Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study
The aim of the study was to evaluate the approaches of pediatric rheumatologists and pediatric hematologists to patients with similar musculoskeletal (MSK) complaints and to highlight the differences that general pediatricians should consider when referring patients to these specialties. This is a c...
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| Veröffentlicht in: | The Turkish journal of pediatrics 2024-01, Vol.66 (1), p.81-89 |
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| creator | Çağlayan, Şengül Koç, Begüm Şirin Baba, Özge Bağlan, Esra Kurucu, Burçak Yıldırım, Deniz Gezgin Ayhan, Aylin Canbolat Çakan, Mustafa Yener, Gülçin Otar Öztürk, Kübra Çakmak, Figen Sönmez, Hafize Emine Ayaz, Nuray Aktay Kısaarslan, Ayşenur Paç Bakkaloğlu, Sevcan Kalyoncu, Mukaddes Kılıç, Suar Çakı Sözeri, Betül |
| description | The aim of the study was to evaluate the approaches of pediatric rheumatologists and pediatric hematologists to patients with similar musculoskeletal (MSK) complaints and to highlight the differences that general pediatricians should consider when referring patients to these specialties.
This is a cross-sectional study involving the patients who applied to pediatric rheumatology centers with MSK complaints and were diagnosed with malignancy, as well as patients who were followed up in pediatric hematology centers with a malignancy diagnosis, and had MSK complaints at the time of admission.
A total of 142 patients were enrolled in the study. Of these patients, 83 (58.4%) applied to pediatric rheumatology centers, and 59 (41.6%) applied to pediatric hematology centers. Acute lymphoblastic leukemia (ALL) was the most common diagnosis among the patients who applied to both centers, with 80 cases (56.3%). The median age of diagnosis was 87 (interquartile range, IQR: 48-140) months. The most common preliminary diagnosis in pediatric rheumatology centers was juvenile idiopathic arthritis (JIA), with 37 cases (44.5%). MSK involvement was mainly seen as arthralgia, and bone pain. While arthralgia (92.7%) was the most common complaint in rheumatology centers, bone pain (88.1%) was more common in hematology centers. The most frequently involved joints were the knee (62.9%), ankle (25.9%), hip (25%), and wrist (14%). The most common laboratory abnormalities were high lactate dehydrogenase (LDH), high C-reactive protein (CRP), anemia, and high erythrocyte sedimentation rate (ESR). Thrombocytopenia, neutropenia, and high LDH were statistically significantly more frequent in patients admitted to hematology centers than in patients admitted to rheumatology centers (p < 0.001, p=0.014, p=0.028, respectively). Patients who applied to rheumatology clinics were found to have statistically significantly higher CRP levels (p=0.032).
Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints. |
| doi_str_mv | 10.24953/turkjped.2023.446 |
| format | Article |
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This is a cross-sectional study involving the patients who applied to pediatric rheumatology centers with MSK complaints and were diagnosed with malignancy, as well as patients who were followed up in pediatric hematology centers with a malignancy diagnosis, and had MSK complaints at the time of admission.
A total of 142 patients were enrolled in the study. Of these patients, 83 (58.4%) applied to pediatric rheumatology centers, and 59 (41.6%) applied to pediatric hematology centers. Acute lymphoblastic leukemia (ALL) was the most common diagnosis among the patients who applied to both centers, with 80 cases (56.3%). The median age of diagnosis was 87 (interquartile range, IQR: 48-140) months. The most common preliminary diagnosis in pediatric rheumatology centers was juvenile idiopathic arthritis (JIA), with 37 cases (44.5%). MSK involvement was mainly seen as arthralgia, and bone pain. While arthralgia (92.7%) was the most common complaint in rheumatology centers, bone pain (88.1%) was more common in hematology centers. The most frequently involved joints were the knee (62.9%), ankle (25.9%), hip (25%), and wrist (14%). The most common laboratory abnormalities were high lactate dehydrogenase (LDH), high C-reactive protein (CRP), anemia, and high erythrocyte sedimentation rate (ESR). Thrombocytopenia, neutropenia, and high LDH were statistically significantly more frequent in patients admitted to hematology centers than in patients admitted to rheumatology centers (p < 0.001, p=0.014, p=0.028, respectively). Patients who applied to rheumatology clinics were found to have statistically significantly higher CRP levels (p=0.032).
Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.</description><identifier>ISSN: 0041-4301</identifier><identifier>EISSN: 2791-6421</identifier><identifier>DOI: 10.24953/turkjped.2023.446</identifier><identifier>PMID: 38523382</identifier><language>eng</language><publisher>Turkey: Akdema Informatics and Publishing</publisher><subject>Analysis ; Anemia ; Arthritis ; Blood ; C-reactive protein ; Cancer ; Complaints ; Cross-sectional studies ; Dehydrogenases ; Ewings sarcoma ; Fever ; Hematology ; Laboratories ; Leukemia ; Lymphoma ; Medical examination ; Medical prognosis ; Medical research ; Medicine, Experimental ; Neuroblastoma ; Neutropenia ; Pain ; Pediatrics ; Rheumatic diseases ; Rheumatology ; Thrombocytopenia</subject><ispartof>The Turkish journal of pediatrics, 2024-01, Vol.66 (1), p.81-89</ispartof><rights>COPYRIGHT 2024 Akdema Informatics and Publishing</rights><rights>Copyright Hacettepe University Faculty of Medicine Jan/Feb 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-e9502f77975ac89adb4f5cce3ffad8f7c3af740712a53725e2b535e8d8359eb93</cites><orcidid>0000-0002-1800-9922 ; 0000-0002-2442-1550 ; 0000-0002-9186-3068 ; 0000-0001-7489-2054 ; 0000-0002-4823-2076 ; 0000-0002-6127-3147 ; 0000-0001-5637-8553 ; 0000-0003-3594-7387 ; 0000-0003-2575-6309 ; 0000-0002-1667-2480 ; 0000-0003-3014-5692 ; 0000-0003-3474-5070 ; 0000-0001-5378-939X ; 0000-0002-1034-6406 ; 0000-0003-0466-0228 ; 0000-0001-6173-2350 ; 0000-0002-5079-5644 ; 0000-0001-6530-9672</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38523382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çağlayan, Şengül</creatorcontrib><creatorcontrib>Koç, Begüm Şirin</creatorcontrib><creatorcontrib>Baba, Özge</creatorcontrib><creatorcontrib>Bağlan, Esra</creatorcontrib><creatorcontrib>Kurucu, Burçak</creatorcontrib><creatorcontrib>Yıldırım, Deniz Gezgin</creatorcontrib><creatorcontrib>Ayhan, Aylin Canbolat</creatorcontrib><creatorcontrib>Çakan, Mustafa</creatorcontrib><creatorcontrib>Yener, Gülçin Otar</creatorcontrib><creatorcontrib>Öztürk, Kübra</creatorcontrib><creatorcontrib>Çakmak, Figen</creatorcontrib><creatorcontrib>Sönmez, Hafize Emine</creatorcontrib><creatorcontrib>Ayaz, Nuray Aktay</creatorcontrib><creatorcontrib>Kısaarslan, Ayşenur Paç</creatorcontrib><creatorcontrib>Bakkaloğlu, Sevcan</creatorcontrib><creatorcontrib>Kalyoncu, Mukaddes</creatorcontrib><creatorcontrib>Kılıç, Suar Çakı</creatorcontrib><creatorcontrib>Sözeri, Betül</creatorcontrib><title>Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study</title><title>The Turkish journal of pediatrics</title><addtitle>Turk J Pediatr</addtitle><description>The aim of the study was to evaluate the approaches of pediatric rheumatologists and pediatric hematologists to patients with similar musculoskeletal (MSK) complaints and to highlight the differences that general pediatricians should consider when referring patients to these specialties.
