Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd() complexes
A series of Pd( ii ) complexes of the general formula [PdX(NNS)] (X = Cl, Br, I, NCS and phenyl-tetrazole-thiolato; NNS = 2-quinolinecarboxyaldehyde- N 4 -phenylthiosemicarbazone) was tested against four malignant cell lines for their antiproliferative properties and the outcomes were compared to th...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2024-03, Vol.53 (11), p.573-583 |
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| creator | Mansour, Ahmed M Khaled, Rabaa M Radacki, Krzysztof Abo-Zeid, Mona A. M Shehab, Ola R Mostafa, Gamal A. E Ali, Essam A Abo-Elfadl, Mahmoud T |
| description | A series of Pd(
ii
) complexes of the general formula [PdX(NNS)] (X = Cl, Br, I, NCS and phenyl-tetrazole-thiolato; NNS = 2-quinolinecarboxyaldehyde-
N
4
-phenylthiosemicarbazone) was tested against four malignant cell lines for their antiproliferative properties and the outcomes were compared to those seen in normal mouse splenocytes. Various auxiliary ligands were substituted in order to investigate the impact of the character of the ligand on the cytotoxicity of this class of Pd(
ii
) complexes. The iodo complex was the most cytotoxic compound towards the Caco-2 cell line in this study. The improved apoptosis and necrosis cell modes were in accordance with the fragmentation results of DNA, which revealed increased fragmentation terminals, especially in isothiocyanate and tetrazole-thiolato complexes. After 24 hours, at half the IC
50
of each complex, the complex-treated cells exhibited considerable genotoxicity when compared to the corresponding non-treated control especially in the case of isothiocyanate and tetrazole-thiolato complexes.
We report how the cytotoxicity, mode of death and genotoxic effect of a series of square planar Pd(
ii
) complexes are determined by the auxiliary ligand coupled to the Pd(
ii
) ion, which is chelated by the tridentate thiosemicarbazone ligand. |
| doi_str_mv | 10.1039/d4dt00032c |
| format | Article |
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ii
) complexes of the general formula [PdX(NNS)] (X = Cl, Br, I, NCS and phenyl-tetrazole-thiolato; NNS = 2-quinolinecarboxyaldehyde-
N
4
-phenylthiosemicarbazone) was tested against four malignant cell lines for their antiproliferative properties and the outcomes were compared to those seen in normal mouse splenocytes. Various auxiliary ligands were substituted in order to investigate the impact of the character of the ligand on the cytotoxicity of this class of Pd(
ii
) complexes. The iodo complex was the most cytotoxic compound towards the Caco-2 cell line in this study. The improved apoptosis and necrosis cell modes were in accordance with the fragmentation results of DNA, which revealed increased fragmentation terminals, especially in isothiocyanate and tetrazole-thiolato complexes. After 24 hours, at half the IC
50
of each complex, the complex-treated cells exhibited considerable genotoxicity when compared to the corresponding non-treated control especially in the case of isothiocyanate and tetrazole-thiolato complexes.
