Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [18F]FDG tumor kinetic metrics
Purpose To investigate the feasibility of reducing the acquisition time for continuous dynamic positron emission tomography (PET) while retaining acceptable performance in quantifying kinetic metrics of 2-[ 18 F]-fluoro-2-deoxy-D-glucose ([ 18 F]FDG) in tumors. Methods In total, 78 oncological patie...
Gespeichert in:
| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2024-04, Vol.51 (5), p.1371-1382 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1382 |
|---|---|
| container_issue | 5 |
| container_start_page | 1371 |
| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 51 |
| creator | Liu, Guobing Shi, Yimeng Hou, Xiaoguang Yu, Haojun Hu, Yan Zhang, Yiqiu Shi, Hongcheng |
| description | Purpose
To investigate the feasibility of reducing the acquisition time for continuous dynamic positron emission tomography (PET) while retaining acceptable performance in quantifying kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-D-glucose ([
18
F]FDG) in tumors.
Methods
In total, 78 oncological patients underwent total-body dynamic PET imaging for ≥ 60 min, with 8, 20, and 50 patients receiving full activity (3.7 MBq/kg), half activity (1.85 MBq/kg), and ultra-low activity (0.37 MBq/kg) of [
18
F]FDG, respectively. The dynamic data were divided into 21-, 30-, 45- and ≥ 60-min groups. The kinetic analysis involved model fitting to derive constant rates (
V
B
,
K
1
to
k
3
, and
Ki
) for both tumors and normal tissues, using both reversible and irreversible two-tissue-compartment models. One-way ANOVA with repeated measures or the Freidman test compared the kinetic metrics among groups, while the Deming regression assessed the correlation of kinetic metrics among groups.
Results
All kinetic metrics in the 30-min and 45-min groups were statistically comparable to those in the ≥ 60-min group. The relative differences between the 30-min and ≥ 60-min groups ranged from 12.3% ± 15.1% for
K
1
to 29.8% ± 30.0% for
V
B
, and those between the 45-min and ≥ 60-min groups ranged from 7.5% ± 8.7% for
Ki
to 24.0% ± 24.3% for
V
B
. However, this comparability was not observed between the 21-min and ≥ 60-min groups. The significance trend of these comparisons remained consistent across different models (reversible or irreversible), administrated activity levels, and partial volume corrections for lesions. Significant correlations in tumor kinetic metrics were identified between the 30-/45-min and ≥ 60-min groups, with Deming regression slopes > 0.813. In addition, the comparability of kinetic metrics between the 30-min and ≥ 60-min groups were established for normal tissues.
Conclusion
The acquisition time for dynamic PET imaging can be reduced to 30 min without compromising the ability to reveal tumor kinetic metrics of [
18
F]FDG, using the total-body PET/CT system. |
| doi_str_mv | 10.1007/s00259-023-06526-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2972958058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2972958058</sourcerecordid><originalsourceid>FETCH-LOGICAL-c293t-12697bf4540326343ed0233cbafd1e397e09a6cd9cc7b247ea5d5206fc8cde873</originalsourceid><addsrcrecordid>eNp9UctuEzEUtRCIlsIPsECWWA_1Y2ZsL1HaFKRK7SJdVcjy2HdSl4yd2B5V-Qs-GdO0ZdfVta7P4-ochD5T8o0SIk4zIaxTDWG8IX3H-qZ9g45pT1UjiFRvX96CHKEPOd8TQiWT6j064pIIqTpyjP6c7YOZvMUlFrNphuj2-Pp8dbpYYT-ZtQ9r_ODLHU7gZgsOG7ubffbFx4CLnwDnu_iQ69rCtphhA3gLaYxpMsEC9gHvZhOKH701j5w44lsql7-WZxe4zFNM-LcPUOoBE5Tkbf6I3o1mk-HT0zxBN8vz1eJHc3l18XPx_bKxTPHSUNYrMYxt1xLOet5ycDUHbgczOgpcCSDK9NYpa8XAWgGmcx0j_WildSAFP0FfD7rbFHcz5KLv45xCtdRMCaY6STpZUeyAsinmnGDU21RzSXtNif5Xgj6UoKu5fixBt5X05Ul6HiZwL5Tn1CuAHwC5foU1pP_er8j-BfjwlA8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2972958058</pqid></control><display><type>article</type><title>Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [18F]FDG tumor kinetic metrics</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Liu, Guobing ; Shi, Yimeng ; Hou, Xiaoguang ; Yu, Haojun ; Hu, Yan ; Zhang, Yiqiu ; Shi, Hongcheng</creator><creatorcontrib>Liu, Guobing ; Shi, Yimeng ; Hou, Xiaoguang ; Yu, Haojun ; Hu, Yan ; Zhang, Yiqiu ; Shi, Hongcheng</creatorcontrib><description>Purpose
To investigate the feasibility of reducing the acquisition time for continuous dynamic positron emission tomography (PET) while retaining acceptable performance in quantifying kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-D-glucose ([
18
F]FDG) in tumors.
