Breast edema score at breast MRI: its value in prediction of molecular subtype of breast cancer and its impact on axillary LN metastasis
Background Since many newly diagnosed breast cancer patients have breast MRI, the value of preoperative breast magnetic resonance imaging would improve if molecular subtypes could be consistently identified, and prognostic information provided in addition to diagnostic imaging. Breast edema may impr...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2024-04, Vol.55 (1), p.76-11, Article 76 |
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| creator | Abdelbary, Ebtsam Ahmed Mohammed Ibrahim, Amal Rayan Rezk, Khalid Mohammad Omar, Nagham Nabil |
| description | Background
Since many newly diagnosed breast cancer patients have breast MRI, the value of preoperative breast magnetic resonance imaging would improve if molecular subtypes could be consistently identified, and prognostic information provided in addition to diagnostic imaging. Breast edema may improve the ability to predict molecular subtypes and clinical and pathological outcomes in invasive breast cancer patients. The prognosis for breast cancer prognosis based on the findings of breast edema by magnetic resonance imaging will be useful in both pretreatment planning and prognosis. Breast edema on T2-weighted images and STIR was scored on a scale of 1 to 4, as follows: (a) breast edema score (BES) 1, no edema; (b) BES 2, peritumoral edema; (c) BES 3, pre pectoral edema; and (d) BES 4, subcutaneous edema (suspicious for occult inflammatory breast cancer “IBC”). Axillary lymph node status and number were also evaluated in T2 and STIR and after contrast administration. The aim of this work was to assess the role of tumour-related breast edema MRI features in distinguishing molecular subtypes of breast cancer and its effect on pathological axillary lymph nodes in patients with breast cancer.
Results
There was a highly significant difference between BES with respect to the molecular subtypes of breast cancer, size of the mass, Ki-67 expression, LN status, and LN number (
p
|
| doi_str_mv | 10.1186/s43055-024-01243-w |
| format | Article |
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Since many newly diagnosed breast cancer patients have breast MRI, the value of preoperative breast magnetic resonance imaging would improve if molecular subtypes could be consistently identified, and prognostic information provided in addition to diagnostic imaging. Breast edema may improve the ability to predict molecular subtypes and clinical and pathological outcomes in invasive breast cancer patients. The prognosis for breast cancer prognosis based on the findings of breast edema by magnetic resonance imaging will be useful in both pretreatment planning and prognosis. Breast edema on T2-weighted images and STIR was scored on a scale of 1 to 4, as follows: (a) breast edema score (BES) 1, no edema; (b) BES 2, peritumoral edema; (c) BES 3, pre pectoral edema; and (d) BES 4, subcutaneous edema (suspicious for occult inflammatory breast cancer “IBC”). Axillary lymph node status and number were also evaluated in T2 and STIR and after contrast administration. The aim of this work was to assess the role of tumour-related breast edema MRI features in distinguishing molecular subtypes of breast cancer and its effect on pathological axillary lymph nodes in patients with breast cancer.
Results
There was a highly significant difference between BES with respect to the molecular subtypes of breast cancer, size of the mass, Ki-67 expression, LN status, and LN number (
p
< 0.0001, 0.045, < 0.0001, < 0.0001, and < 0.0001 respectively). However, there was no significant difference between BES and histopathological grade in studied masses, such as
p
-value = 0.49.