This is a cross-sectional study involving the patients who applied to pediatric rheumatology centers with MSK complaints and were diagnosed with malignancy, as well as patients who were followed up in pediatric hematology centers with a malignancy diagnosis, and had MSK complaints at the time of admission.
A total of 142 patients were enrolled in the study. Of these patients, 83 (58.4%) applied to pediatric rheumatology centers, and 59 (41.6%) applied to pediatric hematology centers. Acute lymphoblastic leukemia (ALL) was the most common diagnosis among the patients who applied to both centers, with 80 cases (56.3%). The median age of diagnosis was 87 (interquartile range, IQR: 48-140) months. The most common preliminary diagnosis in pediatric rheumatology centers was juvenile idiopathic arthritis (JIA), with 37 cases (44.5%). MSK involvement was mainly seen as arthralgia, and bone pain. While arthralgia (92.7%) was the most common complaint in rheumatology centers, bone pain (88.1%) was more common in hematology centers. The most frequently involved joints were the knee (62.9%), ankle (25.9%), hip (25%), and wrist (14%). The most common laboratory abnormalities were high lactate dehydrogenase (LDH), high C-reactive protein (CRP), anemia, and high erythrocyte sedimentation rate (ESR). Thrombocytopenia, neutropenia, and high LDH were statistically significantly more frequent in patients admitted to hematology centers than in patients admitted to rheumatology centers (p < 0.001, p=0.014, p=0.028, respectively). Patients who applied to rheumatology clinics were found to have statistically significantly higher CRP levels (p=0.032).
Malignancies may present with only MSK system complaints in childhood. 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of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study</title><author>Çağlayan, Şengül ; Koç, Begüm Şirin ; Baba, Özge ; Bağlan, Esra ; Kurucu, Burçak ; Yıldırım, Deniz Gezgin ; Ayhan, Aylin Canbolat ; Çakan, Mustafa ; Yener, Gülçin Otar ; Öztürk, Kübra ; Çakmak, Figen ; Sönmez, Hafize Emine ; Ayaz, Nuray Aktay ; Kısaarslan, Ayşenur Paç ; Bakkaloğlu, Sevcan ; Kalyoncu, Mukaddes ; Kılıç, Suar Çakı ; Sözeri, Betül</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-e9502f77975ac89adb4f5cce3ffad8f7c3af740712a53725e2b535e8d8359eb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Anemia</topic><topic>Arthritis</topic><topic>Blood</topic><topic>C-reactive protein</topic><topic>Cancer</topic><topic>Complaints</topic><topic>Cross-sectional studies</topic><topic>Dehydrogenases</topic><topic>Ewings sarcoma</topic><topic>Fever</topic><topic>Hematology</topic><topic>Laboratories</topic><topic>Leukemia</topic><topic>Lymphoma</topic><topic>Medical examination</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Neuroblastoma</topic><topic>Neutropenia</topic><topic>Pain</topic><topic>Pediatrics</topic><topic>Rheumatic diseases</topic><topic>Rheumatology</topic><topic>Thrombocytopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çağlayan, Şengül</creatorcontrib><creatorcontrib>Koç, Begüm Şirin</creatorcontrib><creatorcontrib>Baba, Özge</creatorcontrib><creatorcontrib>Bağlan, Esra</creatorcontrib><creatorcontrib>Kurucu, Burçak</creatorcontrib><creatorcontrib>Yıldırım, Deniz Gezgin</creatorcontrib><creatorcontrib>Ayhan, Aylin Canbolat</creatorcontrib><creatorcontrib>Çakan, Mustafa</creatorcontrib><creatorcontrib>Yener, 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Betül</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study</atitle><jtitle>The Turkish journal of pediatrics</jtitle><addtitle>Turk J Pediatr</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>66</volume><issue>1</issue><spage>81</spage><epage>89</epage><pages>81-89</pages><issn>0041-4301</issn><eissn>2791-6421</eissn><abstract>The aim of the study was to evaluate the approaches of pediatric rheumatologists and pediatric hematologists to patients with similar musculoskeletal (MSK) complaints and to highlight the differences that general pediatricians should consider when referring patients to these specialties.
