Therapeutic Effects of Probiotics In The Reduction of Neonatal Hyperbilirubinemia
Objective: To evaluate probiotics' effects in reducing hyperbilirubinemia in late preterm and term neonates. Study Design: Quasi-experimental study Place and Duration of Study: Department of Neonatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad Pakistan, from Oct 2018 to Mar 201...
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| Veröffentlicht in: | Pakistan Armed Forces medical journal 2024-02, Vol.74 (1), p.113-116 |
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| creator | Ayesha Waheed Haider Shirazi Asma Mustafa Waheed, Yasir |
| description | Objective: To evaluate probiotics' effects in reducing hyperbilirubinemia in late preterm and term neonates.
Study Design: Quasi-experimental study
Place and Duration of Study: Department of Neonatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad Pakistan, from Oct 2018 to Mar 2019.
Methodology: The quasi-experimental study was conducted on 60 neonates with hyperbilirubinemia. They were randomlydivided into two Groups. Group-A (n=30) received phototherapy. Group-B (n=30) received probiotics containing Lactobacillus reuteri at a dose of 5 drops daily for three days, in addition to phototherapy. Total serum bilirubin was calculated at 0, 24 and 72 hours for both Groups.
Results: In Group-A, the mean total bilirubin in mg/dl at 0, 24 and 72 hours were 18.14±2.35, 15.28±2.93 and 12.31±2.29, respectively. Similarly, in Group-B, it was 19.86±5.85, 16.23±4.01 and 10.75±2.23 at 0, 24 and 72 hours, respectively. There was an insignificant statistical difference in mean total bilirubin between Groups A and B at 0 and 24 hours (p |
| doi_str_mv | 10.51253/pafmj.v74i1.3071 |
| format | Article |
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Study Design: Quasi-experimental study
Place and Duration of Study: Department of Neonatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad Pakistan, from Oct 2018 to Mar 2019.
Methodology: The quasi-experimental study was conducted on 60 neonates with hyperbilirubinemia. They were randomlydivided into two Groups. Group-A (n=30) received phototherapy. Group-B (n=30) received probiotics containing Lactobacillus reuteri at a dose of 5 drops daily for three days, in addition to phototherapy. Total serum bilirubin was calculated at 0, 24 and 72 hours for both Groups.
Results: In Group-A, the mean total bilirubin in mg/dl at 0, 24 and 72 hours were 18.14±2.35, 15.28±2.93 and 12.31±2.29, respectively. Similarly, in Group-B, it was 19.86±5.85, 16.23±4.01 and 10.75±2.23 at 0, 24 and 72 hours, respectively. There was an insignificant statistical difference in mean total bilirubin between Groups A and B at 0 and 24 hours (p<0.001). However, when comparison was made at 72 hours, a significant statistical difference was observed in Group-B (Intervention Group) (p=0.005)
Conclusion: Probiotics significantly lowered total serum bilirubin in neonates with hyperbilirubinemia. Further studies are required to evaluate its role in physiological and pathological jaundice.</description><identifier>ISSN: 0030-9648</identifier><identifier>EISSN: 2411-8842</identifier><identifier>DOI: 10.51253/pafmj.v74i1.3071</identifier><language>eng</language><publisher>Rawalpindi: Knowledge Bylanes</publisher><subject>Analysis ; Blood groups ; Data analysis ; Gestational age ; Health aspects ; Hospital costs ; Infants (Premature) ; Jaundice ; Light therapy ; Neonatal care ; Neonatal jaundice ; Neonatology ; Physiological aspects ; Physiology ; Probiotics ; Quasi-experimental methods ; Vagina</subject><ispartof>Pakistan Armed Forces medical journal, 2024-02, Vol.74 (1), p.113-116</ispartof><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><rights>(c)2024 Pakistan Armed Forces Medical Journal</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Ayesha Waheed</creatorcontrib><creatorcontrib>Haider Shirazi</creatorcontrib><creatorcontrib>Asma Mustafa</creatorcontrib><creatorcontrib>Waheed, Yasir</creatorcontrib><title>Therapeutic Effects of Probiotics In The Reduction of Neonatal Hyperbilirubinemia</title><title>Pakistan Armed Forces medical journal</title><description>Objective: To evaluate probiotics' effects in reducing hyperbilirubinemia in late preterm and term neonates.
Study Design: Quasi-experimental study
Place and Duration of Study: Department of Neonatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad Pakistan, from Oct 2018 to Mar 2019.
Methodology: The quasi-experimental study was conducted on 60 neonates with hyperbilirubinemia. They were randomlydivided into two Groups. Group-A (n=30) received phototherapy. Group-B (n=30) received probiotics containing Lactobacillus reuteri at a dose of 5 drops daily for three days, in addition to phototherapy. Total serum bilirubin was calculated at 0, 24 and 72 hours for both Groups.