Methods
In total, 78 oncological patients underwent total-body dynamic PET imaging for ≥ 60 min, with 8, 20, and 50 patients receiving full activity (3.7 MBq/kg), half activity (1.85 MBq/kg), and ultra-low activity (0.37 MBq/kg) of [
18
F]FDG, respectively. The dynamic data were divided into 21-, 30-, 45- and ≥ 60-min groups. The kinetic analysis involved model fitting to derive constant rates (
V
B
,
K
1
to
k
3
, and
Ki
) for both tumors and normal tissues, using both reversible and irreversible two-tissue-compartment models. One-way ANOVA with repeated measures or the Freidman test compared the kinetic metrics among groups, while the Deming regression assessed the correlation of kinetic metrics among groups.
Results
All kinetic metrics in the 30-min and 45-min groups were statistically comparable to those in the ≥ 60-min group. The relative differences between the 30-min and ≥ 60-min groups ranged from 12.3% ± 15.1% for
K
1
to 29.8% ± 30.0% for
V
B
, and those between the 45-min and ≥ 60-min groups ranged from 7.5% ± 8.7% for
Ki
to 24.0% ± 24.3% for
V
B
. However, this comparability was not observed between the 21-min and ≥ 60-min groups. The significance trend of these comparisons remained consistent across different models (reversible or irreversible), administrated activity levels, and partial volume corrections for lesions. Significant correlations in tumor kinetic metrics were identified between the 30-/45-min and ≥ 60-min groups, with Deming regression slopes > 0.813. In addition, the comparability of kinetic metrics between the 30-min and ≥ 60-min groups were established for normal tissues.
Conclusion
The acquisition time for dynamic PET imaging can be reduced to 30 min without compromising the ability to reveal tumor kinetic metrics of [
18
F]FDG, using the total-body PET/CT system.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-023-06526-4</identifier><identifier>PMID: 38078950</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cardiology ; Computed tomography ; Fluorine isotopes ; Fluorodeoxyglucose F18 ; Glucose ; Humans ; Imaging ; Kinetics ; Medical imaging ; Medicine ; Medicine & Public Health ; Neoplasms - diagnostic imaging ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography - methods ; Radiology ; Tumors</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2024-04, Vol.51 (5), p.1371-1382</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c293t-12697bf4540326343ed0233cbafd1e397e09a6cd9cc7b247ea5d5206fc8cde873</cites><orcidid>0000-0001-7457-876X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-023-06526-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-023-06526-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38078950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Guobing</creatorcontrib><creatorcontrib>Shi, Yimeng</creatorcontrib><creatorcontrib>Hou, Xiaoguang</creatorcontrib><creatorcontrib>Yu, Haojun</creatorcontrib><creatorcontrib>Hu, Yan</creatorcontrib><creatorcontrib>Zhang, Yiqiu</creatorcontrib><creatorcontrib>Shi, Hongcheng</creatorcontrib><title>Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [18F]FDG tumor kinetic metrics</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
To investigate the feasibility of reducing the acquisition time for continuous dynamic positron emission tomography (PET) while retaining acceptable performance in quantifying kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-D-glucose ([
18
F]FDG) in tumors.
