Diazo compounds

Herein, we report a photocatalytic method for the synthesis of 2‐quinolones under mild conditions by employing α‐diazo acetamide as substrates. The use of Eosin Y as a photocatalyst allows an economical and environmentally benign synthetic method. The process involves the generation of radicals from...

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Veröffentlicht in:	Advanced synthesis & catalysis 2024-04, Vol.366 (8), p.1827-1832
Hauptverfasser:	Bae, Jaehee, Chae, Jiyoung, Park, Cheol‐Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical reactions Diazo compounds Electron transfer PCET Photocatalysis Quinolones Radical reactions Substrates Synthesis
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creator	Bae, Jaehee Chae, Jiyoung Park, Cheol‐Min
description	Herein, we report a photocatalytic method for the synthesis of 2‐quinolones under mild conditions by employing α‐diazo acetamide as substrates. The use of Eosin Y as a photocatalyst allows an economical and environmentally benign synthetic method. The process involves the generation of radicals from diazo compounds promoted by a visible‐light‐induced proton‐coupled electron transfer (PCET) mechanism. The method demonstrates a broad substrate scope to provide various aryl‐ and alkyl‐substituted 2‐quinolones. To support the proposed mechanism, a series of mechanistic experiments were conducted.
doi_str_mv	10.1002/adsc.202301220
format	Article
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subjects	Chemical reactions Diazo compounds Electron transfer PCET Photocatalysis Quinolones Radical reactions Substrates Synthesis
title	Synthesis of 2‐Quinolones based on Visible Light‐Catalyzed Annulation of Diazo compounds
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