The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma

Virtually all patients with BRAF-mutant melanoma develop resistance to MAPK inhibitors largely through nonmutational events. Although the epigenetic landscape is shown to be altered in therapy-resistant melanomas and other cancers, a specific targetable epigenetic mechanism has not been validated. H...

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Veröffentlicht in:	The Journal of clinical investigation 2024-03, Vol.134 (6), p.1-21
Hauptverfasser:	Wu, Muzhou, Hanly, Ailish, Gibson, Frederick, Fisher, Robert, Rogers, Samantha, Park, Kihyun, Zuger, Angelina, Kuang, Kevin, Kalin, Jay H, Nocco, Sarah, Cole, Matthew, Xiao, Amy, Agus, Filisia, Labadorf, Adam, Beck, Samuel, Collard, Marianne, Cole, Philip A, Alani, Rhoda M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Care and treatment Cell growth Chromatin Development and progression DNA binding proteins Drug resistance Epigenetic inheritance Epigenetics Genes Genetic aspects Genotype & phenotype Health aspects Histones Melanoma Ontology Phenotypes Phenotypic plasticity Phosphatase Phosphatases Physiological aspects Scientific equipment and supplies industry Stem cells Transcription factors Vemurafenib
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