Methods
In total, 78 oncological patients underwent total-body dynamic PET imaging for ≥ 60 min, with 8, 20, and 50 patients receiving full activity (3.7 MBq/kg), half activity (1.85 MBq/kg), and ultra-low activity (0.37 MBq/kg) of [
18
F]FDG, respectively. The dynamic data were divided into 21-, 30-, 45- and ≥ 60-min groups. The kinetic analysis involved model fitting to derive constant rates (
V
B
,
K
1
to
k
3
, and
Ki
) for both tumors and normal tissues, using both reversible and irreversible two-tissue-compartment models. One-way ANOVA with repeated measures or the Freidman test compared the kinetic metrics among groups, while the Deming regression assessed the correlation of kinetic metrics among groups.
Results
All kinetic metrics in the 30-min and 45-min groups were statistically comparable to those in the ≥ 60-min group. The relative differences between the 30-min and ≥ 60-min groups ranged from 12.3% ± 15.1% for
K
1
to 29.8% ± 30.0% for
V
B
, and those between the 45-min and ≥ 60-min groups ranged from 7.5% ± 8.7% for
Ki
to 24.0% ± 24.3% for
V
B
. However, this comparability was not observed between the 21-min and ≥ 60-min groups. The significance trend of these comparisons remained consistent across different models (reversible or irreversible), administrated activity levels, and partial volume corrections for lesions. Significant correlations in tumor kinetic metrics were identified between the 30-/45-min and ≥ 60-min groups, with Deming regression slopes > 0.813. In addition, the comparability of kinetic metrics between the 30-min and ≥ 60-min groups were established for normal tissues.
Conclusion
The acquisition time for dynamic PET imaging can be reduced to 30 min without compromising the ability to reveal tumor kinetic metrics of [
18
F]FDG, using the total-body PET/CT system.</description><subject>Cardiology</subject><subject>Computed tomography</subject><subject>Fluorine isotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Glucose</subject><subject>Humans</subject><subject>Imaging</subject><subject>Kinetics</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiology</subject><subject>Tumors</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctuEzEUtRCIlsIPsECWWA_1Y2ZsL1HaFKRK7SJdVcjy2HdSl4yd2B5V-Qs-GdO0ZdfVta7P4-ochD5T8o0SIk4zIaxTDWG8IX3H-qZ9g45pT1UjiFRvX96CHKEPOd8TQiWT6j064pIIqTpyjP6c7YOZvMUlFrNphuj2-Pp8dbpYYT-ZtQ9r_ODLHU7gZgsOG7ubffbFx4CLnwDnu_iQ69rCtphhA3gLaYxpMsEC9gHvZhOKH701j5w44lsql7-WZxe4zFNM-LcPUOoBE5Tkbf6I3o1mk-HT0zxBN8vz1eJHc3l18XPx_bKxTPHSUNYrMYxt1xLOet5ycDUHbgczOgpcCSDK9NYpa8XAWgGmcx0j_WildSAFP0FfD7rbFHcz5KLv45xCtdRMCaY6STpZUeyAsinmnGDU21RzSXtNif5Xgj6UoKu5fixBt5X05Ul6HiZwL5Tn1CuAHwC5foU1pP_er8j-BfjwlA8</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Liu, Guobing</creator><creator>Shi, Yimeng</creator><creator>Hou, Xiaoguang</creator><creator>Yu, Haojun</creator><creator>Hu, Yan</creator><creator>Zhang, Yiqiu</creator><creator>Shi, Hongcheng</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0001-7457-876X</orcidid></search><sort><creationdate>20240401</creationdate><title>Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [18F]FDG tumor kinetic metrics</title><author>Liu, Guobing ; Shi, Yimeng ; Hou, Xiaoguang ; Yu, Haojun ; Hu, Yan ; Zhang, Yiqiu ; Shi, Hongcheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-12697bf4540326343ed0233cbafd1e397e09a6cd9cc7b247ea5d5206fc8cde873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiology</topic><topic>Computed tomography</topic><topic>Fluorine isotopes</topic><topic>Fluorodeoxyglucose F18</topic><topic>Glucose</topic><topic>Humans</topic><topic>Imaging</topic><topic>Kinetics</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Guobing</creatorcontrib><creatorcontrib>Shi, Yimeng</creatorcontrib><creatorcontrib>Hou, Xiaoguang</creatorcontrib><creatorcontrib>Yu, Haojun</creatorcontrib><creatorcontrib>Hu, Yan</creatorcontrib><creatorcontrib>Zhang, Yiqiu</creatorcontrib><creatorcontrib>Shi, Hongcheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Guobing</au><au>Shi, Yimeng</au><au>Hou, Xiaoguang</au><au>Yu, Haojun</au><au>Hu, Yan</au><au>Zhang, Yiqiu</au><au>Shi, Hongcheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [18F]FDG tumor kinetic metrics</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>51</volume><issue>5</issue><spage>1371</spage><epage>1382</epage><pages>1371-1382</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
To investigate the feasibility of reducing the acquisition time for continuous dynamic positron emission tomography (PET) while retaining acceptable performance in quantifying kinetic metrics of 2-[
18
F]-fluoro-2-deoxy-D-glucose ([
18
F]FDG) in tumors.
