The diagnostic efficacy of diffusion tensor imaging in children with chronic kidney disease: correlation with histopathology and serum biomarkers
Background Children with chronic kidney disease (CKD) usually present with disease impact on growth besides cardiovascular problems that not only impact the patient's health during childhood but also affect their adult life. We aimed to identify the diagnostic role of diffusion tensor imaging (...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2024-12, Vol.55 (1), p.78-8, Article 78 |
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| creator | Mansour, Manar Elmokadem, Ali H. Elrazek, Ahmed A. Abd Hammad, Ayman Abd-Almoaty, Marwa R. Ali, Khadiga M. Ibrahim, Dina Abdalla Barakat, Tarek Elsayed |
| description | Background
Children with chronic kidney disease (CKD) usually present with disease impact on growth besides cardiovascular problems that not only impact the patient's health during childhood but also affect their adult life. We aimed to identify the diagnostic role of diffusion tensor imaging (DTI) in CKD in pediatric using its metrics: apparent diffusion coefficient (ADC) and fraction anisotropy (FA).
Results
This prospective study was performed on thirty-five CKD patients (16 girls, 19 boys; mean age 12.3 ± 2.6 years) and 19 sex- and age-matched controls. Both groups underwent renal DTI and renal function tests. Based on renal biopsy, patients with CKD were further categorized into sclerotic CKD (
n
= 25) and non-sclerotic CKD (
n
= 10). Mean FA renal medulla/cortex in CKD (0.18 ± 0.18 and 0.20 ± 0.17) was lower significantly (
p
= 0.001) than volunteers' (0.31 ± 0.19, 0.27 ± 0.18). The cutoff FA of renal medulla/cortex used for CKD diagnosis was 0.22 and 0.23 with AUC of 0.828, 0.838 and accuracy of 80.8%, 82.8%. Mean of renal medulla/cortex ADC in CKD (2.13 ± 0.23 and 1.93 ± 0.22 × 10
−3
mm
2
/s) was higher significantly (
p
= 0.001) than that of volunteers' (1.67 ± 0.15 and 1.64 ± 0.133 × 10
−3
mm
2
/s. ADC cutoff value of renal medulla/cortex used for CKD diagnosis was 1.86 and 1.74 × 10
−3
mm
2
/s with AUC of 0.827, 0.82, 0.827, and 0.911, and accuracy of 80.6%, 79.6%, 82.8%, and 84.2%. Renal medulla/cortex FA in sclerotic CKD was significantly different (
p
= 0.001) from non-sclerotic CKD (0.25 ± 0.07 and 0.26 ± 0.08). Cortical and medullary FA in CKD patients correlated with e-GFR (
r
= 0.363,
r
= 0.317) and serum creatinine (
r
= − 0.467,
r
= − 0.383).
Conclusions
Renal cortical/medullary FA can assist in diagnosing pediatric CKD, predict sclerotic CKD, and correlate with some serum biomarkers. |
| doi_str_mv | 10.1186/s43055-024-01250-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_proquest_journals_3035350658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A789691574</galeid><doaj_id>oai_doaj_org_article_839ea774139a406cbd05bccdccbe3554</doaj_id><sourcerecordid>A789691574</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-bec0cb89f9315ee5bdbbe5e20877f1da662a9922ef1ed8792e9c98eb5eda7e593</originalsourceid><addsrcrecordid>eNp9kstq3DAUhk1poSHJC3Ql6NqprrbVXQi9BALdpGuhy5GtiUeaSh6aeYy-cTTj0jRQKi0kHf7v5xzxN807gq8IGboPhTMsRIspbzGhArePr5oziiVued_R13_d3zaXpWxwXRxj0vGz5tf9BMgFPcZUlmAReB-stgeUfC17vy8hRbRALCmjsNVjiCMKEdkpzC5DRD_DMtVXTrHSD8FFOFSwgC7wEdmUM8x6OXqchFMoS9rpZUpzGg9IR4cK5P0WmZC2Oj9ALhfNG6_nApe_z_Pm--dP9zdf27tvX25vru9ay3m_tAYstmaQXjIiAIRxxoAAioe-98TprqNaSkrBE3BDLylIKwcwApzuQUh23tyuvi7pjdrlOlw-qKSDOhVSHpXO9UtmUAOToPueEyY1x501DgtjrbPWABOCV6_3q9cupx97KIvapH2OtX3FMBNM4E4Mz6pRV9MQfVqytttQrLruB9lJIvqj19U_VHU72AabIvhQ6y8AugI2p1Iy-D_DEKyOAVFrQFQNiDoFRD1WiK1QqeI4Qn7u-D_UE93xwVU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3035350658</pqid></control><display><type>article</type><title>The diagnostic efficacy of diffusion tensor imaging in children with chronic kidney disease: correlation with histopathology and serum biomarkers</title><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Mansour, Manar ; Elmokadem, Ali H. ; Elrazek, Ahmed A. Abd ; Hammad, Ayman ; Abd-Almoaty, Marwa R. ; Ali, Khadiga M. ; Ibrahim, Dina Abdalla ; Barakat, Tarek Elsayed</creator><creatorcontrib>Mansour, Manar ; Elmokadem, Ali H. ; Elrazek, Ahmed A. Abd ; Hammad, Ayman ; Abd-Almoaty, Marwa R. ; Ali, Khadiga M. ; Ibrahim, Dina Abdalla ; Barakat, Tarek Elsayed</creatorcontrib><description>Background
Children with chronic kidney disease (CKD) usually present with disease impact on growth besides cardiovascular problems that not only impact the patient's health during childhood but also affect their adult life. We aimed to identify the diagnostic role of diffusion tensor imaging (DTI) in CKD in pediatric using its metrics: apparent diffusion coefficient (ADC) and fraction anisotropy (FA).
