The ChAMP App: A Scalable mHealth Technology for Detecting Digital Phenotypes of Early Childhood Mental Health
Childhood mental health problems are common, impairing, and can become chronic if left untreated. Children are not reliable reporters of their emotional and behavioral health, and caregivers often unintentionally under- or over-report child symptoms, making assessment challenging. Objective physiolo...
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creator | Loftness, Bryn C. Halvorson-Phelan, Julia OLeary, Aisling Bradshaw, Carter Prytherch, Shania Berman, Isabel Torous, John Copeland, William L. Cheney, Nick McGinnis, Ryan S. McGinnis, Ellen W. |
description | Childhood mental health problems are common, impairing, and can become chronic if left untreated. Children are not reliable reporters of their emotional and behavioral health, and caregivers often unintentionally under- or over-report child symptoms, making assessment challenging. Objective physiological and behavioral measures of emotional and behavioral health are emerging. However, these methods typically require specialized equipment and expertise in data and sensor engineering to administer and analyze. To address this challenge, we have developed the ChAMP (Childhood Assessment and Management of digital Phenotypes) System, which includes a mobile application for collecting movement and audio data during a battery of mood induction tasks and an open-source platform for extracting digital biomarkers. As proof of principle, we present ChAMP System data from 101 children 4-8 years old, with and without diagnosed mental health disorders. Machine learning models trained on these data detect the presence of specific disorders with 70-73% balanced accuracy, with similar results to clinical thresholds on established parent-report measures (63-82% balanced accuracy). Features favored in model architectures are described using Shapley Additive Explanations (SHAP). Canonical Correlation Analysis reveals moderate to strong associations between predictors of each disorder and associated symptom severity (r = .51-.83). The open-source ChAMP System provides clinically-relevant digital biomarkers that may later complement parent-report measures of emotional and behavioral health for detecting kids with underlying mental health conditions and lowers the barrier to entry for researchers interested in exploring digital phenotyping of childhood mental health. |
doi_str_mv | 10.1109/JBHI.2023.3337649 |
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Children are not reliable reporters of their emotional and behavioral health, and caregivers often unintentionally under- or over-report child symptoms, making assessment challenging. Objective physiological and behavioral measures of emotional and behavioral health are emerging. However, these methods typically require specialized equipment and expertise in data and sensor engineering to administer and analyze. To address this challenge, we have developed the ChAMP (Childhood Assessment and Management of digital Phenotypes) System, which includes a mobile application for collecting movement and audio data during a battery of mood induction tasks and an open-source platform for extracting digital biomarkers. As proof of principle, we present ChAMP System data from 101 children 4-8 years old, with and without diagnosed mental health disorders. Machine learning models trained on these data detect the presence of specific disorders with 70-73% balanced accuracy, with similar results to clinical thresholds on established parent-report measures (63-82% balanced accuracy). Features favored in model architectures are described using Shapley Additive Explanations (SHAP). Canonical Correlation Analysis reveals moderate to strong associations between predictors of each disorder and associated symptom severity (r = .51-.83). The open-source ChAMP System provides clinically-relevant digital biomarkers that may later complement parent-report measures of emotional and behavioral health for detecting kids with underlying mental health conditions and lowers the barrier to entry for researchers interested in exploring digital phenotyping of childhood mental health.