The Effects of Vitamin C on Wound Healing—Systematic Review
Vitamin C may have positive effects on wound healing and improve quality of life and the recovery process. A systematic review was done to study the effects of vitamin C on the healing of wounds and thereby hasten rehabilitation. Randomized controlled trials (RCTs) and controlled clinical trials on...
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| Veröffentlicht in: | Indian journal of surgery 2024-02, Vol.86 (1), p.23-29 |
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| creator | Thevi, Thanigasalam Abas, Adinegara Lutfi Rajan, Mohan |
| description | Vitamin C may have positive effects on wound healing and improve quality of life and the recovery process. A systematic review was done to study the effects of vitamin C on the healing of wounds and thereby hasten rehabilitation. Randomized controlled trials (RCTs) and controlled clinical trials on the effects of vitamin C were searched for using PubMed, Google Scholar, Science Direct, and Cochrane Library. Data was collected, analyzed, and assessed for risks of bias using Cochrane review protocols and tools. A total of 24 trials were procured, but after excluding 21 that did not meet the criteria, only three trials could be analyzed. Overall, addition of vitamin C was noted to have 3.94 times likelihood of acquiring quicker recovery process as compared to placebo (OR 3.99, 95% CI 2.06 to 7.73), but there was no difference in pain (
p
> 0.05). Overall quality of evidence was good, with low risk of bias. Evidence shows that vitamin C promotes wound healing by hastening recovery and attaining high leucocyte ascorbic acid levels. It is recommended to use vitamin C for wound healing while waiting for more RCTs to strengthen this evidence. |
| doi_str_mv | 10.1007/s12262-023-03750-y |
| format | Article |
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p
> 0.05). Overall quality of evidence was good, with low risk of bias. Evidence shows that vitamin C promotes wound healing by hastening recovery and attaining high leucocyte ascorbic acid levels. It is recommended to use vitamin C for wound healing while waiting for more RCTs to strengthen this evidence.</description><identifier>ISSN: 0972-2068</identifier><identifier>EISSN: 0973-9793</identifier><identifier>DOI: 10.1007/s12262-023-03750-y</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Cardiac Surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Pediatric Surgery ; Plastic Surgery ; Review Article ; Surgery ; Systematic review ; Thoracic Surgery ; Vitamin C ; Wound healing</subject><ispartof>Indian journal of surgery, 2024-02, Vol.86 (1), p.23-29</ispartof><rights>Association of Surgeons of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-737ff1d2e1f577c8d75d07725def0b0e40654cadd12d2afd56c6deaa827ada5b3</citedby><cites>FETCH-LOGICAL-c319t-737ff1d2e1f577c8d75d07725def0b0e40654cadd12d2afd56c6deaa827ada5b3</cites><orcidid>0000-0002-9317-475X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12262-023-03750-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12262-023-03750-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Thevi, Thanigasalam</creatorcontrib><creatorcontrib>Abas, Adinegara Lutfi</creatorcontrib><creatorcontrib>Rajan, Mohan</creatorcontrib><title>The Effects of Vitamin C on Wound Healing—Systematic Review</title><title>Indian journal of surgery</title><addtitle>Indian J Surg</addtitle><description>Vitamin C may have positive effects on wound healing and improve quality of life and the recovery process. A systematic review was done to study the effects of vitamin C on the healing of wounds and thereby hasten rehabilitation. Randomized controlled trials (RCTs) and controlled clinical trials on the effects of vitamin C were searched for using PubMed, Google Scholar, Science Direct, and Cochrane Library. Data was collected, analyzed, and assessed for risks of bias using Cochrane review protocols and tools. A total of 24 trials were procured, but after excluding 21 that did not meet the criteria, only three trials could be analyzed. Overall, addition of vitamin C was noted to have 3.94 times likelihood of acquiring quicker recovery process as compared to placebo (OR 3.99, 95% CI 2.06 to 7.73), but there was no difference in pain (
p
