Targeted Degradation of Cell‐Surface Proteins via Chaperone‐Mediated Autophagy by Using Peptide‐Conjugated Antibodies

Cell‐surface proteins are important drug targets but historically have posed big challenges for the complete elimination of their functions. Herein, we report antibody–peptide conjugates (Ab‐CMAs) in which a peptide targeting chaperone‐mediated autophagy (CMA) was conjugated with commercially availa...

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Veröffentlicht in:	Angewandte Chemie 2024-04, Vol.136 (18), p.n/a
Hauptverfasser:	Shao, Jinning, Lin, Xuefen, Wang, Haoting, Zhao, Chuhan, Yao, Shao Q., Ge, Jingyan, Zeng, Su, Qian, Linghui
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody–Peptide Conjugates Apoptosis Autophagy Biodegradation Biomedical materials Cell death Cell surface Cell-Surface Proteins Chaperone-Mediated Autophagy Degradation Epidermal growth factor Epidermal growth factor receptors ErbB-2 protein Growth factors Lysosomal Degradation Lysosomes Medical research Monoclonal antibodies PD-L1 protein Peptides Photodegradation Proteins Receptors Targeted Protein Degradation Therapeutic applications Therapeutic targets Ubiquitin-protein ligase
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