Results
This prospective study was performed on thirty-five CKD patients (16 girls, 19 boys; mean age 12.3 ± 2.6 years) and 19 sex- and age-matched controls. Both groups underwent renal DTI and renal function tests. Based on renal biopsy, patients with CKD were further categorized into sclerotic CKD (
n
= 25) and non-sclerotic CKD (
n
= 10). Mean FA renal medulla/cortex in CKD (0.18 ± 0.18 and 0.20 ± 0.17) was lower significantly (
p
= 0.001) than volunteers' (0.31 ± 0.19, 0.27 ± 0.18). The cutoff FA of renal medulla/cortex used for CKD diagnosis was 0.22 and 0.23 with AUC of 0.828, 0.838 and accuracy of 80.8%, 82.8%. Mean of renal medulla/cortex ADC in CKD (2.13 ± 0.23 and 1.93 ± 0.22 × 10
−3
mm
2
/s) was higher significantly (
p
= 0.001) than that of volunteers' (1.67 ± 0.15 and 1.64 ± 0.133 × 10
−3
mm
2
/s. ADC cutoff value of renal medulla/cortex used for CKD diagnosis was 1.86 and 1.74 × 10
−3
mm
2
/s with AUC of 0.827, 0.82, 0.827, and 0.911, and accuracy of 80.6%, 79.6%, 82.8%, and 84.2%. Renal medulla/cortex FA in sclerotic CKD was significantly different (
p
= 0.001) from non-sclerotic CKD (0.25 ± 0.07 and 0.26 ± 0.08). Cortical and medullary FA in CKD patients correlated with e-GFR (
r
= 0.363,
r
= 0.317) and serum creatinine (
r
= − 0.467,
r
= − 0.383).
Conclusions
Renal cortical/medullary FA can assist in diagnosing pediatric CKD, predict sclerotic CKD, and correlate with some serum biomarkers.</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-024-01250-x</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Agreements ; Anisotropy ; Biological markers ; Biomarkers ; Biopsy ; Children ; Chronic kidney disease ; Chronic kidney failure ; Creatinine ; Diagnostic imaging ; Diffusion tensor imaging ; Glomerulosclerosis ; Histochemistry ; Imaging ; Interventional Radiology ; Kidney diseases ; Localization ; Lupus ; Medicine ; Medicine & Public Health ; Morphology ; MRI ; Nuclear Medicine ; Pediatric ; Pediatrics ; Radiology ; Software ; Statistical analysis</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2024-12, Vol.55 (1), p.78-8, Article 78</ispartof><rights>The Author(s) 2024</rights><rights>COPYRIGHT 2024 Springer</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c447t-bec0cb89f9315ee5bdbbe5e20877f1da662a9922ef1ed8792e9c98eb5eda7e593</cites><orcidid>0000-0001-5119-9548</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids></links><search><creatorcontrib>Mansour, Manar</creatorcontrib><creatorcontrib>Elmokadem, Ali H.</creatorcontrib><creatorcontrib>Elrazek, Ahmed A. Abd</creatorcontrib><creatorcontrib>Hammad, Ayman</creatorcontrib><creatorcontrib>Abd-Almoaty, Marwa R.</creatorcontrib><creatorcontrib>Ali, Khadiga M.</creatorcontrib><creatorcontrib>Ibrahim, Dina Abdalla</creatorcontrib><creatorcontrib>Barakat, Tarek Elsayed</creatorcontrib><title>The diagnostic efficacy of diffusion tensor imaging in children with chronic kidney disease: correlation with histopathology and serum biomarkers</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
Children with chronic kidney disease (CKD) usually present with disease impact on growth besides cardiovascular problems that not only impact the patient's health during childhood but also affect their adult life. We aimed to identify the diagnostic role of diffusion tensor imaging (DTI) in CKD in pediatric using its metrics: apparent diffusion coefficient (ADC) and fraction anisotropy (FA).