> 0.05). Overall quality of evidence was good, with low risk of bias. Evidence shows that vitamin C promotes wound healing by hastening recovery and attaining high leucocyte ascorbic acid levels. It is recommended to use vitamin C for wound healing while waiting for more RCTs to strengthen this evidence.</description><subject>Cardiac Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Pediatric Surgery</subject><subject>Plastic Surgery</subject><subject>Review Article</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Thoracic Surgery</subject><subject>Vitamin C</subject><subject>Wound healing</subject><issn>0972-2068</issn><issn>0973-9793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kLFOwzAQhi0EEqXwAkyWmA1nO46TgQFVhSJVQoICo-Xa55KqTUqcgrLxEDwhT0JokNiY7ob_-0_3EXLK4ZwD6IvIhUgFAyEZSK2AtXtkALmWLNe53N_tgglIs0NyFOMSQCSplANyOXtBOg4BXRNpFehT0dh1UdIRrUr6XG1LTydoV0W5-Pr4fGhjg2vbFI7e41uB78fkINhVxJPfOSSP1-PZaMKmdze3o6spc5LnDdNSh8C9QB6U1i7zWnnQWiiPAeaACaQqcdZ7LrywwavUpR6tzYS23qq5HJKzvndTV69bjI1ZVtu67E4a0T3Jk4TzvEuJPuXqKsYag9nUxdrWreFgfjSZXpPpNJmdJtN2kOyh2IXLBdZ_1f9Q31mra7w</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Thevi, Thanigasalam</creator><creator>Abas, Adinegara Lutfi</creator><creator>Rajan, Mohan</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-9317-475X</orcidid></search><sort><creationdate>20240201</creationdate><title>The Effects of Vitamin C on Wound Healing—Systematic Review</title><author>Thevi, Thanigasalam ; Abas, Adinegara Lutfi ; Rajan, Mohan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-737ff1d2e1f577c8d75d07725def0b0e40654cadd12d2afd56c6deaa827ada5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiac Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Pediatric Surgery</topic><topic>Plastic Surgery</topic><topic>Review Article</topic><topic>Surgery</topic><topic>Systematic review</topic><topic>Thoracic Surgery</topic><topic>Vitamin C</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thevi, Thanigasalam</creatorcontrib><creatorcontrib>Abas, Adinegara Lutfi</creatorcontrib><creatorcontrib>Rajan, Mohan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Indian journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thevi, Thanigasalam</au><au>Abas, Adinegara Lutfi</au><au>Rajan, Mohan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Vitamin C on Wound Healing—Systematic Review</atitle><jtitle>Indian journal of surgery</jtitle><stitle>Indian J Surg</stitle><date>2024-02-01</date><risdate>2024</risdate><volume>86</volume><issue>1</issue><spage>23</spage><epage>29</epage><pages>23-29</pages><issn>0972-2068</issn><eissn>0973-9793</eissn><abstract>Vitamin C may have positive effects on wound healing and improve quality of life and the recovery process. A systematic review was done to study the effects of vitamin C on the healing of wounds and thereby hasten rehabilitation. Randomized controlled trials (RCTs) and controlled clinical trials on the effects of vitamin C were searched for using PubMed, Google Scholar, Science Direct, and Cochrane Library. Data was collected, analyzed, and assessed for risks of bias using Cochrane review protocols and tools. A total of 24 trials were procured, but after excluding 21 that did not meet the criteria, only three trials could be analyzed. Overall, addition of vitamin C was noted to have 3.94 times likelihood of acquiring quicker recovery process as compared to placebo (OR 3.99, 95% CI 2.06 to 7.73), but there was no difference in pain (
p
> 0.05). Overall quality of evidence was good, with low risk of bias. Evidence shows that vitamin C promotes wound healing by hastening recovery and attaining high leucocyte ascorbic acid levels. It is recommended to use vitamin C for wound healing while waiting for more RCTs to strengthen this evidence.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s12262-023-03750-y</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9317-475X</orcidid></addata></record> |
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| subjects | Cardiac Surgery Medicine Medicine & Public Health Neurosurgery Pediatric Surgery Plastic Surgery Review Article Surgery Systematic review Thoracic Surgery Vitamin C Wound healing |
| title | The Effects of Vitamin C on Wound Healing—Systematic Review |
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