Selenium Deficiency is associated with inflammation and Cardio- metabolic dysregulation in women with Hypertensive disorders of Pregnancy
Abstract Introduction/Objective Selenium (Se) deficiency has been speculated to enhance Oxidative inflammation in Pregnancy, leading to endothelial dysfunction, which has been implicated in the aetiopathogenesis of Hypertensive disorders of Pregnancy. This study aimed at evaluating the Selenium Stat...
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description | Abstract
Introduction/Objective
Selenium (Se) deficiency has been speculated to enhance Oxidative inflammation in Pregnancy, leading to endothelial dysfunction, which has been implicated in the aetiopathogenesis of Hypertensive disorders of Pregnancy. This study aimed at evaluating the Selenium Status of pregnant women and its role in inflammation and cardio-metabolism in pregnant women with Hypertensive disorders of Pregnancy.
Methods/Case Report
The study involved 200 healthy women with Single Pregnancy who presented to Obstetrics and Gynaecology clinic of IMSUTH Teaching Hospital, Nigeria. These subjects were recruited between 10 to 15 weeks of gestation. 52 of the them who subsequently developed Hypertensive disorders ;Preeclampsia (PE)-15 and Pregnancy Induced Hypertension (PIH)- 37) were compared with their148 counterparts who remained Normotensive. The groups were matched for age, BMI, gestational age and parity. The blood Selenium levels were determined using Atomic Absorption spectrophotometer, while ELIZA was used for Markers of Inflammation and Cardio-metabolic risk (Hs Crp, Lipid profile, Insuline, MDA,TAC, GSH). P 0.005).. There was also a significant increase in the Insulin levels of the PE group compared with the Control group. There was a negative correlation relationship between Selenium and Hs- CRP (r = -0.533, r=-601), serum lipids and Insulin and BMI in the study groups.
Conclusion
From our study, Selenium deficiency may be associated with Dyslipidemia, impaired Insulin Metabolism and may serve as a predictive Risk marker of Heart disease in women with Hypertensive disorders of Pregnancy. |
doi_str_mv | 10.1093/ajcp/aqad150.125 |
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Introduction/Objective
Selenium (Se) deficiency has been speculated to enhance Oxidative inflammation in Pregnancy, leading to endothelial dysfunction, which has been implicated in the aetiopathogenesis of Hypertensive disorders of Pregnancy. This study aimed at evaluating the Selenium Status of pregnant women and its role in inflammation and cardio-metabolism in pregnant women with Hypertensive disorders of Pregnancy.
Methods/Case Report
The study involved 200 healthy women with Single Pregnancy who presented to Obstetrics and Gynaecology clinic of IMSUTH Teaching Hospital, Nigeria. These subjects were recruited between 10 to 15 weeks of gestation. 52 of the them who subsequently developed Hypertensive disorders ;Preeclampsia (PE)-15 and Pregnancy Induced Hypertension (PIH)- 37) were compared with their148 counterparts who remained Normotensive. The groups were matched for age, BMI, gestational age and parity. The blood Selenium levels were determined using Atomic Absorption spectrophotometer, while ELIZA was used for Markers of Inflammation and Cardio-metabolic risk (Hs Crp, Lipid profile, Insuline, MDA,TAC, GSH). P <0.05 was considered statistically significant for all variables.
Results (if a Case Study enter NA)
There was significant reduction in the mean levels of Selenium in Pregnant women with PE and PIH (52.41 μg/L, 56.02 μg/L) when compared with Normotensive (68.84 μg/L). Hs-CRP, LDL and MDA showed significant increase in the study groups (PE and PIH) against the Normotensive group (p=0.001,
0.004 and 0.001) respectively. A significant reduction was observed in the TAC and GSH in PE and PIH (p> 0.005).. There was also a significant increase in the Insulin levels of the PE group compared with the Control group. There was a negative correlation relationship between Selenium and Hs- CRP (r = -0.533, r=-601), serum lipids and Insulin and BMI in the study groups.