Conclusions
Tumour-related breast edema MRI characteristics may be useful in distinguishing molecular subtypes of breast cancer and could be used as a promising feature to improve the predictive performance of pathological axillary lymph nodes in patients with breast cancer, contributing to preoperative treatment planning and prognostic outcome.</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-024-01243-w</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biopsy ; Breast cancer ; Breast edema ; Edema ; Epidermal growth factor ; Estrogens ; HER2 ; Imaging ; Interventional Radiology ; Luminal A ; Luminal B ; Lymphatic system ; Mastectomy ; Medical prognosis ; Medical records ; Medicine ; Medicine & Public Health ; Metastasis ; MRI ; Nuclear Medicine ; Patients ; Radiology ; Triple negative ; Tumors</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2024-04, Vol.55 (1), p.76-11, Article 76</ispartof><rights>The Author(s) 2024</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c380t-5f8cd497f1d3baa25f4d7838ad569f8576a8d9ae6ffd672d3372a34f8038eb763</cites><orcidid>0000-0002-8247-0502</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Abdelbary, Ebtsam Ahmed Mohammed</creatorcontrib><creatorcontrib>Ibrahim, Amal Rayan</creatorcontrib><creatorcontrib>Rezk, Khalid Mohammad</creatorcontrib><creatorcontrib>Omar, Nagham Nabil</creatorcontrib><title>Breast edema score at breast MRI: its value in prediction of molecular subtype of breast cancer and its impact on axillary LN metastasis</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
Since many newly diagnosed breast cancer patients have breast MRI, the value of preoperative breast magnetic resonance imaging would improve if molecular subtypes could be consistently identified, and prognostic information provided in addition to diagnostic imaging. Breast edema may improve the ability to predict molecular subtypes and clinical and pathological outcomes in invasive breast cancer patients. The prognosis for breast cancer prognosis based on the findings of breast edema by magnetic resonance imaging will be useful in both pretreatment planning and prognosis. Breast edema on T2-weighted images and STIR was scored on a scale of 1 to 4, as follows: (a) breast edema score (BES) 1, no edema; (b) BES 2, peritumoral edema; (c) BES 3, pre pectoral edema; and (d) BES 4, subcutaneous edema (suspicious for occult inflammatory breast cancer “IBC”). Axillary lymph node status and number were also evaluated in T2 and STIR and after contrast administration. The aim of this work was to assess the role of tumour-related breast edema MRI features in distinguishing molecular subtypes of breast cancer and its effect on pathological axillary lymph nodes in patients with breast cancer.
Results
There was a highly significant difference between BES with respect to the molecular subtypes of breast cancer, size of the mass, Ki-67 expression, LN status, and LN number (
p
< 0.0001, 0.045, < 0.0001, < 0.0001, and < 0.0001 respectively). However, there was no significant difference between BES and histopathological grade in studied masses, such as
p
-value = 0.49.
Conclusions
Tumour-related breast edema MRI characteristics may be useful in distinguishing molecular subtypes of breast cancer and could be used as a promising feature to improve the predictive performance of pathological axillary lymph nodes in patients with breast cancer, contributing to preoperative treatment planning and prognostic outcome.</description><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast edema</subject><subject>Edema</subject><subject>Epidermal growth factor</subject><subject>Estrogens</subject><subject>HER2</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Luminal A</subject><subject>Luminal B</subject><subject>Lymphatic system</subject><subject>Mastectomy</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>MRI</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Radiology</subject><subject>Triple negative</subject><subject>Tumors</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kcFu1TAQRSMEElXpD7CyxDpgx07ssIMKypMeVELt2prY48pPSRxsh7Z_0M_GfamgK7wZ6-qeOyPdqnrL6HvGVPchCU7btqaNqClrBK9vX1QnDe1pLWTXvHz2f12dpXSg5QlKWSdOqofPESFlghYnIMmEiAQyGTb1-8_dR-JzIr9hXJH4mSwRrTfZh5kER6YwollHiCStQ75f8FF8Yg3MBiOB2R4T_LSAyaRwcOfHgtyT_Q8yYS5eSD69qV45GBOePc3T6vrrl6vzb_X-8mJ3_mlfG65orlunjBW9dMzyAaBpnbBScQW27XqnWtmBsj1g55ztZGM5lw1w4RTlCgfZ8dNqt-XaAAe9RD-VU3QAr49CiDcaYvZmRC0pMzhYVMpQgUaoQXHLABTrm36gpmS927KWGH6tmLI-hDXO5XzNadks25bJ4mo2l4khpYju71ZG9WOBeitQlwL1sUB9WyC-QamY5xuM_6L_Q_0Bgamflw</recordid><startdate>20240405</startdate><enddate>20240405</enddate><creator>Abdelbary, Ebtsam