Synthesis and Properties of New Conjugates of Isatin and Bicyclic Monoterpenes
Conjugates of isatin and hydrazones based on (+)-camphor and (–)-fenchone were synthesized for the first time. The physicochemical properties of the synthesized compounds have been studied, and for the hydrazone product of fenchone and isatin X-ray diffraction data have been obtained. Molecular mode...
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| Veröffentlicht in: | Russian journal of general chemistry 2024, Vol.94 (1), p.81-92 |
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| container_title | Russian journal of general chemistry |
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| creator | Yarovaya, O. I. Baev, D. S. Kovaleva, K. S. Gatilov, Yu. V. Meshkova, Yu. V. Marinina, M. K. Oreshko, V. V. Tolstikova, T. G. Salakhutdinov, N. F. |
| description | Conjugates of isatin and hydrazones based on (+)-camphor and (–)-fenchone were synthesized for the first time. The physicochemical properties of the synthesized compounds have been studied, and for the hydrazone product of fenchone and isatin X-ray diffraction data have been obtained. Molecular modeling of the possible interaction of new compounds with the active site of the basic protease 3CLpro of the SARS-CoV-2 virus was carried out, and the properties of isatin-terpene compounds as inhibitors of the 3CLpro protease were studied. It was found that the new conjugates do not exhibit inhibitory properties against 3CLpro, which makes it possible to clarify the direction of further chemical modifications of monoterpenoid derivatives in order to obtain molecules with antiviral properties. |
| doi_str_mv | 10.1134/S1070363224010080 |
| format | Article |
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Molecular modeling of the possible interaction of new compounds with the active site of the basic protease 3CLpro of the SARS-CoV-2 virus was carried out, and the properties of isatin-terpene compounds as inhibitors of the 3CLpro protease were studied. It was found that the new conjugates do not exhibit inhibitory properties against 3CLpro, which makes it possible to clarify the direction of further chemical modifications of monoterpenoid derivatives in order to obtain molecules with antiviral properties.</description><subject>Amino acids</subject><subject>Antiviral agents</subject><subject>Camphor</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Conjugates</subject><subject>Diffraction</subject><subject>Health aspects</subject><subject>Hydrazones</subject><subject>Marburg virus disease</subject><subject>Protease</subject><subject>Protease inhibitors</subject><subject>Proteases</subject><subject>Synthesis</subject><subject>X-rays</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kU1LAzEQhhdRsFZ_gLcFz1snyTa7e6zFj0KtQvW8pNlJTWmTNUmR_ntTVyiikkPCzPNMXpgkuSQwIITl13MCBTDOKM2BAJRwlPQIhzJjbAjH8R3b2b5_mpx5v4I9xGkvmc13Jryh1z4VpkmfnW3RBY0-tSqd4Uc6tma1XYrQVSZeBG2-0Bstd3KtZfpojQ3oWjToz5MTJdYeL77vfvJ6d_syfsimT_eT8WiayZgnZCymxCYmzUXZUBAKVFmpvFlwUuaiKMhQ5hyVKskCKW0WoqLVgrJCVdFRULB-ctXNbZ1936IP9cpunYlf1gxYVZacFvxALcUaa22UDU7IjfayHhUV5DkMOYnU4A8qngY3WlqDSsf6D4F0gnTWe4eqbp3eCLerCdT7bdS_thEd2jk-smaJ7hD4f-kT9lCIyw</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Yarovaya, O. 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V.</creatorcontrib><creatorcontrib>Meshkova, Yu. V.</creatorcontrib><creatorcontrib>Marinina, M. K.</creatorcontrib><creatorcontrib>Oreshko, V. V.</creatorcontrib><creatorcontrib>Tolstikova, T. G.</creatorcontrib><creatorcontrib>Salakhutdinov, N. F.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yarovaya, O. I.</au><au>Baev, D. S.</au><au>Kovaleva, K. S.</au><au>Gatilov, Yu. V.</au><au>Meshkova, Yu. V.</au><au>Marinina, M. K.</au><au>Oreshko, V. V.</au><au>Tolstikova, T. G.</au><au>Salakhutdinov, N. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Properties of New Conjugates of Isatin and Bicyclic Monoterpenes</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2024</date><risdate>2024</risdate><volume>94</volume><issue>1</issue><spage>81</spage><epage>92</epage><pages>81-92</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>Conjugates of isatin and hydrazones based on (+)-camphor and (–)-fenchone were synthesized for the first time. The physicochemical properties of the synthesized compounds have been studied, and for the hydrazone product of fenchone and isatin X-ray diffraction data have been obtained. Molecular modeling of the possible interaction of new compounds with the active site of the basic protease 3CLpro of the SARS-CoV-2 virus was carried out, and the properties of isatin-terpene compounds as inhibitors of the 3CLpro protease were studied. It was found that the new conjugates do not exhibit inhibitory properties against 3CLpro, which makes it possible to clarify the direction of further chemical modifications of monoterpenoid derivatives in order to obtain molecules with antiviral properties.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363224010080</doi><tpages>12</tpages></addata></record> |
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| subjects | Amino acids Antiviral agents Camphor Chemistry Chemistry and Materials Science Chemistry/Food Science Conjugates Diffraction Health aspects Hydrazones Marburg virus disease Protease Protease inhibitors Proteases Synthesis X-rays |
| title | Synthesis and Properties of New Conjugates of Isatin and Bicyclic Monoterpenes |
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