In Utero Exposure to Lead is Associated with Neural Tube Defects via Disturbing the Expression of Endocannabinoid Retrograde Signaling-Related Genes

Neural tube defects (NTDs) are a group of severe congenital malformations of the central nervous system, for which environmental causes are not fully known. In a human case–control study, we compared lead (Pb) levels in umbilical cord blood serum from 40 NTD cases and 119 controls. In a toxicology s...

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Veröffentlicht in:	Exposure and health 2024-04, Vol.16 (2), p.431-444
Hauptverfasser:	Tian, Tian, Dong, Huijun, Yin, Shengju, Liu, Mengyuan, Chen, Yongyan, Xiang, Kuanhui, Wang, Linlin, Qiao, Jie, Ren, Aiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amniotic fluid Aquatic Pollution Birth defects Cell differentiation Central nervous system Congenital defects Cord blood Defects Differentiation (biology) Earth and Environmental Science Embryo cells Embryos Environment Environmental Health Females Fetuses Gas flow Gene expression Gene sequencing Genes Health care Heavy metals Intrauterine exposure Lead Lead acetates Medical research Nervous system Neural tube defects Original Paper Pollution Pregnancy Prenatal exposure Public health Retrograde transport Ribonucleic acid RNA siRNA Spina bifida Stem cells Toxicology Umbilical cord Vitamin B Waste Water Technology Water and Health Water Management Water Pollution Control Water Quality/Water Pollution
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