Results: In Group-A, the mean total bilirubin in mg/dl at 0, 24 and 72 hours were 18.14±2.35, 15.28±2.93 and 12.31±2.29, respectively. Similarly, in Group-B, it was 19.86±5.85, 16.23±4.01 and 10.75±2.23 at 0, 24 and 72 hours, respectively. There was an insignificant statistical difference in mean total bilirubin between Groups A and B at 0 and 24 hours (p<0.001). However, when comparison was made at 72 hours, a significant statistical difference was observed in Group-B (Intervention Group) (p=0.005)
Conclusion: Probiotics significantly lowered total serum bilirubin in neonates with hyperbilirubinemia. Further studies are required to evaluate its role in physiological and pathological jaundice.</description><subject>Analysis</subject><subject>Blood groups</subject><subject>Data analysis</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Hospital costs</subject><subject>Infants (Premature)</subject><subject>Jaundice</subject><subject>Light therapy</subject><subject>Neonatal care</subject><subject>Neonatal jaundice</subject><subject>Neonatology</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Probiotics</subject><subject>Quasi-experimental methods</subject><subject>Vagina</subject><issn>0030-9648</issn><issn>2411-8842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUclqwzAQFaWFhjYf0JuhZ6daLfsYQtoEQjfSs5BkqVWwLVeyC_n7Kkkvgc4cZph5bxYeAHcIzhjCjDz00ra72Q-nDs0I5OgCTDBFKC9Lii_BBEIC86qg5TWYxriDyRjBFLIJeNt-mSB7Mw5OZ0trjR5i5m32GrxyPhVjtu6yBMreTT3qwfnu0H42vpODbLLVvjdBucaFUbnOtE7egisrm2imf_EGfDwut4tVvnl5Wi_mm1xjBlFeVQYZXHOFeA2hRAXW6ViuSs0sYVTXFFmOK2pNrYqUyLqQSjKFikKWFCJyA-5Pc_vgv0cTB7HzY-jSSpFoGFX8DPUpGyNcZ_0QpG5d1GLOS0bSXswTavYPKnmdPtK-M9al-hkBnQg6-BiDsaIPrpVhLxAUR03EURNx1EQcNCG_N45-2A</recordid><startdate>20240229</startdate><enddate>20240229</enddate><creator>Ayesha Waheed</creator><creator>Haider Shirazi</creator><creator>Asma Mustafa</creator><creator>Waheed, Yasir</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20240229</creationdate><title>Therapeutic Effects of Probiotics In The Reduction of Neonatal Hyperbilirubinemia</title><author>Ayesha Waheed ; Haider Shirazi ; Asma Mustafa ; Waheed, Yasir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2501-99e1e2d7b17d00a162c8427b8c5f354cd41f7294fedb6729ad6aba5b166a84013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Blood groups</topic><topic>Data analysis</topic><topic>Gestational age</topic><topic>Health aspects</topic><topic>Hospital costs</topic><topic>Infants (Premature)</topic><topic>Jaundice</topic><topic>Light therapy</topic><topic>Neonatal care</topic><topic>Neonatal jaundice</topic><topic>Neonatology</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Probiotics</topic><topic>Quasi-experimental methods</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayesha Waheed</creatorcontrib><creatorcontrib>Haider Shirazi</creatorcontrib><creatorcontrib>Asma Mustafa</creatorcontrib><creatorcontrib>Waheed, Yasir</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Pakistan Armed Forces medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayesha Waheed</au><au>Haider Shirazi</au><au>Asma Mustafa</au><au>Waheed, Yasir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic Effects of Probiotics In The Reduction of Neonatal Hyperbilirubinemia</atitle><jtitle>Pakistan Armed Forces medical journal</jtitle><date>2024-02-29</date><risdate>2024</risdate><volume>74</volume><issue>1</issue><spage>113</spage><epage>116</epage><pages>113-116</pages><issn>0030-9648</issn><eissn>2411-8842</eissn><abstract>Objective: To evaluate probiotics' effects in reducing hyperbilirubinemia in late preterm and term neonates.
Study Design: Quasi-experimental study
Place and Duration of Study: Department of Neonatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad Pakistan, from Oct 2018 to Mar 2019.
Methodology: The quasi-experimental study was conducted on 60 neonates with hyperbilirubinemia. They were randomlydivided into two Groups. Group-A (n=30) received phototherapy. Group-B (n=30) received probiotics containing Lactobacillus reuteri at a dose of 5 drops daily for three days, in addition to phototherapy. Total serum bilirubin was calculated at 0, 24 and 72 hours for both Groups.
Results: In Group-A, the mean total bilirubin in mg/dl at 0, 24 and 72 hours were 18.14±2.35, 15.28±2.93 and 12.31±2.29, respectively. Similarly, in Group-B, it was 19.86±5.85, 16.23±4.01 and 10.75±2.23 at 0, 24 and 72 hours, respectively. There was an insignificant statistical difference in mean total bilirubin between Groups A and B at 0 and 24 hours (p<0.001). However, when comparison was made at 72 hours, a significant statistical difference was observed in Group-B (Intervention Group) (p=0.005)
Conclusion: Probiotics significantly lowered total serum bilirubin in neonates with hyperbilirubinemia. Further studies are required to evaluate its role in physiological and pathological jaundice.</abstract><cop>Rawalpindi</cop><pub>Knowledge Bylanes</pub><doi>10.51253/pafmj.v74i1.3071</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Analysis Blood groups Data analysis Gestational age Health aspects Hospital costs Infants (Premature) Jaundice Light therapy Neonatal care Neonatal jaundice Neonatology Physiological aspects Physiology Probiotics Quasi-experimental methods Vagina |
| title | Therapeutic Effects of Probiotics In The Reduction of Neonatal Hyperbilirubinemia |
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