Conclusion
From our study, Selenium deficiency may be associated with Dyslipidemia, impaired Insulin Metabolism and may serve as a predictive Risk marker of Heart disease in women with Hypertensive disorders of Pregnancy.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/aqad150.125</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Blood levels ; Dyslipidemia ; Gestational age ; Heart diseases ; Hypertension ; Inflammation ; Insulin ; Lipids ; Low density lipoprotein ; Metabolism ; Obstetrics ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Pregnancy complications ; Selenium ; Serum lipids ; Statistical analysis</subject><ispartof>American journal of clinical pathology, 2023-11, Vol.160 (Supplement_1), p.S55-S56</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27907,27908</link.rule.ids></links><search><creatorcontrib>Nwadike, C N</creatorcontrib><creatorcontrib>Nwanjo, H U</creatorcontrib><creatorcontrib>Ikaraoha, C I</creatorcontrib><creatorcontrib>Ogbuokiri, A C</creatorcontrib><title>Selenium Deficiency is associated with inflammation and Cardio- metabolic dysregulation in women with Hypertensive disorders of Pregnancy</title><title>American journal of clinical pathology</title><description>Abstract
Introduction/Objective
Selenium (Se) deficiency has been speculated to enhance Oxidative inflammation in Pregnancy, leading to endothelial dysfunction, which has been implicated in the aetiopathogenesis of Hypertensive disorders of Pregnancy. This study aimed at evaluating the Selenium Status of pregnant women and its role in inflammation and cardio-metabolism in pregnant women with Hypertensive disorders of Pregnancy.
Methods/Case Report
The study involved 200 healthy women with Single Pregnancy who presented to Obstetrics and Gynaecology clinic of IMSUTH Teaching Hospital, Nigeria. These subjects were recruited between 10 to 15 weeks of gestation. 52 of the them who subsequently developed Hypertensive disorders ;Preeclampsia (PE)-15 and Pregnancy Induced Hypertension (PIH)- 37) were compared with their148 counterparts who remained Normotensive. The groups were matched for age, BMI, gestational age and parity. The blood Selenium levels were determined using Atomic Absorption spectrophotometer, while ELIZA was used for Markers of Inflammation and Cardio-metabolic risk (Hs Crp, Lipid profile, Insuline, MDA,TAC, GSH). P <0.05 was considered statistically significant for all variables.
Results (if a Case Study enter NA)
There was significant reduction in the mean levels of Selenium in Pregnant women with PE and PIH (52.41 μg/L, 56.02 μg/L) when compared with Normotensive (68.84 μg/L). Hs-CRP, LDL and MDA showed significant increase in the study groups (PE and PIH) against the Normotensive group (p=0.001,
0.004 and 0.001) respectively. A significant reduction was observed in the TAC and GSH in PE and PIH (p> 0.005).. There was also a significant increase in the Insulin levels of the PE group compared with the Control group. There was a negative correlation relationship between Selenium and Hs- CRP (r = -0.533, r=-601), serum lipids and Insulin and BMI in the study groups.
Conclusion
From our study, Selenium deficiency may be associated with Dyslipidemia, impaired Insulin Metabolism and may serve as a predictive Risk marker of Heart disease in women with Hypertensive disorders of Pregnancy.</description><subject>Blood levels</subject><subject>Dyslipidemia</subject><subject>Gestational age</subject><subject>Heart diseases</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Metabolism</subject><subject>Obstetrics</subject><subject>Pre-eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Selenium</subject><subject>Serum lipids</subject><subject>Statistical analysis</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkE1LxDAQhoMouK7ePQY8St0kTdvtUdaPFRYU1HOZphPN0ibdpHXpT_Bf26V79zQwPM-8zEvINWd3nOXxAraqXcAOKp6MG5GckBnPZRxlmRCnZMYYE1HOs_icXISwZYyLJZMz8vuONVrTN_QBtVEGrRqoCRRCcMpAhxXdm-6bGqtraBrojLMUbEVX4CvjItpgB6WrjaLVEDx-9fXEGEv3rkE76euhRd-hDeYHaWWC8xX6QJ2mb6NjYUy9JGca6oBXxzknn0-PH6t1tHl9flndbyLFZZZEOQATGlHKFECIVHEBiArLdJlKLVOGS0zjTGcJSiFyiXEOSQwyV7gsKyzjObmZ7rbe7XoMXbF1vbdjZCHyJBEiYSkfKTZRyrsw_qWL1psG_FBwVhwKLw6FF8fCi7HwUbmdFNe3_9N_f0iHhw</recordid><startdate>20231129</startdate><enddate>20231129</enddate><creator>Nwadike, C N</creator><creator>Nwanjo, H U</creator><creator>Ikaraoha, C I</creator><creator>Ogbuokiri, A