Methods
In total, 78 oncological patients underwent total-body dynamic PET imaging for ≥ 60 min, with 8, 20, and 50 patients receiving full activity (3.7 MBq/kg), half activity (1.85 MBq/kg), and ultra-low activity (0.37 MBq/kg) of [
18
F]FDG, respectively. The dynamic data were divided into 21-, 30-, 45- and ≥ 60-min groups. The kinetic analysis involved model fitting to derive constant rates (
V
B
,
K
1
to
k
3
, and
Ki
) for both tumors and normal tissues, using both reversible and irreversible two-tissue-compartment models. One-way ANOVA with repeated measures or the Freidman test compared the kinetic metrics among groups, while the Deming regression assessed the correlation of kinetic metrics among groups.
Results
All kinetic metrics in the 30-min and 45-min groups were statistically comparable to those in the ≥ 60-min group. The relative differences between the 30-min and ≥ 60-min groups ranged from 12.3% ± 15.1% for
K
1
to 29.8% ± 30.0% for
V
B
, and those between the 45-min and ≥ 60-min groups ranged from 7.5% ± 8.7% for
Ki
to 24.0% ± 24.3% for
V
B
. However, this comparability was not observed between the 21-min and ≥ 60-min groups. The significance trend of these comparisons remained consistent across different models (reversible or irreversible), administrated activity levels, and partial volume corrections for lesions. Significant correlations in tumor kinetic metrics were identified between the 30-/45-min and ≥ 60-min groups, with Deming regression slopes > 0.813. In addition, the comparability of kinetic metrics between the 30-min and ≥ 60-min groups were established for normal tissues.
Conclusion
The acquisition time for dynamic PET imaging can be reduced to 30 min without compromising the ability to reveal tumor kinetic metrics of [
18
F]FDG, using the total-body PET/CT system.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38078950</pmid><doi>10.1007/s00259-023-06526-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7457-876X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2024-04, Vol.51 (5), p.1371-1382 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_proquest_journals_2972958058 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Cardiology Computed tomography Fluorine isotopes Fluorodeoxyglucose F18 Glucose Humans Imaging Kinetics Medical imaging Medicine Medicine & Public Health Neoplasms - diagnostic imaging Nuclear Medicine Oncology Original Article Orthopedics Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Positron-Emission Tomography - methods Radiology Tumors |
| title | Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [18F]FDG tumor kinetic metrics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T09%3A28%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamic%20total-body%20PET/CT%20imaging%20with%20reduced%20acquisition%20time%20shows%20acceptable%20performance%20in%20quantification%20of%20%5B18F%5DFDG%20tumor%20kinetic%20metrics&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Liu,%20Guobing&rft.date=2024-04-01&rft.volume=51&rft.issue=5&rft.spage=1371&rft.epage=1382&rft.pages=1371-1382&rft.issn=1619-7070&rft.eissn=1619-7089&rft_id=info:doi/10.1007/s00259-023-06526-4&rft_dat=%3Cproquest_cross%3E2972958058%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2972958058&rft_id=info:pmid/38078950&rfr_iscdi=true |