Results
This prospective study was performed on thirty-five CKD patients (16 girls, 19 boys; mean age 12.3 ± 2.6 years) and 19 sex- and age-matched controls. Both groups underwent renal DTI and renal function tests. Based on renal biopsy, patients with CKD were further categorized into sclerotic CKD (
n
= 25) and non-sclerotic CKD (
n
= 10). Mean FA renal medulla/cortex in CKD (0.18 ± 0.18 and 0.20 ± 0.17) was lower significantly (
p
= 0.001) than volunteers' (0.31 ± 0.19, 0.27 ± 0.18). The cutoff FA of renal medulla/cortex used for CKD diagnosis was 0.22 and 0.23 with AUC of 0.828, 0.838 and accuracy of 80.8%, 82.8%. Mean of renal medulla/cortex ADC in CKD (2.13 ± 0.23 and 1.93 ± 0.22 × 10
−3
mm
2
/s) was higher significantly (
p
= 0.001) than that of volunteers' (1.67 ± 0.15 and 1.64 ± 0.133 × 10
−3
mm
2
/s. ADC cutoff value of renal medulla/cortex used for CKD diagnosis was 1.86 and 1.74 × 10
−3
mm
2
/s with AUC of 0.827, 0.82, 0.827, and 0.911, and accuracy of 80.6%, 79.6%, 82.8%, and 84.2%. Renal medulla/cortex FA in sclerotic CKD was significantly different (
p
= 0.001) from non-sclerotic CKD (0.25 ± 0.07 and 0.26 ± 0.08). Cortical and medullary FA in CKD patients correlated with e-GFR (
r
= 0.363,
r
= 0.317) and serum creatinine (
r
= − 0.467,
r
= − 0.383).
Conclusions
Renal cortical/medullary FA can assist in diagnosing pediatric CKD, predict sclerotic CKD, and correlate with some serum biomarkers.</description><subject>Agreements</subject><subject>Anisotropy</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Children</subject><subject>Chronic kidney disease</subject><subject>Chronic kidney failure</subject><subject>Creatinine</subject><subject>Diagnostic imaging</subject><subject>Diffusion tensor imaging</subject><subject>Glomerulosclerosis</subject><subject>Histochemistry</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Kidney diseases</subject><subject>Localization</subject><subject>Lupus</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphology</subject><subject>MRI</subject><subject>Nuclear Medicine</subject><subject>Pediatric</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Software</subject><subject>Statistical analysis</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstq3DAUhk1poSHJC3Ql6NqprrbVXQi9BALdpGuhy5GtiUeaSh6aeYy-cTTj0jRQKi0kHf7v5xzxN807gq8IGboPhTMsRIspbzGhArePr5oziiVued_R13_d3zaXpWxwXRxj0vGz5tf9BMgFPcZUlmAReB-stgeUfC17vy8hRbRALCmjsNVjiCMKEdkpzC5DRD_DMtVXTrHSD8FFOFSwgC7wEdmUM8x6OXqchFMoS9rpZUpzGg9IR4cK5P0WmZC2Oj9ALhfNG6_nApe_z_Pm--dP9zdf27tvX25vru9ay3m_tAYstmaQXjIiAIRxxoAAioe-98TprqNaSkrBE3BDLylIKwcwApzuQUh23tyuvi7pjdrlOlw-qKSDOhVSHpXO9UtmUAOToPueEyY1x501DgtjrbPWABOCV6_3q9cupx97KIvapH2OtX3FMBNM4E4Mz6pRV9MQfVqytttQrLruB9lJIvqj19U_VHU72AabIvhQ6y8AugI2p1Iy-D_DEKyOAVFrQFQNiDoFRD1WiK1QqeI4Qn7u-D_UE93xwVU</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Mansour, Manar</creator><creator>Elmokadem, Ali H.</creator><creator>Elrazek, Ahmed A. Abd</creator><creator>Hammad, Ayman</creator><creator>Abd-Almoaty, Marwa R.</creator><creator>Ali, Khadiga M.</creator><creator>Ibrahim, Dina Abdalla</creator><creator>Barakat, Tarek Elsayed</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5119-9548</orcidid></search><sort><creationdate>20241201</creationdate><title>The diagnostic efficacy of diffusion tensor imaging in children with chronic kidney disease: correlation with histopathology and serum biomarkers</title><author>Mansour, Manar ; Elmokadem, Ali H. ; Elrazek, Ahmed A. Abd ; Hammad, Ayman ; Abd-Almoaty, Marwa R. ; Ali, Khadiga M. ; Ibrahim, Dina Abdalla ; Barakat, Tarek Elsayed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-bec0cb89f9315ee5bdbbe5e20877f1da662a9922ef1ed8792e9c98eb5eda7e593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Agreements</topic><topic>Anisotropy</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Children</topic><topic>Chronic kidney disease</topic><topic>Chronic kidney failure</topic><topic>Creatinine</topic><topic>Diagnostic imaging</topic><topic>Diffusion tensor imaging</topic><topic>Glomerulosclerosis</topic><topic>Histochemistry</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Kidney diseases</topic><topic>Localization</topic><topic>Lupus</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphology</topic><topic>MRI</topic><topic>Nuclear Medicine</topic><topic>Pediatric</topic><topic>Pediatrics</topic><topic>Radiology</topic><topic>Software</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mansour, Manar</creatorcontrib><creatorcontrib>Elmokadem, Ali H.