C</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20231129</creationdate><title>Selenium Deficiency is associated with inflammation and Cardio- metabolic dysregulation in women with Hypertensive disorders of Pregnancy</title><author>Nwadike, C N ; Nwanjo, H U ; Ikaraoha, C I ; Ogbuokiri, A C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1475-9aa02fee446aa226c12aeeceb6864f460e8e637f75e42294e39a53a49ce8bdeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Blood levels</topic><topic>Dyslipidemia</topic><topic>Gestational age</topic><topic>Heart diseases</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Metabolism</topic><topic>Obstetrics</topic><topic>Pre-eclampsia</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Selenium</topic><topic>Serum lipids</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nwadike, C N</creatorcontrib><creatorcontrib>Nwanjo, H U</creatorcontrib><creatorcontrib>Ikaraoha, C I</creatorcontrib><creatorcontrib>Ogbuokiri, A C</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nwadike, C N</au><au>Nwanjo, H U</au><au>Ikaraoha, C I</au><au>Ogbuokiri, A C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selenium Deficiency is associated with inflammation and Cardio- metabolic dysregulation in women with Hypertensive disorders of Pregnancy</atitle><jtitle>American journal of clinical pathology</jtitle><date>2023-11-29</date><risdate>2023</risdate><volume>160</volume><issue>Supplement_1</issue><spage>S55</spage><epage>S56</epage><pages>S55-S56</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>Abstract
Introduction/Objective
Selenium (Se) deficiency has been speculated to enhance Oxidative inflammation in Pregnancy, leading to endothelial dysfunction, which has been implicated in the aetiopathogenesis of Hypertensive disorders of Pregnancy. This study aimed at evaluating the Selenium Status of pregnant women and its role in inflammation and cardio-metabolism in pregnant women with Hypertensive disorders of Pregnancy.
Methods/Case Report
The study involved 200 healthy women with Single Pregnancy who presented to Obstetrics and Gynaecology clinic of IMSUTH Teaching Hospital, Nigeria. These subjects were recruited between 10 to 15 weeks of gestation. 52 of the them who subsequently developed Hypertensive disorders ;Preeclampsia (PE)-15 and Pregnancy Induced Hypertension (PIH)- 37) were compared with their148 counterparts who remained Normotensive. The groups were matched for age, BMI, gestational age and parity. The blood Selenium levels were determined using Atomic Absorption spectrophotometer, while ELIZA was used for Markers of Inflammation and Cardio-metabolic risk (Hs Crp, Lipid profile, Insuline, MDA,TAC, GSH). P <0.05 was considered statistically significant for all variables.
Results (if a Case Study enter NA)
There was significant reduction in the mean levels of Selenium in Pregnant women with PE and PIH (52.41 μg/L, 56.02 μg/L) when compared with Normotensive (68.84 μg/L). Hs-CRP, LDL and MDA showed significant increase in the study groups (PE and PIH) against the Normotensive group (p=0.001,
0.004 and 0.001) respectively. A significant reduction was observed in the TAC and GSH in PE and PIH (p> 0.005).. There was also a significant increase in the Insulin levels of the PE group compared with the Control group. There was a negative correlation relationship between Selenium and Hs- CRP (r = -0.533, r=-601), serum lipids and Insulin and BMI in the study groups.
Conclusion
From our study, Selenium deficiency may be associated with Dyslipidemia, impaired Insulin Metabolism and may serve as a predictive Risk marker of Heart disease in women with Hypertensive disorders of Pregnancy.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/ajcp/aqad150.125</doi><oa>free_for_read</oa></addata></record> |
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source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Blood levels Dyslipidemia Gestational age Heart diseases Hypertension Inflammation Insulin Lipids Low density lipoprotein Metabolism Obstetrics Pre-eclampsia Preeclampsia Pregnancy Pregnancy complications Selenium Serum lipids Statistical analysis |
title | Selenium Deficiency is associated with inflammation and Cardio- metabolic dysregulation in women with Hypertensive disorders of Pregnancy |
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