Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells

Abstract Background: An investigation of the mechanisms underlying the production of inflammatory cytokines through the stimulation of microorganisms on gingival epithelial cells may provide insights into the pathogenesis of the initiation of periodontitis. Lipid rafts, microdomains in the cell memb...

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Veröffentlicht in:	Cellular physiology and biochemistry 2016-01, Vol.39 (5), p.1777-1786
Hauptverfasser:	Imai, Haruka, Fujita, Tsuyoshi, Kajiya, Mikihito, Ouhara, Kazuhisa, Yoshimoto, Tetsuya, Matsuda, Shinji, Takeda, Katsuhiro, Kurihara, Hidemi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregatibacter actinomycetemcomitans Aggregatibacter actinomycetemcomitans - growth & development Aggregatibacter actinomycetemcomitans - metabolism Antibodies beta-Cyclodextrins - pharmacology Cell Line Cholera Cholesterol Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - microbiology Epithelial Cells - ultrastructure Gene Expression Regulation Gingiva - immunology Gingiva - microbiology Gingiva - pathology Gingival epithelial cell Gum disease Host-Pathogen Interactions Humans Insulin Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-8 - genetics Interleukin-8 - immunology Kinases Laboratories Lipid raft Lipids Membrane Microdomains - drug effects Membrane Microdomains - immunology Membrane Microdomains - microbiology Membrane Microdomains - pathology Membranes Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - immunology Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - immunology Original Paper p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - immunology Phosphorylation Protein Transport Reagents RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Toll-tike receptor Toxins Tumor Necrosis Factor-alpha - pharmacology
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