</creatorcontrib><creatorcontrib>Elrazek, Ahmed A. Abd</creatorcontrib><creatorcontrib>Hammad, Ayman</creatorcontrib><creatorcontrib>Abd-Almoaty, Marwa R.</creatorcontrib><creatorcontrib>Ali, Khadiga M.</creatorcontrib><creatorcontrib>Ibrahim, Dina Abdalla</creatorcontrib><creatorcontrib>Barakat, Tarek Elsayed</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mansour, Manar</au><au>Elmokadem, Ali H.</au><au>Elrazek, Ahmed A. Abd</au><au>Hammad, Ayman</au><au>Abd-Almoaty, Marwa R.</au><au>Ali, Khadiga M.</au><au>Ibrahim, Dina Abdalla</au><au>Barakat, Tarek Elsayed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The diagnostic efficacy of diffusion tensor imaging in children with chronic kidney disease: correlation with histopathology and serum biomarkers</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2024-12-01</date><risdate>2024</risdate><volume>55</volume><issue>1</issue><spage>78</spage><epage>8</epage><pages>78-8</pages><artnum>78</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
Children with chronic kidney disease (CKD) usually present with disease impact on growth besides cardiovascular problems that not only impact the patient's health during childhood but also affect their adult life. We aimed to identify the diagnostic role of diffusion tensor imaging (DTI) in CKD in pediatric using its metrics: apparent diffusion coefficient (ADC) and fraction anisotropy (FA).
Results
This prospective study was performed on thirty-five CKD patients (16 girls, 19 boys; mean age 12.3 ± 2.6 years) and 19 sex- and age-matched controls. Both groups underwent renal DTI and renal function tests. Based on renal biopsy, patients with CKD were further categorized into sclerotic CKD (
n
= 25) and non-sclerotic CKD (
n
= 10). Mean FA renal medulla/cortex in CKD (0.18 ± 0.18 and 0.20 ± 0.17) was lower significantly (
p
= 0.001) than volunteers' (0.31 ± 0.19, 0.27 ± 0.18). The cutoff FA of renal medulla/cortex used for CKD diagnosis was 0.22 and 0.23 with AUC of 0.828, 0.838 and accuracy of 80.8%, 82.8%. Mean of renal medulla/cortex ADC in CKD (2.13 ± 0.23 and 1.93 ± 0.22 × 10
−3
mm
2
/s) was higher significantly (
p
= 0.001) than that of volunteers' (1.67 ± 0.15 and 1.64 ± 0.133 × 10
−3
mm
2
/s. ADC cutoff value of renal medulla/cortex used for CKD diagnosis was 1.86 and 1.74 × 10
−3
mm
2
/s with AUC of 0.827, 0.82, 0.827, and 0.911, and accuracy of 80.6%, 79.6%, 82.8%, and 84.2%. Renal medulla/cortex FA in sclerotic CKD was significantly different (
p
= 0.001) from non-sclerotic CKD (0.25 ± 0.07 and 0.26 ± 0.08). Cortical and medullary FA in CKD patients correlated with e-GFR (
r
= 0.363,
r
= 0.317) and serum creatinine (
r
= − 0.467,
r
= − 0.383).
Conclusions
Renal cortical/medullary FA can assist in diagnosing pediatric CKD, predict sclerotic CKD, and correlate with some serum biomarkers.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-024-01250-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5119-9548</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Agreements Anisotropy Biological markers Biomarkers Biopsy Children Chronic kidney disease Chronic kidney failure Creatinine Diagnostic imaging Diffusion tensor imaging Glomerulosclerosis Histochemistry Imaging Interventional Radiology Kidney diseases Localization Lupus Medicine Medicine & Public Health Morphology MRI Nuclear Medicine Pediatric Pediatrics Radiology Software Statistical analysis |
| title | The diagnostic efficacy of diffusion tensor imaging in children with chronic kidney disease: correlation with histopathology and serum biomarkers |
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