Synthesis of tricyclic pyrazolopyrimidine arylidene ester derivatives and their cytotoxic and molecular docking evaluations

Our research team has synthesized 33 tricyclic pyrazolopyrimidine arylidene ester derivatives using the lead compound CAM551 as a starting point. This was achieved by a designed five‐step synthesis strategy. The synthesized compounds' inhibitory activities against HT‐116 human colorectal adenoc...

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Veröffentlicht in:	Journal of heterocyclic chemistry 2024-04, Vol.61 (4), p.651-668
Hauptverfasser:	Lu, Tong, Nie, Lifei, Tang, Dan, Bozorov, Khurshed, Zhao, Jiangyu, Aisa, Haji Akber
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Lead compounds Molecular docking Pyrazolopyrimidines
Online-Zugang:	Volltext
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