This is a cross-sectional study involving the patients who applied to pediatric rheumatology centers with MSK complaints and were diagnosed with malignancy, as well as patients who were followed up in pediatric hematology centers with a malignancy diagnosis, and had MSK complaints at the time of admission.
A total of 142 patients were enrolled in the study. Of these patients, 83 (58.4%) applied to pediatric rheumatology centers, and 59 (41.6%) applied to pediatric hematology centers. Acute lymphoblastic leukemia (ALL) was the most common diagnosis among the patients who applied to both centers, with 80 cases (56.3%). The median age of diagnosis was 87 (interquartile range, IQR: 48-140) months. The most common preliminary diagnosis in pediatric rheumatology centers was juvenile idiopathic arthritis (JIA), with 37 cases (44.5%). MSK involvement was mainly seen as arthralgia, and bone pain. While arthralgia (92.7%) was the most common complaint in rheumatology centers, bone pain (88.1%) was more common in hematology centers. The most frequently involved joints were the knee (62.9%), ankle (25.9%), hip (25%), and wrist (14%). The most common laboratory abnormalities were high lactate dehydrogenase (LDH), high C-reactive protein (CRP), anemia, and high erythrocyte sedimentation rate (ESR). Thrombocytopenia, neutropenia, and high LDH were statistically significantly more frequent in patients admitted to hematology centers than in patients admitted to rheumatology centers (p < 0.001, p=0.014, p=0.028, respectively). Patients who applied to rheumatology clinics were found to have statistically significantly higher CRP levels (p=0.032).
Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.</abstract><cop>Turkey</cop><pub>Akdema Informatics and Publishing</pub><pmid>38523382</pmid><doi>10.24953/turkjped.2023.446</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1800-9922</orcidid><orcidid>https://orcid.org/0000-0002-2442-1550</orcidid><orcidid>https://orcid.org/0000-0002-9186-3068</orcidid><orcidid>https://orcid.org/0000-0001-7489-2054</orcidid><orcidid>https://orcid.org/0000-0002-4823-2076</orcidid><orcidid>https://orcid.org/0000-0002-6127-3147</orcidid><orcidid>https://orcid.org/0000-0001-5637-8553</orcidid><orcidid>https://orcid.org/0000-0003-3594-7387</orcidid><orcidid>https://orcid.org/0000-0003-2575-6309</orcidid><orcidid>https://orcid.org/0000-0002-1667-2480</orcidid><orcidid>https://orcid.org/0000-0003-3014-5692</orcidid><orcidid>https://orcid.org/0000-0003-3474-5070</orcidid><orcidid>https://orcid.org/0000-0001-5378-939X</orcidid><orcidid>https://orcid.org/0000-0002-1034-6406</orcidid><orcidid>https://orcid.org/0000-0003-0466-0228</orcidid><orcidid>https://orcid.org/0000-0001-6173-2350</orcidid><orcidid>https://orcid.org/0000-0002-5079-5644</orcidid><orcidid>https://orcid.org/0000-0001-6530-9672</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-4301 |
| ispartof | The Turkish journal of pediatrics, 2024-01, Vol.66 (1), p.81-89 |
| issn | 0041-4301 2791-6421 |
| language | eng |
| recordid | cdi_proquest_journals_2972786087 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis Anemia Arthritis Blood C-reactive protein Cancer Complaints Cross-sectional studies Dehydrogenases Ewings sarcoma Fever Hematology Laboratories Leukemia Lymphoma Medical examination Medical prognosis Medical research Medicine, Experimental Neuroblastoma Neutropenia Pain Pediatrics Rheumatic diseases Rheumatology Thrombocytopenia |
| title | Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study |
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