Ahmed Mohammed</creator><creator>Ibrahim, Amal Rayan</creator><creator>Rezk, Khalid Mohammad</creator><creator>Omar, Nagham Nabil</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8247-0502</orcidid></search><sort><creationdate>20240405</creationdate><title>Breast edema score at breast MRI: its value in prediction of molecular subtype of breast cancer and its impact on axillary LN metastasis</title><author>Abdelbary, Ebtsam Ahmed Mohammed ; Ibrahim, Amal Rayan ; Rezk, Khalid Mohammad ; Omar, Nagham Nabil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-5f8cd497f1d3baa25f4d7838ad569f8576a8d9ae6ffd672d3372a34f8038eb763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast edema</topic><topic>Edema</topic><topic>Epidermal growth factor</topic><topic>Estrogens</topic><topic>HER2</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Luminal A</topic><topic>Luminal B</topic><topic>Lymphatic system</topic><topic>Mastectomy</topic><topic>Medical prognosis</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>MRI</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Radiology</topic><topic>Triple negative</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdelbary, Ebtsam Ahmed Mohammed</creatorcontrib><creatorcontrib>Ibrahim, Amal Rayan</creatorcontrib><creatorcontrib>Rezk, Khalid Mohammad</creatorcontrib><creatorcontrib>Omar, Nagham Nabil</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdelbary, Ebtsam Ahmed Mohammed</au><au>Ibrahim, Amal Rayan</au><au>Rezk, Khalid Mohammad</au><au>Omar, Nagham Nabil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breast edema score at breast MRI: its value in prediction of molecular subtype of breast cancer and its impact on axillary LN metastasis</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2024-04-05</date><risdate>2024</risdate><volume>55</volume><issue>1</issue><spage>76</spage><epage>11</epage><pages>76-11</pages><artnum>76</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
Since many newly diagnosed breast cancer patients have breast MRI, the value of preoperative breast magnetic resonance imaging would improve if molecular subtypes could be consistently identified, and prognostic information provided in addition to diagnostic imaging. Breast edema may improve the ability to predict molecular subtypes and clinical and pathological outcomes in invasive breast cancer patients. The prognosis for breast cancer prognosis based on the findings of breast edema by magnetic resonance imaging will be useful in both pretreatment planning and prognosis. Breast edema on T2-weighted images and STIR was scored on a scale of 1 to 4, as follows: (a) breast edema score (BES) 1, no edema; (b) BES 2, peritumoral edema; (c) BES 3, pre pectoral edema; and (d) BES 4, subcutaneous edema (suspicious for occult inflammatory breast cancer “IBC”). Axillary lymph node status and number were also evaluated in T2 and STIR and after contrast administration. The aim of this work was to assess the role of tumour-related breast edema MRI features in distinguishing molecular subtypes of breast cancer and its effect on pathological axillary lymph nodes in patients with breast cancer.
Results
There was a highly significant difference between BES with respect to the molecular subtypes of breast cancer, size of the mass, Ki-67 expression, LN status, and LN number (
p
< 0.0001, 0.045, < 0.0001, < 0.0001, and < 0.0001 respectively). However, there was no significant difference between BES and histopathological grade in studied masses, such as
p
-value = 0.49.
Conclusions
Tumour-related breast edema MRI characteristics may be useful in distinguishing molecular subtypes of breast cancer and could be used as a promising feature to improve the predictive performance of pathological axillary lymph nodes in patients with breast cancer, contributing to preoperative treatment planning and prognostic outcome.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-024-01243-w</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8247-0502</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biopsy Breast cancer Breast edema Edema Epidermal growth factor Estrogens HER2 Imaging Interventional Radiology Luminal A Luminal B Lymphatic system Mastectomy Medical prognosis Medical records Medicine Medicine & Public Health Metastasis MRI Nuclear Medicine Patients Radiology Triple negative Tumors |
| title | Breast edema score at breast MRI: its value in prediction of molecular subtype of breast cancer and its impact on axillary LN metastasis |
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