</description><identifier>ISSN: 2168-2194</identifier><identifier>EISSN: 2168-2208</identifier><identifier>DOI: 10.1109/JBHI.2023.3337649</identifier><identifier>PMID: 38019617</identifier><identifier>CODEN: IJBHA9</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Accuracy ; Additives ; adhd ; anxiety ; Anxiety disorders ; Applications programs ; Audio data ; Behavioral sciences ; Biomarkers ; Children ; Correlation analysis ; depression ; digital biomarkers ; digital health ; Disorders ; Emotional behavior ; Health problems ; Machine learning ; Mental disorders ; Mental health ; Mobile computing ; mobile health ; Mood ; Open source software ; Parents ; pediatric mental health ; Pediatrics ; Phenotypes ; Phenotyping ; Physiology ; Signs and symptoms ; Symptoms ; Task analysis</subject><ispartof>IEEE journal of biomedical and health informatics, 2024-04, Vol.PP (4), p.1-10</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. 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Children are not reliable reporters of their emotional and behavioral health, and caregivers often unintentionally under- or over-report child symptoms, making assessment challenging. Objective physiological and behavioral measures of emotional and behavioral health are emerging. However, these methods typically require specialized equipment and expertise in data and sensor engineering to administer and analyze. To address this challenge, we have developed the ChAMP (Childhood Assessment and Management of digital Phenotypes) System, which includes a mobile application for collecting movement and audio data during a battery of mood induction tasks and an open-source platform for extracting digital biomarkers. As proof of principle, we present ChAMP System data from 101 children 4-8 years old, with and without diagnosed mental health disorders. Machine learning models trained on these data detect the presence of specific disorders with 70-73% balanced accuracy, with similar results to clinical thresholds on established parent-report measures (63-82% balanced accuracy). Features favored in model architectures are described using Shapley Additive Explanations (SHAP). Canonical Correlation Analysis reveals moderate to strong associations between predictors of each disorder and associated symptom severity (r = .51-.83). The open-source ChAMP System provides clinically-relevant digital biomarkers that may later complement parent-report measures of emotional and behavioral health for detecting kids with underlying mental health conditions and lowers the barrier to entry for researchers interested in exploring digital phenotyping of childhood mental health.</description><subject>Accuracy</subject><subject>Additives</subject><subject>adhd</subject><subject>anxiety</subject><subject>Anxiety disorders</subject><subject>Applications programs</subject><subject>Audio data</subject><subject>Behavioral sciences</subject><subject>Biomarkers</subject><subject>Children</subject><subject>Correlation analysis</subject><subject>depression</subject><subject>digital biomarkers</subject><subject>digital health</subject><subject>Disorders</subject><subject>Emotional behavior</subject><subject>Health problems</subject><subject>Machine learning</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Mobile computing</subject><subject>mobile health</subject><subject>Mood</subject><subject>Open source software</subject><subject>Parents</subject><subject>pediatric mental health</subject><subject>Pediatrics</subject><subject>Phenotypes</subject><subject>Phenotyping</subject><subject>Physiology</subject><subject>Signs and symptoms</subject><subject>Symptoms</subject><subject>Task analysis</subject><issn>2168-2194</issn><issn>2168-2208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ESBDL</sourceid><sourceid>RIE</sourceid><recordid>eNpdkU1LAzEQhoMoKuoPEEQCXry05mM3m3ir9aNKi4L1HHazk-5Kulk320P_vSmtIuYyYXjmYZgXoXNKhpQSdfNyN3keMsL4kHOeiUTtoWNGhRwwRuT-z5-q5AidhfBJ4pOxpcQhOuKSUCVodoyaeQV4XI1mb3jUtrd4hN9N7vLCAV5OIHd9hedgqsY7v1hj6zt8Dz2Yvm4W-L5e1H3u8FsFje_XLQTsLX7IO7eOytqVlfclnkGzgbayU3RgcxfgbFdP0Mfjw3w8GUxfn57Ho-nAcMX7Ac2EKJmVRlFbJEpxlnKR0KKQLJPWQuwZkibClpDJghJhEqkYNSZliksg_ARdb71t579WEHq9rIMB5_IG_CpoJlWakVRkLKJX_9BPv-qauJ3mhHNBpZJJpOiWMp0PoQOr265e5t1aU6I3eehNHnqTh97lEWcud-ZVsYTyd-Ln-hG42AI1APwRRgETCf8GsIaMBQ</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Loftness, Bryn C.</creator><creator>Halvorson-Phelan, Julia</creator><creator>OLeary, Aisling</creator><creator>Bradshaw, Carter</creator><creator>Prytherch, Shania</creator><creator>Berman, Isabel</creator><creator>Torous, John</creator><creator>Copeland, William L.</creator><creator>Cheney, Nick</creator><creator>McGinnis, Ryan S.</creator><creator>McGinnis, Ellen W.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. 