We report how the cytotoxicity, mode of death and genotoxic effect of a series of square planar Pd(
ii
) complexes are determined by the auxiliary ligand coupled to the Pd(
ii
) ion, which is chelated by the tridentate thiosemicarbazone ligand.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/d4dt00032c</identifier><identifier>PMID: 38375910</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Apoptosis ; Cell death ; Fragmentation ; Genotoxicity ; Ligands ; Necrosis ; Tetrazoles</subject><ispartof>Dalton transactions : an international journal of inorganic chemistry, 2024-03, Vol.53 (11), p.573-583</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-4900b30d7d6b1a632aa2312d44ee85ffed1d6b407b43c42ea6dfb2dceab6c8543</cites><orcidid>0000-0002-5107-4304 ; 0000-0003-2095-5085 ; 0000-0002-0877-3636 ; 0000-0002-2415-0586 ; 0000-0003-1566-6684 ; 0000-0003-3088-6327</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38375910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mansour, Ahmed M</creatorcontrib><creatorcontrib>Khaled, Rabaa M</creatorcontrib><creatorcontrib>Radacki, Krzysztof</creatorcontrib><creatorcontrib>Abo-Zeid, Mona A. M</creatorcontrib><creatorcontrib>Shehab, Ola R</creatorcontrib><creatorcontrib>Mostafa, Gamal A. E</creatorcontrib><creatorcontrib>Ali, Essam A</creatorcontrib><creatorcontrib>Abo-Elfadl, Mahmoud T</creatorcontrib><title>Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd() complexes</title><title>Dalton transactions : an international journal of inorganic chemistry</title><addtitle>Dalton Trans</addtitle><description>A series of Pd(
ii
) complexes of the general formula [PdX(NNS)] (X = Cl, Br, I, NCS and phenyl-tetrazole-thiolato; NNS = 2-quinolinecarboxyaldehyde-
N
4
-phenylthiosemicarbazone) was tested against four malignant cell lines for their antiproliferative properties and the outcomes were compared to those seen in normal mouse splenocytes. Various auxiliary ligands were substituted in order to investigate the impact of the character of the ligand on the cytotoxicity of this class of Pd(
ii
) complexes. The iodo complex was the most cytotoxic compound towards the Caco-2 cell line in this study. The improved apoptosis and necrosis cell modes were in accordance with the fragmentation results of DNA, which revealed increased fragmentation terminals, especially in isothiocyanate and tetrazole-thiolato complexes. After 24 hours, at half the IC
50
of each complex, the complex-treated cells exhibited considerable genotoxicity when compared to the corresponding non-treated control especially in the case of isothiocyanate and tetrazole-thiolato complexes.
We report how the cytotoxicity, mode of death and genotoxic effect of a series of square planar Pd(
ii
) complexes are determined by the auxiliary ligand coupled to the Pd(
ii
) ion, which is chelated by the tridentate thiosemicarbazone ligand.</description><subject>Apoptosis</subject><subject>Cell death</subject><subject>Fragmentation</subject><subject>Genotoxicity</subject><subject>Ligands</subject><subject>Necrosis</subject><subject>Tetrazoles</subject><issn>1477-9226</issn><issn>1477-9234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpd0UtLAzEUBeAgiq3VjXsl4KYK1bzmtZTWFxQUqeshk9xpU2YmNZnB1l_v9GEFVwncj8PlHoTOKbmlhCd3WuiaEMKZOkBdKqJokDAuDvd_FnbQifdzQhgjATtGHR7zKEgo6aKvd1sAtjmuZ4BlszSFkW6FCzOVlcamwhpqcKWpTDXdmClUtrZLo0y9wmtTWr0JUFAUrZb1bBtnrIfSKOky-W0rwG-6f42VLRcFLMGfoqNcFh7Odm8PfTw-TIbPg_Hr08vwfjxQLAnrgUgIyTjRkQ4zKkPOpGScMi0EQBzkOWjaTgSJMsGVYCBDnWdMK5BZqOJA8B7qb3MXzn424Ou0NH69qqzANj5lCYvjgDMatPTqH53bxlXtdq0KAkYpidfqZquUs947yNOFM2V7s5SSdF1HOhKjyaaOYYsvd5FNVoLe09_7t-BiC5xX--lfn_wHDZ-P8Q</recordid><startdate>20240312</startdate><enddate>20240312</enddate><creator>Mansour, Ahmed M</creator><creator>Khaled, Rabaa M</creator><creator>Radacki, Krzysztof</creator><creator>Abo-Zeid, Mona A. M</creator><creator>Shehab, Ola R</creator><creator>Mostafa, Gamal A. E</creator><creator>Ali, Essam A</creator><creator>Abo-Elfadl, Mahmoud