Different Role of cAMP Pathway on the Human Mast Cells HMC-1560 and HMC-1560,816 Activation

ABSTRACT HMC‐1 are inflammatory cells that release vasoactive substances such as histamine. These cells have the c‐kit receptor permanently activated in the membrane due to mutations in the proto‐oncogene c‐kit: Val‐560 → Gly and Asp‐816 → Val. Thus, there are two known cellular lines: HMC‐1560 and...

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