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Halvorson-Phelan, Julia ; OLeary, Aisling ; Bradshaw, Carter ; Prytherch, Shania ; Berman, Isabel ; Torous, John ; Copeland, William L. ; Cheney, Nick ; McGinnis, Ryan S. ; McGinnis, Ellen W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-1766d2f8c91fb4993253641bb8278ffeb49c0546fde78b106c48921cc52938e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Accuracy</topic><topic>Additives</topic><topic>adhd</topic><topic>anxiety</topic><topic>Anxiety disorders</topic><topic>Applications programs</topic><topic>Audio data</topic><topic>Behavioral sciences</topic><topic>Biomarkers</topic><topic>Children</topic><topic>Correlation analysis</topic><topic>depression</topic><topic>digital biomarkers</topic><topic>digital health</topic><topic>Disorders</topic><topic>Emotional behavior</topic><topic>Health problems</topic><topic>Machine learning</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Mobile computing</topic><topic>mobile health</topic><topic>Mood</topic><topic>Open source software</topic><topic>Parents</topic><topic>pediatric mental health</topic><topic>Pediatrics</topic><topic>Phenotypes</topic><topic>Phenotyping</topic><topic>Physiology</topic><topic>Signs and symptoms</topic><topic>Symptoms</topic><topic>Task analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loftness, Bryn C.</creatorcontrib><creatorcontrib>Halvorson-Phelan, Julia</creatorcontrib><creatorcontrib>OLeary, Aisling</creatorcontrib><creatorcontrib>Bradshaw, Carter</creatorcontrib><creatorcontrib>Prytherch, Shania</creatorcontrib><creatorcontrib>Berman, Isabel</creatorcontrib><creatorcontrib>Torous, John</creatorcontrib><creatorcontrib>Copeland, William L.</creatorcontrib><creatorcontrib>Cheney, Nick</creatorcontrib><creatorcontrib>McGinnis, Ryan S.</creatorcontrib><creatorcontrib>McGinnis, Ellen W.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE Open Access Journals</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>IEEE journal of biomedical and health informatics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loftness, Bryn C.</au><au>Halvorson-Phelan, Julia</au><au>OLeary, Aisling</au><au>Bradshaw, Carter</au><au>Prytherch, Shania</au><au>Berman, Isabel</au><au>Torous, John</au><au>Copeland, William L.</au><au>Cheney, Nick</au><au>McGinnis, Ryan S.</au><au>McGinnis, Ellen W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ChAMP App: A Scalable mHealth Technology for Detecting Digital Phenotypes of Early Childhood Mental Health</atitle><jtitle>IEEE journal of biomedical and health informatics</jtitle><stitle>JBHI</stitle><addtitle>IEEE J Biomed Health Inform</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>PP</volume><issue>4</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>2168-2194</issn><eissn>2168-2208</eissn><coden>IJBHA9</coden><abstract>Childhood mental health problems are common, impairing, and can become chronic if left untreated. Children are not reliable reporters of their emotional and behavioral health, and caregivers often unintentionally under- or over-report child symptoms, making assessment challenging. Objective physiological and behavioral measures of emotional and behavioral health are emerging. However, these methods typically require specialized equipment and expertise in data and sensor engineering to administer and analyze. To address this challenge, we have developed the ChAMP (Childhood Assessment and Management of digital Phenotypes) System, which includes a mobile application for collecting movement and audio data during a battery of mood induction tasks and an open-source platform for extracting digital biomarkers. As proof of principle, we present ChAMP System data from 101 children 4-8 years old, with and without diagnosed mental health disorders. Machine learning models trained on these data detect the presence of specific disorders with 70-73% balanced accuracy, with similar results to clinical thresholds on established parent-report measures (63-82% balanced accuracy). Features favored in model architectures are described using Shapley Additive Explanations (SHAP). Canonical Correlation Analysis reveals moderate to strong associations between predictors of each disorder and associated symptom severity (r = .51-.83). 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subjects | Accuracy Additives adhd anxiety Anxiety disorders Applications programs Audio data Behavioral sciences Biomarkers Children Correlation analysis depression digital biomarkers digital health Disorders Emotional behavior Health problems Machine learning Mental disorders Mental health Mobile computing mobile health Mood Open source software Parents pediatric mental health Pediatrics Phenotypes Phenotyping Physiology Signs and symptoms Symptoms Task analysis |
title | The ChAMP App: A Scalable mHealth Technology for Detecting Digital Phenotypes of Early Childhood Mental Health |
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