T</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5107-4304</orcidid><orcidid>https://orcid.org/0000-0003-2095-5085</orcidid><orcidid>https://orcid.org/0000-0002-0877-3636</orcidid><orcidid>https://orcid.org/0000-0002-2415-0586</orcidid><orcidid>https://orcid.org/0000-0003-1566-6684</orcidid><orcidid>https://orcid.org/0000-0003-3088-6327</orcidid></search><sort><creationdate>20240312</creationdate><title>Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd() complexes</title><author>Mansour, Ahmed M ; Khaled, Rabaa M ; Radacki, Krzysztof ; Abo-Zeid, Mona A. M ; Shehab, Ola R ; Mostafa, Gamal A. E ; Ali, Essam A ; Abo-Elfadl, Mahmoud T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-4900b30d7d6b1a632aa2312d44ee85ffed1d6b407b43c42ea6dfb2dceab6c8543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Apoptosis</topic><topic>Cell death</topic><topic>Fragmentation</topic><topic>Genotoxicity</topic><topic>Ligands</topic><topic>Necrosis</topic><topic>Tetrazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mansour, Ahmed M</creatorcontrib><creatorcontrib>Khaled, Rabaa M</creatorcontrib><creatorcontrib>Radacki, Krzysztof</creatorcontrib><creatorcontrib>Abo-Zeid, Mona A. M</creatorcontrib><creatorcontrib>Shehab, Ola R</creatorcontrib><creatorcontrib>Mostafa, Gamal A. E</creatorcontrib><creatorcontrib>Ali, Essam A</creatorcontrib><creatorcontrib>Abo-Elfadl, Mahmoud T</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mansour, Ahmed M</au><au>Khaled, Rabaa M</au><au>Radacki, Krzysztof</au><au>Abo-Zeid, Mona A. M</au><au>Shehab, Ola R</au><au>Mostafa, Gamal A. E</au><au>Ali, Essam A</au><au>Abo-Elfadl, Mahmoud T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd() complexes</atitle><jtitle>Dalton transactions : an international journal of inorganic chemistry</jtitle><addtitle>Dalton Trans</addtitle><date>2024-03-12</date><risdate>2024</risdate><volume>53</volume><issue>11</issue><spage>573</spage><epage>583</epage><pages>573-583</pages><issn>1477-9226</issn><eissn>1477-9234</eissn><abstract>A series of Pd(
ii
) complexes of the general formula [PdX(NNS)] (X = Cl, Br, I, NCS and phenyl-tetrazole-thiolato; NNS = 2-quinolinecarboxyaldehyde-
N
4
-phenylthiosemicarbazone) was tested against four malignant cell lines for their antiproliferative properties and the outcomes were compared to those seen in normal mouse splenocytes. Various auxiliary ligands were substituted in order to investigate the impact of the character of the ligand on the cytotoxicity of this class of Pd(
ii
) complexes. The iodo complex was the most cytotoxic compound towards the Caco-2 cell line in this study. The improved apoptosis and necrosis cell modes were in accordance with the fragmentation results of DNA, which revealed increased fragmentation terminals, especially in isothiocyanate and tetrazole-thiolato complexes. After 24 hours, at half the IC
50
of each complex, the complex-treated cells exhibited considerable genotoxicity when compared to the corresponding non-treated control especially in the case of isothiocyanate and tetrazole-thiolato complexes.
We report how the cytotoxicity, mode of death and genotoxic effect of a series of square planar Pd(
ii
) complexes are determined by the auxiliary ligand coupled to the Pd(
ii
) ion, which is chelated by the tridentate thiosemicarbazone ligand.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38375910</pmid><doi>10.1039/d4dt00032c</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5107-4304</orcidid><orcidid>https://orcid.org/0000-0003-2095-5085</orcidid><orcidid>https://orcid.org/0000-0002-0877-3636</orcidid><orcidid>https://orcid.org/0000-0002-2415-0586</orcidid><orcidid>https://orcid.org/0000-0003-1566-6684</orcidid><orcidid>https://orcid.org/0000-0003-3088-6327</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2024-03, Vol.53 (11), p.573-583 |
| issn | 1477-9226 1477-9234 |
| language | eng |
| recordid | cdi_proquest_journals_2955211085 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Apoptosis Cell death Fragmentation Genotoxicity Ligands Necrosis Tetrazoles |
| title | Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd() complexes |
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