Hydrogels Based on Gellan and a Graft Copolymer of Pullulan with Poly(2-methyl-2-oxazoline) Side Groups

In this work, a three-component system is obtained based on gellan, a graft copolymer of pullulan with side chains of poly(2-methyl-2-oxazoline), and CaCl 2 , which is capable of forming gels upon contact with an aqueous solution of NaCl. Such a composition can be used for medical purposes, in parti...

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Veröffentlicht in:Nanobiotechnology Reports (Online) 2023-12, Vol.18 (Suppl 2), p.S345-S351
Hauptverfasser: Lezov, A. A., Rogozhin, V. B., Lezova, A. A., Mikusheva, N. G., Perevyazko, I. Yu, Polushina, G. E., Gubarev, A. S., Zorin, I. M., Tsvetkov, N. V.
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container_end_page S351
container_issue Suppl 2
container_start_page S345
container_title Nanobiotechnology Reports (Online)
container_volume 18
creator Lezov, A. A.
Rogozhin, V. B.
Lezova, A. A.
Mikusheva, N. G.
Perevyazko, I. Yu
Polushina, G. E.
Gubarev, A. S.
Zorin, I. M.
Tsvetkov, N. V.
description In this work, a three-component system is obtained based on gellan, a graft copolymer of pullulan with side chains of poly(2-methyl-2-oxazoline), and CaCl 2 , which is capable of forming gels upon contact with an aqueous solution of NaCl. Such a composition can be used for medical purposes, in particular for the treatment of ophthalmological diseases. In this work, the molecular characteristics of the initial components of the gel are obtained and its viscoelastic properties are studied. It was established that graft copolymers of pullulan with poly(2-methyl-2-oxazoline) are integrated into the gel composition, while an increase in their proportion reduces its elastic properties. The obtained gel retain elastic properties upon heating up to 70°C.
doi_str_mv 10.1134/S2635167623601481
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ispartof Nanobiotechnology Reports (Online), 2023-12, Vol.18 (Suppl 2), p.S345-S351
issn 2635-1676
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language eng
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subjects Aqueous solutions
Bioorganic
Calcium chloride
Chemistry and Materials Science
Composition
Elastic properties
Graft copolymers
Hybrid Nanomaterials
Industrial and Production Engineering
Machines
Manufacturing
Materials Science
Nanotechnology
Polymer
Processes
Pullulan
title Hydrogels Based on Gellan and a Graft Copolymer of Pullulan with Poly(2-methyl-2-oxazoline) Side Groups
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